node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
aadK | fosB | BSU26790 | BSU17840 | Aminoglycoside 6-adenylyltransferase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; To E.faecalis AadE. | Metallothiol transferase; Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor. | 0.428 |
aadK | penP | BSU26790 | BSU18800 | Aminoglycoside 6-adenylyltransferase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; To E.faecalis AadE. | Beta-lactamase precursor; This protein is a beta-lactamase with a substrate specificity for penicillins. | 0.567 |
aadK | ycbJ | BSU26790 | BSU02520 | Aminoglycoside 6-adenylyltransferase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; To E.faecalis AadE. | Putative phosphotransferase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the aminoglycoside phosphotransferase family. | 0.483 |
aadK | yyaR | BSU26790 | BSU40740 | Aminoglycoside 6-adenylyltransferase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; To E.faecalis AadE. | Putative acetyl-transferase; Involved in resistance to streptothricin, a broad-spectrum antibiotic produced by streptomycetes. Detoxifies streptothricin via acetylation of the beta amino group of the first beta-lysyl moiety of streptothricin; Belongs to the acetyltransferase family. GNAT subfamily. | 0.831 |
fosB | aadK | BSU17840 | BSU26790 | Metallothiol transferase; Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor. | Aminoglycoside 6-adenylyltransferase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; To E.faecalis AadE. | 0.428 |
fosB | pksJ | BSU17840 | BSU17180 | Metallothiol transferase; Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor. | Polyketide synthase of type I; Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism. | 0.408 |
fosB | pksN | BSU17840 | BSU17210 | Metallothiol transferase; Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor. | Polyketide synthase of type I; Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism. | 0.430 |
fosB | ycbJ | BSU17840 | BSU02520 | Metallothiol transferase; Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor. | Putative phosphotransferase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the aminoglycoside phosphotransferase family. | 0.422 |
fosB | yyaR | BSU17840 | BSU40740 | Metallothiol transferase; Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor. | Putative acetyl-transferase; Involved in resistance to streptothricin, a broad-spectrum antibiotic produced by streptomycetes. Detoxifies streptothricin via acetylation of the beta amino group of the first beta-lysyl moiety of streptothricin; Belongs to the acetyltransferase family. GNAT subfamily. | 0.662 |
garD | ycbJ | BSU02510 | BSU02520 | D-galactarate dehydratase; Catalyzes the dehydration of galactarate to form 5-dehydro-4- deoxy-D-glucarate. | Putative phosphotransferase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the aminoglycoside phosphotransferase family. | 0.416 |
penP | aadK | BSU18800 | BSU26790 | Beta-lactamase precursor; This protein is a beta-lactamase with a substrate specificity for penicillins. | Aminoglycoside 6-adenylyltransferase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; To E.faecalis AadE. | 0.567 |
penP | ycbJ | BSU18800 | BSU02520 | Beta-lactamase precursor; This protein is a beta-lactamase with a substrate specificity for penicillins. | Putative phosphotransferase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the aminoglycoside phosphotransferase family. | 0.410 |
pksJ | fosB | BSU17180 | BSU17840 | Polyketide synthase of type I; Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism. | Metallothiol transferase; Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor. | 0.408 |
pksJ | pksN | BSU17180 | BSU17210 | Polyketide synthase of type I; Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism. | Polyketide synthase of type I; Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism. | 0.999 |
pksJ | ycbJ | BSU17180 | BSU02520 | Polyketide synthase of type I; Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism. | Putative phosphotransferase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the aminoglycoside phosphotransferase family. | 0.508 |
pksN | fosB | BSU17210 | BSU17840 | Polyketide synthase of type I; Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism. | Metallothiol transferase; Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor. | 0.430 |
pksN | pksJ | BSU17210 | BSU17180 | Polyketide synthase of type I; Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism. | Polyketide synthase of type I; Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism. | 0.999 |
pksN | ycbJ | BSU17210 | BSU02520 | Polyketide synthase of type I; Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism. | Putative phosphotransferase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the aminoglycoside phosphotransferase family. | 0.465 |
ycbJ | aadK | BSU02520 | BSU26790 | Putative phosphotransferase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the aminoglycoside phosphotransferase family. | Aminoglycoside 6-adenylyltransferase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; To E.faecalis AadE. | 0.483 |
ycbJ | fosB | BSU02520 | BSU17840 | Putative phosphotransferase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the aminoglycoside phosphotransferase family. | Metallothiol transferase; Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor. | 0.422 |