STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
znuBHigh affinity zn(ii) abc transporter (permease); Part of the high-affinity ABC transporter complex ZnuABC involved in zinc import (Probable). Responsible for the translocation of the substrate across the membrane (By similarity). ZnuABC-mediated zinc transport is required for comF expression and competence development (280 aa)    
Predicted Functional Partners:
znuA
Zinc transport system zinc-binding lipoprotein adca; Part of the high-affinity ABC transporter complex ZnuABC involved in zinc import (Probable). ZnuABC-mediated zinc transport is required for comF expression and competence development
 
 0.999
znuC
Zinc transport system atp-binding protein adcc; Part of the high-affinity ABC transporter complex ZnuABC involved in zinc import (Probable). Responsible for energy coupling to the transport system (By similarity). ZnuABC-mediated zinc transport is required for comF expression and competence development
 0.999
yrpE
Zinc transport system substrate-binding protein; Belongs to the calycin superfamily. ZinT family
 
 
 0.972
zinT
Zinc metallochaperone with ntpase activity; May bind GTP. Might act as metal chaperone (Potential). Contributes to optimal growth under starvation for zinc
     
 0.945
zosA
Zn2+/Cd2+-exporting ATPase; Couples the hydrolysis of ATP with the transport of zinc into the cell. Plays an important role in protecting cells against oxidative stress. ZosA-mediated zinc transport is required for post- transcriptional control of comK and competence development
   
  
 0.894
yciB
Putative metal uptake system lipoprotein; Putative L,D-transpeptidase YciB; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter
     
 0.880
mntB
Manganese/zinc/iron transport system atp- binding protein; Probably part of the ABC transporter complex MntABCD involved in manganese import. Probably responsible for energy coupling to the transport system
 
 0.873
mntD
Manganese/zinc/iron transport system permease protein; Probably part of the ABC transporter complex MntABCD involved in manganese import. Probably responsible for the translocation of the substrate across the membrane
 
  
 0.857
folEB
Gtp cyclohydrolase fole2; Converts GTP to 7,8-dihydroneopterin triphosphate
     
 0.794
zur
Fur family transcriptional regulator, zinc uptake regulator; Acts as a negative controlling element, employing Zn(2+) as a cofactor to bind the operator of the repressed genes. Required for the zinc-specific repression of two operons implicated in zinc uptake, yciC and ycdHIyceA. Also represses the expression of rpmE2, the gene for ribosomal protein L31B, which is expressed only after the end of exponential growth
    
 0.781
Your Current Organism:
Bacillus subtilis
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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