STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nucAEndonuclease; By degrading DNA that enters the cell, plays a role in the competence of cells to be transformed. Degrades both double-stranded, linear and covalently closed circular DNA. (147 aa)    
Predicted Functional Partners:
nin
Inhibitor of the DNA degrading activity of NucA (competence); Plays a role in the competence of cells to be transformed. It inhibits the activity of the DNA-entry nuclease.
  
  
 0.989
comFA
Helicase competence protein; Involved in transformation (competence for DNA uptake). Required for DNA uptake but not for binding. May provide the driving force for transport of DNA through an aqueous channel. Belongs to the helicase family.
   
  
 0.953
comEA
Membrane bound high-affinity DNA-binding receptor; Needed for both DNA binding and transport. It is absolutely required for the uptake of transforming DNA but not for binding. Its role in binding may be indirect.
  
  
 0.899
ssbB
Single-strand DNA-binding protein; Not essential for replication of the chromosome, but is required for optimal competence. Binds ssDNA, binding is facilitated by DprA, acts as an accessory factor for homologous DNA strand exchange.
   
  
 0.892
comEC
DNA channel for uptake in competent cells; The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding; To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI.
  
  
 0.889
comK
Competence transcription factor (CTF); A master regulator required for the expression of late competence genes including comC, comE, comG and the bdbDC operon. Receives signals from SrfA, and possibly other regulatory COM genes, and transduces these signals to the late COM genes. Represses transcription of rok. May repress expression of a few genes.
   
  
 0.884
comC
Membrane protease and transmethylase; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue; Belongs to the peptidase A24 family.
   
  
 0.873
comFB
Conserved hypothetical protein; Evidence 1a: Function experimentally demonstrated in the studied strain; PubMedId: 16009133, 8045879, 8412657.
   
  
 0.864
comFC
Putative component of the DNA transport apparatus; Involved in transformation (competence for DNA uptake).
   
  
 0.811
comGE
Component of the DNA transport platform; Required for transformation and DNA binding.
   
  
 0.798
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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