node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
blt | lmrA | BSU26590 | BSU02680 | Efflux transporter; Energy-dependent efflux pump responsible for decreased drug accumulation in multi-drug-resistant cells. Probably uses a transmembrane proton gradient as the energy source. Causes the efflux of a variety of toxic substances, including such structurally diverse compounds as ethidium bromide, rhodamine and acridine dyes, tetraphenylphosphonium, puromycin, chloramphenicol, doxorubicin, and fluoroquinolone antibiotics; Belongs to the major facilitator superfamily. TCR/Tet family. | Transcriptional repressor of lmrAB and yxaGH operons; Acts as repressor of the lincomycin-resistance (lmrAB) and yxaGH operons. | 0.423 |
blt | lmrB | BSU26590 | BSU02670 | Efflux transporter; Energy-dependent efflux pump responsible for decreased drug accumulation in multi-drug-resistant cells. Probably uses a transmembrane proton gradient as the energy source. Causes the efflux of a variety of toxic substances, including such structurally diverse compounds as ethidium bromide, rhodamine and acridine dyes, tetraphenylphosphonium, puromycin, chloramphenicol, doxorubicin, and fluoroquinolone antibiotics; Belongs to the major facilitator superfamily. TCR/Tet family. | Efflux transporter; Proton-dependent transporter. May mediate the efflux of lincomycin; Belongs to the major facilitator superfamily. EmrB family. | 0.751 |
bmr | lmrB | BSU24010 | BSU02670 | Multidrug-efflux transporter; Energy-dependent efflux pump responsible for decreased drug accumulation in multi-drug-resistant cells. Probably uses a transmembrane proton gradient as the energy source. Causes the efflux of a variety of toxic substances, including such structurally diverse compounds as ethidium bromide, rhodamine and acridine dyes, tetraphenylphosphonium, puromycin, chloramphenicol, doxorubicin, and fluoroquinolone antibiotics; Belongs to the major facilitator superfamily. TCR/Tet family. | Efflux transporter; Proton-dependent transporter. May mediate the efflux of lincomycin; Belongs to the major facilitator superfamily. EmrB family. | 0.891 |
bmr | vmlR | BSU24010 | BSU05610 | Multidrug-efflux transporter; Energy-dependent efflux pump responsible for decreased drug accumulation in multi-drug-resistant cells. Probably uses a transmembrane proton gradient as the energy source. Causes the efflux of a variety of toxic substances, including such structurally diverse compounds as ethidium bromide, rhodamine and acridine dyes, tetraphenylphosphonium, puromycin, chloramphenicol, doxorubicin, and fluoroquinolone antibiotics; Belongs to the major facilitator superfamily. TCR/Tet family. | ATP-binding cassette efflux transporter; Recognizes and binds in the vacant E-site of ribosomes stalled by some peptidyltransferase center (PTC)-targeting antibiotics. Makes contact with the PTC and both ribosomal subunits. Induces conformational changes in the P-site, which allows it to dislodge the antibiotic from its PTC binding site. Binds to ribosomes either directly following translation initation or subsequent to E tRNA release during elongation. Involved in resistance to a narrow spectrum of antibiotics (the streptogramin A antibiotic virginiamycin M, the lincosamide antibiotic [...] | 0.687 |
lmrA | blt | BSU02680 | BSU26590 | Transcriptional repressor of lmrAB and yxaGH operons; Acts as repressor of the lincomycin-resistance (lmrAB) and yxaGH operons. | Efflux transporter; Energy-dependent efflux pump responsible for decreased drug accumulation in multi-drug-resistant cells. Probably uses a transmembrane proton gradient as the energy source. Causes the efflux of a variety of toxic substances, including such structurally diverse compounds as ethidium bromide, rhodamine and acridine dyes, tetraphenylphosphonium, puromycin, chloramphenicol, doxorubicin, and fluoroquinolone antibiotics; Belongs to the major facilitator superfamily. TCR/Tet family. | 0.423 |
lmrA | lmrB | BSU02680 | BSU02670 | Transcriptional repressor of lmrAB and yxaGH operons; Acts as repressor of the lincomycin-resistance (lmrAB) and yxaGH operons. | Efflux transporter; Proton-dependent transporter. May mediate the efflux of lincomycin; Belongs to the major facilitator superfamily. EmrB family. | 0.991 |
lmrA | yccK | BSU02680 | BSU02770 | Transcriptional repressor of lmrAB and yxaGH operons; Acts as repressor of the lincomycin-resistance (lmrAB) and yxaGH operons. | Putative ion channel associated enzyme; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily. | 0.487 |
lmrB | blt | BSU02670 | BSU26590 | Efflux transporter; Proton-dependent transporter. May mediate the efflux of lincomycin; Belongs to the major facilitator superfamily. EmrB family. | Efflux transporter; Energy-dependent efflux pump responsible for decreased drug accumulation in multi-drug-resistant cells. Probably uses a transmembrane proton gradient as the energy source. Causes the efflux of a variety of toxic substances, including such structurally diverse compounds as ethidium bromide, rhodamine and acridine dyes, tetraphenylphosphonium, puromycin, chloramphenicol, doxorubicin, and fluoroquinolone antibiotics; Belongs to the major facilitator superfamily. TCR/Tet family. | 0.751 |
lmrB | bmr | BSU02670 | BSU24010 | Efflux transporter; Proton-dependent transporter. May mediate the efflux of lincomycin; Belongs to the major facilitator superfamily. EmrB family. | Multidrug-efflux transporter; Energy-dependent efflux pump responsible for decreased drug accumulation in multi-drug-resistant cells. Probably uses a transmembrane proton gradient as the energy source. Causes the efflux of a variety of toxic substances, including such structurally diverse compounds as ethidium bromide, rhodamine and acridine dyes, tetraphenylphosphonium, puromycin, chloramphenicol, doxorubicin, and fluoroquinolone antibiotics; Belongs to the major facilitator superfamily. TCR/Tet family. | 0.891 |
lmrB | lmrA | BSU02670 | BSU02680 | Efflux transporter; Proton-dependent transporter. May mediate the efflux of lincomycin; Belongs to the major facilitator superfamily. EmrB family. | Transcriptional repressor of lmrAB and yxaGH operons; Acts as repressor of the lincomycin-resistance (lmrAB) and yxaGH operons. | 0.991 |
lmrB | qdoR | BSU02670 | BSU39990 | Efflux transporter; Proton-dependent transporter. May mediate the efflux of lincomycin; Belongs to the major facilitator superfamily. EmrB family. | Transcriptional regulator; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type r: regulator. | 0.595 |
lmrB | vmlR | BSU02670 | BSU05610 | Efflux transporter; Proton-dependent transporter. May mediate the efflux of lincomycin; Belongs to the major facilitator superfamily. EmrB family. | ATP-binding cassette efflux transporter; Recognizes and binds in the vacant E-site of ribosomes stalled by some peptidyltransferase center (PTC)-targeting antibiotics. Makes contact with the PTC and both ribosomal subunits. Induces conformational changes in the P-site, which allows it to dislodge the antibiotic from its PTC binding site. Binds to ribosomes either directly following translation initation or subsequent to E tRNA release during elongation. Involved in resistance to a narrow spectrum of antibiotics (the streptogramin A antibiotic virginiamycin M, the lincosamide antibiotic [...] | 0.684 |
lmrB | ycbU | BSU02670 | BSU02660 | Efflux transporter; Proton-dependent transporter. May mediate the efflux of lincomycin; Belongs to the major facilitator superfamily. EmrB family. | Putative cysteine desulfurase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. | 0.569 |
lmrB | yccK | BSU02670 | BSU02770 | Efflux transporter; Proton-dependent transporter. May mediate the efflux of lincomycin; Belongs to the major facilitator superfamily. EmrB family. | Putative ion channel associated enzyme; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily. | 0.634 |
lmrB | ycgQ | BSU02670 | BSU03240 | Efflux transporter; Proton-dependent transporter. May mediate the efflux of lincomycin; Belongs to the major facilitator superfamily. EmrB family. | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. | 0.712 |
lmrB | yddI | BSU02670 | BSU04980 | Efflux transporter; Proton-dependent transporter. May mediate the efflux of lincomycin; Belongs to the major facilitator superfamily. EmrB family. | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. | 0.607 |
lmrB | ywfA | BSU02670 | BSU37750 | Efflux transporter; Proton-dependent transporter. May mediate the efflux of lincomycin; Belongs to the major facilitator superfamily. EmrB family. | Putative efflux transporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. | 0.671 |
qdoR | lmrB | BSU39990 | BSU02670 | Transcriptional regulator; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type r: regulator. | Efflux transporter; Proton-dependent transporter. May mediate the efflux of lincomycin; Belongs to the major facilitator superfamily. EmrB family. | 0.595 |
vmlR | bmr | BSU05610 | BSU24010 | ATP-binding cassette efflux transporter; Recognizes and binds in the vacant E-site of ribosomes stalled by some peptidyltransferase center (PTC)-targeting antibiotics. Makes contact with the PTC and both ribosomal subunits. Induces conformational changes in the P-site, which allows it to dislodge the antibiotic from its PTC binding site. Binds to ribosomes either directly following translation initation or subsequent to E tRNA release during elongation. Involved in resistance to a narrow spectrum of antibiotics (the streptogramin A antibiotic virginiamycin M, the lincosamide antibiotic [...] | Multidrug-efflux transporter; Energy-dependent efflux pump responsible for decreased drug accumulation in multi-drug-resistant cells. Probably uses a transmembrane proton gradient as the energy source. Causes the efflux of a variety of toxic substances, including such structurally diverse compounds as ethidium bromide, rhodamine and acridine dyes, tetraphenylphosphonium, puromycin, chloramphenicol, doxorubicin, and fluoroquinolone antibiotics; Belongs to the major facilitator superfamily. TCR/Tet family. | 0.687 |
vmlR | lmrB | BSU05610 | BSU02670 | ATP-binding cassette efflux transporter; Recognizes and binds in the vacant E-site of ribosomes stalled by some peptidyltransferase center (PTC)-targeting antibiotics. Makes contact with the PTC and both ribosomal subunits. Induces conformational changes in the P-site, which allows it to dislodge the antibiotic from its PTC binding site. Binds to ribosomes either directly following translation initation or subsequent to E tRNA release during elongation. Involved in resistance to a narrow spectrum of antibiotics (the streptogramin A antibiotic virginiamycin M, the lincosamide antibiotic [...] | Efflux transporter; Proton-dependent transporter. May mediate the efflux of lincomycin; Belongs to the major facilitator superfamily. EmrB family. | 0.684 |