STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
natRTwo-component response regulator [NatK]; Member of the two-component regulatory system NatK/NatR that positively regulates the expression of the natAB operon. Acts by binding directly to the promoter of natAB. (233 aa)    
Predicted Functional Partners:
natK
Two-component sensor histidine kinase [NatR]; Member of the two-component regulatory system NatK/NatR that positively regulates the expression of the natAB operon. Potentially phosphorylates NatR.
 
 
 0.999
lytS
Two-component sensor histidine kinase [LytT]; Member of the two-component regulatory system LytS/LytT that probably regulates genes involved in cell wall metabolism.
 
 
 0.920
yclK
Two-component sensor histidine kinase [YclJ]; Could be member of the two-component regulatory system YclK/YclJ. Potentially phosphorylates YclJ.
  
  
 0.855
ywpD
Putative two-component sensor histidine kinase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative receptor.
 
  
 0.854
yesM
Two-component sensor histidine kinase [YesN]; Member of the two-component regulatory system YesM/YesN. Probably activates YesN by phosphorylation.
 
  
 0.843
yclJ
Two-component response regulator [YclK]; Could be member of the two-component regulatory system YclK/YclJ.
   
  
 0.772
natA
Na+ ABC efflux transporter (ATP-binding protein); Part of an ABC transporter that catalyzes ATP-dependent electrogenic sodium extrusion; Belongs to the ABC transporter superfamily.
 
    0.630
natB
Na+ ABC efflux transporter (permease); Part of an ABC transporter that catalyzes ATP-dependent electrogenic sodium extrusion.
  
    0.579
lrgA
Antiholin factor; Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses; Belongs to the CidA/LrgA family. LrgA subfamily.
 
   
 0.494
cheV
Coupling protein and response regulator for CheA activity in response to attractants (chemotaxis); Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. Chemotaxis involves both a phosphorylation-dependent excitation and a methylation-dependent adaptation. CheV and CheW are involved in the coupling of the methyl- accepting chemoreceptors to the central two-component kinase CheA; they are both necessary for efficient chemotaxis. Moreover, CheA-dependent phosphorylation of CheV is required for adaptation to attractants during B.subtilis chemotaxis.
 
   
 0.413
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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