Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
yclKTwo-component sensor histidine kinase [YclJ]; Could be member of the two-component regulatory system YclK/YclJ. Potentially phosphorylates YclJ. (473 aa)    
Predicted Functional Partners:
yclJ
Two-component response regulator [YclK]; Could be member of the two-component regulatory system YclK/YclJ.
 
 0.999
yclH
Putative ABC transporter (ATPase component); Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter; Belongs to the ABC transporter superfamily.
 
  
 0.964
yclI
Putative transporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter.
 
  
 0.962
walR
Two-component response regulator [YycF]; Member of the two-component regulatory system WalK/WalR involved in the regulation of the ftsAZ operon, the yocH, ykvT, cwlO, lytE, ydjM, yjeA, yoeB genes and the tagAB and tagDEF operons. Binds to the ftsAZ P1 promoter sequence in vitro. WalR has been shown to directly bind to the regulatory regions of yocH, ykvT, tagAB/tagDEF. Activates cwlO, lytE and ydjM and represses yoeB and yjeA.
 
 0.953
yycA
Putative integral inner membrane protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme.
  
  
 0.911
yfjR
Putative beta-hydroxyacid dehydrogenase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the HIBADH-related family.
      
 0.908
phoP
Two-component response regulator; Member of the two-component regulatory system PhoP/PhoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase.
 
 0.894
ywpD
Putative two-component sensor histidine kinase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative receptor.
 
    
 0.888
rbsB
Ribose ABC transporter (ribose-binding lipoprotein); Part of the ABC transporter complex RbsABC involved in ribose import. Binds ribose.
 
  
 
 0.885
resD
Two-component response regulator; Member of the two-component regulatory system ResD/ResE. Required for the expression of resA, ctaA, qcrABC and fnr; activation role in global regulation of aerobic and anaerobic respiration.
 
 0.884
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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