STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yclJTwo-component system, ompr family, response regulator; Could be member of the two-component regulatory system YclK/YclJ (227 aa)    
Predicted Functional Partners:
yclK
Two-component sensor histidine kinase [yclj]; Could be member of the two-component regulatory system YclK/YclJ. Potentially phosphorylates YclJ
 
 0.998
cheA
Two-component system, chemotaxis family, sensor kinase chea; Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheA is autophosphorylated; it can transfer its phosphate group to CheB, CheY or CheV
  
 
 0.997
yfjR
Putative beta-hydroxyacid dehydrogenase; Belongs to the HIBADH-related family
    
 
 0.909
yycA
Putative integral inner membrane protein; Putative mannosyltransferase YycA; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme
   
  
 0.906
yngA
Uncharacterized membrane protein YngA; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm: putative membrane component
   
  
 0.905
natR
Two-component system, lyttr family, response regulator natr; Member of the two-component regulatory system NatK/NatR that positively regulates the expression of the natAB operon. Acts by binding directly to the promoter of natAB
      
 0.904
natK
Two-component system, lyttr family, sensor histidine kinase natk; Member of the two-component regulatory system NatK/NatR that positively regulates the expression of the natAB operon. Potentially phosphorylates NatR
      
 0.900
resE
Two-component system, ompr family, sensor histidine kinase rese; Member of the two-component regulatory system ResD/ResE involved in the global regulation of aerobic and anaerobic respiration. Probably phosphorylates ResD
 
 0.844
phoR
Two-component system, ompr family, phosphate regulon sensor histidine kinase phor; Member of the two-component regulatory system PhoP/PhoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates PhoP in response to environmental signals
 
 0.743
yrkQ
Two-component sensor histidine kinase [yrkp]; Member of the two-component regulatory system YrkQ/YrkP. Probably activates YrkP by phosphorylation
 
 
 0.726
Your Current Organism:
Bacillus subtilis
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.