STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
phrCPhosphatase RapC inhibitor; Inhibitor of the activity of phosphatase RapC; Belongs to the phr family. (40 aa)    
Predicted Functional Partners:
rapC
Response regulator aspartate phosphatase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the RAP family.
  
 
 0.999
rapJ
Response regulator aspartate phosphatase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme.
   
 
 0.990
rapB
Response regulator aspartate phosphatase; Prevents sporulation by dephosphorylating Spo0F.
   
 
 0.990
rapF
Response regulator aspartate phosphatase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme.
   
  
 0.941
phrF
Secreted regulator of the activity of phosphatase RapF; Inhibitor of the activity of phosphatase RapF; Belongs to the phr family.
   
  
 0.941
phrA
Secreted inhibitor of the activity of phosphatase RapA; Inhibitor of the activity of phosphatase RapA.
   
  
 0.917
comP
Two-component sensor histidine kinase; Sensor in the two-component regulatory system ComP/ComA involved in a major quorum response pathway that regulates the development of genetic competence. Plays a role in sporulation, at least partly interchangeable with that of SpoIIJ. Probably activates ComA by phosphorylation.
   
  
 0.891
phrE
Regulator of the activity of phosphatase RapE; Inhibitor of the activity of phosphatase RapE.
   
  
 0.871
phrK
Secreted regulator of the activity of phosphatase RapK; Inhibitor of the activity of phosphatase RapK.
   
  
 0.849
srfAA
Surfactin synthetase; This protein is a multifunctional enzyme able to activate and polymerize the amino acids Leu, Glu, Asp and Val. Activation sites for these AA consist of individual domains.
   
  
 0.840
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.