Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
znuBHigh affinity Zn(II) ABC transporter (permease); Part of the high-affinity ABC transporter complex ZnuABC involved in zinc import (Probable). Responsible for the translocation of the substrate across the membrane (By similarity). ZnuABC-mediated zinc transport is required for comF expression and competence development. (280 aa)    
Predicted Functional Partners:
znuA
Zn(II)-binding lipoprotein; Part of the high-affinity ABC transporter complex ZnuABC involved in zinc import (Probable). ZnuABC-mediated zinc transport is required for comF expression and competence development.
 
 
 0.999
znuC
Zn(II) transporter (ATP-binding protein); Part of the high-affinity ABC transporter complex ZnuABC involved in zinc import (Probable). Responsible for energy coupling to the transport system (By similarity). ZnuABC-mediated zinc transport is required for comF expression and competence development.
 0.999
mntB
Manganese ABC transporter (ATP-binding protein); Probably part of the ABC transporter complex MntABCD involved in manganese import. Probably responsible for energy coupling to the transport system.
 0.974
yrpE
Putative lipoprotein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp: lipoprotein; Belongs to the calycin superfamily. ZinT family.
  
 
 0.971
zinT
Zinc metallochaperone with NTPase activity; May bind GTP. Might act as metal chaperone (Potential). Contributes to optimal growth under starvation for zinc.
  
  
 0.935
mntA
Manganese ABC transporter (manganese binding lipoprotein); Probably part of the ABC transporter complex MntABCD involved in manganese import.
 
  
 0.875
mntD
Manganese ABC transporter (permease); Probably part of the ABC transporter complex MntABCD involved in manganese import. Probably responsible for the translocation of the substrate across the membrane; Belongs to the ABC-3 integral membrane protein family.
  
  
  0.844
zosA
Zn transporter; Couples the hydrolysis of ATP with the transport of zinc into the cell. Plays an important role in protecting cells against oxidative stress. ZosA-mediated zinc transport is required for post- transcriptional control of comK and competence development.
  
  
 0.806
yciB
Putative metal uptake system lipoprotein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter.
  
  
 0.783
zur
Transcriptional regulator (Fur family); Acts as a negative controlling element, employing Zn(2+) as a cofactor to bind the operator of the repressed genes. Required for the zinc-specific repression of two operons implicated in zinc uptake, yciC and ycdHIyceA. Also represses the expression of rpmE2, the gene for ribosomal protein L31B, which is expressed only after the end of exponential growth.
  
  
 0.730
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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