| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| mtrB | pabA | BSU22770 | BSU00750 | Tryptophan operon RNA-binding attenuation protein (TRAP); Required for transcription attenuation control in the trp operon. This trans-acting factor binds to trinucleotide repeats (GAG or UAG) located in the trp leader transcript causing transcription termination. Binds the leader RNA only in presence of L-tryptophan. Belongs to the MtrB family. | 4-amino-4-deoxychorismate synthase; Part of a heterodimeric complex that catalyzes the two-step biosynthesis of 4-amino-4-deoxychorismate (ADC), a precursor of p- aminobenzoate (PABA) and tetrahydrofolate. In the first step, a glutamine amidotransferase (PabA) generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by aminodeoxychorismate synthase (PabB) to produce ADC. PabA converts glutamine into glutamate only in the presence of stoichiometric amounts of PabB. Also involved in the biosynthesis of anthranilate. | 0.919 |
| mtrB | rtpA | BSU22770 | BSU02530 | Tryptophan operon RNA-binding attenuation protein (TRAP); Required for transcription attenuation control in the trp operon. This trans-acting factor binds to trinucleotide repeats (GAG or UAG) located in the trp leader transcript causing transcription termination. Binds the leader RNA only in presence of L-tryptophan. Belongs to the MtrB family. | anti-TRAP regulator; By forming a complex with tryptophan-activated TRAP, and masking its RNA binding site, it inhibits TRAP's RNA binding ability, thereby abolishing TRAP regulation of gene expression, leading to antitermination and increased trp operon expression. AT acts by competing with messenger RNA for the RNA binding domain of TRAP. | 0.986 |
| mtrB | trpP | BSU22770 | BSU10010 | Tryptophan operon RNA-binding attenuation protein (TRAP); Required for transcription attenuation control in the trp operon. This trans-acting factor binds to trinucleotide repeats (GAG or UAG) located in the trp leader transcript causing transcription termination. Binds the leader RNA only in presence of L-tryptophan. Belongs to the MtrB family. | Tryptophan transporter; Probably involved in tryptophan uptake; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. TrpP subfamily. | 0.909 |
| mtrB | ycbK | BSU22770 | BSU02540 | Tryptophan operon RNA-binding attenuation protein (TRAP); Required for transcription attenuation control in the trp operon. This trans-acting factor binds to trinucleotide repeats (GAG or UAG) located in the trp leader transcript causing transcription termination. Binds the leader RNA only in presence of L-tryptophan. Belongs to the MtrB family. | Putative efflux transporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. | 0.888 |
| pabA | mtrB | BSU00750 | BSU22770 | 4-amino-4-deoxychorismate synthase; Part of a heterodimeric complex that catalyzes the two-step biosynthesis of 4-amino-4-deoxychorismate (ADC), a precursor of p- aminobenzoate (PABA) and tetrahydrofolate. In the first step, a glutamine amidotransferase (PabA) generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by aminodeoxychorismate synthase (PabB) to produce ADC. PabA converts glutamine into glutamate only in the presence of stoichiometric amounts of PabB. Also involved in the biosynthesis of anthranilate. | Tryptophan operon RNA-binding attenuation protein (TRAP); Required for transcription attenuation control in the trp operon. This trans-acting factor binds to trinucleotide repeats (GAG or UAG) located in the trp leader transcript causing transcription termination. Binds the leader RNA only in presence of L-tryptophan. Belongs to the MtrB family. | 0.919 |
| pabA | rtpA | BSU00750 | BSU02530 | 4-amino-4-deoxychorismate synthase; Part of a heterodimeric complex that catalyzes the two-step biosynthesis of 4-amino-4-deoxychorismate (ADC), a precursor of p- aminobenzoate (PABA) and tetrahydrofolate. In the first step, a glutamine amidotransferase (PabA) generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by aminodeoxychorismate synthase (PabB) to produce ADC. PabA converts glutamine into glutamate only in the presence of stoichiometric amounts of PabB. Also involved in the biosynthesis of anthranilate. | anti-TRAP regulator; By forming a complex with tryptophan-activated TRAP, and masking its RNA binding site, it inhibits TRAP's RNA binding ability, thereby abolishing TRAP regulation of gene expression, leading to antitermination and increased trp operon expression. AT acts by competing with messenger RNA for the RNA binding domain of TRAP. | 0.483 |
| pabA | trpP | BSU00750 | BSU10010 | 4-amino-4-deoxychorismate synthase; Part of a heterodimeric complex that catalyzes the two-step biosynthesis of 4-amino-4-deoxychorismate (ADC), a precursor of p- aminobenzoate (PABA) and tetrahydrofolate. In the first step, a glutamine amidotransferase (PabA) generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by aminodeoxychorismate synthase (PabB) to produce ADC. PabA converts glutamine into glutamate only in the presence of stoichiometric amounts of PabB. Also involved in the biosynthesis of anthranilate. | Tryptophan transporter; Probably involved in tryptophan uptake; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. TrpP subfamily. | 0.936 |
| pabA | ycbK | BSU00750 | BSU02540 | 4-amino-4-deoxychorismate synthase; Part of a heterodimeric complex that catalyzes the two-step biosynthesis of 4-amino-4-deoxychorismate (ADC), a precursor of p- aminobenzoate (PABA) and tetrahydrofolate. In the first step, a glutamine amidotransferase (PabA) generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by aminodeoxychorismate synthase (PabB) to produce ADC. PabA converts glutamine into glutamate only in the presence of stoichiometric amounts of PabB. Also involved in the biosynthesis of anthranilate. | Putative efflux transporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. | 0.852 |
| rtpA | mtrB | BSU02530 | BSU22770 | anti-TRAP regulator; By forming a complex with tryptophan-activated TRAP, and masking its RNA binding site, it inhibits TRAP's RNA binding ability, thereby abolishing TRAP regulation of gene expression, leading to antitermination and increased trp operon expression. AT acts by competing with messenger RNA for the RNA binding domain of TRAP. | Tryptophan operon RNA-binding attenuation protein (TRAP); Required for transcription attenuation control in the trp operon. This trans-acting factor binds to trinucleotide repeats (GAG or UAG) located in the trp leader transcript causing transcription termination. Binds the leader RNA only in presence of L-tryptophan. Belongs to the MtrB family. | 0.986 |
| rtpA | pabA | BSU02530 | BSU00750 | anti-TRAP regulator; By forming a complex with tryptophan-activated TRAP, and masking its RNA binding site, it inhibits TRAP's RNA binding ability, thereby abolishing TRAP regulation of gene expression, leading to antitermination and increased trp operon expression. AT acts by competing with messenger RNA for the RNA binding domain of TRAP. | 4-amino-4-deoxychorismate synthase; Part of a heterodimeric complex that catalyzes the two-step biosynthesis of 4-amino-4-deoxychorismate (ADC), a precursor of p- aminobenzoate (PABA) and tetrahydrofolate. In the first step, a glutamine amidotransferase (PabA) generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by aminodeoxychorismate synthase (PabB) to produce ADC. PabA converts glutamine into glutamate only in the presence of stoichiometric amounts of PabB. Also involved in the biosynthesis of anthranilate. | 0.483 |
| rtpA | ycbK | BSU02530 | BSU02540 | anti-TRAP regulator; By forming a complex with tryptophan-activated TRAP, and masking its RNA binding site, it inhibits TRAP's RNA binding ability, thereby abolishing TRAP regulation of gene expression, leading to antitermination and increased trp operon expression. AT acts by competing with messenger RNA for the RNA binding domain of TRAP. | Putative efflux transporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. | 0.972 |
| rtpA | ycbL | BSU02530 | BSU02550 | anti-TRAP regulator; By forming a complex with tryptophan-activated TRAP, and masking its RNA binding site, it inhibits TRAP's RNA binding ability, thereby abolishing TRAP regulation of gene expression, leading to antitermination and increased trp operon expression. AT acts by competing with messenger RNA for the RNA binding domain of TRAP. | Two-component response regulator [YcbM]; Member of the two-component regulatory system YcbM/YcbL. | 0.519 |
| trpP | mtrB | BSU10010 | BSU22770 | Tryptophan transporter; Probably involved in tryptophan uptake; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. TrpP subfamily. | Tryptophan operon RNA-binding attenuation protein (TRAP); Required for transcription attenuation control in the trp operon. This trans-acting factor binds to trinucleotide repeats (GAG or UAG) located in the trp leader transcript causing transcription termination. Binds the leader RNA only in presence of L-tryptophan. Belongs to the MtrB family. | 0.909 |
| trpP | pabA | BSU10010 | BSU00750 | Tryptophan transporter; Probably involved in tryptophan uptake; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. TrpP subfamily. | 4-amino-4-deoxychorismate synthase; Part of a heterodimeric complex that catalyzes the two-step biosynthesis of 4-amino-4-deoxychorismate (ADC), a precursor of p- aminobenzoate (PABA) and tetrahydrofolate. In the first step, a glutamine amidotransferase (PabA) generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by aminodeoxychorismate synthase (PabB) to produce ADC. PabA converts glutamine into glutamate only in the presence of stoichiometric amounts of PabB. Also involved in the biosynthesis of anthranilate. | 0.936 |
| trpP | ycbK | BSU10010 | BSU02540 | Tryptophan transporter; Probably involved in tryptophan uptake; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. TrpP subfamily. | Putative efflux transporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. | 0.919 |
| ybfF | ybfG | BSU02190 | BSU02200 | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. | Putative pepdidoglycan binding protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf: putative factor. | 0.893 |
| ybfF | ycbK | BSU02190 | BSU02540 | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. | Putative efflux transporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. | 0.677 |
| ybfF | ycbL | BSU02190 | BSU02550 | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. | Two-component response regulator [YcbM]; Member of the two-component regulatory system YcbM/YcbL. | 0.687 |
| ybfF | ydbI | BSU02190 | BSU04480 | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. | Putative integral inner membrane protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm: putative membrane component. | 0.688 |
| ybfF | ydbJ | BSU02190 | BSU04490 | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. | Putative ABC transporter (ATP-binding protein); Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter; Belongs to the ABC transporter superfamily. | 0.688 |