| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| csoR | ycnI | BSU33520 | BSU03940 | Repressor of copper utilisation proteins; Copper-sensitive repressor that has a key role in copper homeostasis. Negatively regulates expression of the copZA operon and of ycnJ. In the absence of copper ions, binds with high affinity to the copZA promoter and represses the transcription. In the presence of copper ions, CsoR binds Cu(1+), which significantly decreases its DNA binding affinity and leads to the transcription of the genes. | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. | 0.755 |
| csoR | ycnJ | BSU33520 | BSU03950 | Repressor of copper utilisation proteins; Copper-sensitive repressor that has a key role in copper homeostasis. Negatively regulates expression of the copZA operon and of ycnJ. In the absence of copper ions, binds with high affinity to the copZA promoter and represses the transcription. In the presence of copper ions, CsoR binds Cu(1+), which significantly decreases its DNA binding affinity and leads to the transcription of the genes. | Putative copper import protein; Involved in uptake of extracellular oxidized copper under copper-limiting conditions; In the N-terminal section; belongs to the CopC family. | 0.920 |
| csoR | ycnK | BSU33520 | BSU03960 | Repressor of copper utilisation proteins; Copper-sensitive repressor that has a key role in copper homeostasis. Negatively regulates expression of the copZA operon and of ycnJ. In the absence of copper ions, binds with high affinity to the copZA promoter and represses the transcription. In the presence of copper ions, CsoR binds Cu(1+), which significantly decreases its DNA binding affinity and leads to the transcription of the genes. | Putative transcriptional regulator (DeoR family); May act as a negative transcriptional regulator of ycnJ in the presence of copper. May use copper as a corepressor. | 0.880 |
| csoR | ycnL | BSU33520 | BSU03970 | Repressor of copper utilisation proteins; Copper-sensitive repressor that has a key role in copper homeostasis. Negatively regulates expression of the copZA operon and of ycnJ. In the absence of copper ions, binds with high affinity to the copZA promoter and represses the transcription. In the presence of copper ions, CsoR binds Cu(1+), which significantly decreases its DNA binding affinity and leads to the transcription of the genes. | Putative reductase or disulfide isomerase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. | 0.470 |
| deoR | ycnI | BSU39430 | BSU03940 | Transcriptional regulator; Negative regulator of the dra-nupC-pdp operon. DeoR binds cooperatively to the operator DNA, which consists of a palindrome and a direct repeat sequence located 3' to the palindrome. Belongs to the SorC transcriptional regulatory family. | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. | 0.557 |
| deoR | ycnJ | BSU39430 | BSU03950 | Transcriptional regulator; Negative regulator of the dra-nupC-pdp operon. DeoR binds cooperatively to the operator DNA, which consists of a palindrome and a direct repeat sequence located 3' to the palindrome. Belongs to the SorC transcriptional regulatory family. | Putative copper import protein; Involved in uptake of extracellular oxidized copper under copper-limiting conditions; In the N-terminal section; belongs to the CopC family. | 0.559 |
| deoR | ycnK | BSU39430 | BSU03960 | Transcriptional regulator; Negative regulator of the dra-nupC-pdp operon. DeoR binds cooperatively to the operator DNA, which consists of a palindrome and a direct repeat sequence located 3' to the palindrome. Belongs to the SorC transcriptional regulatory family. | Putative transcriptional regulator (DeoR family); May act as a negative transcriptional regulator of ycnJ in the presence of copper. May use copper as a corepressor. | 0.580 |
| deoR | ycnL | BSU39430 | BSU03970 | Transcriptional regulator; Negative regulator of the dra-nupC-pdp operon. DeoR binds cooperatively to the operator DNA, which consists of a palindrome and a direct repeat sequence located 3' to the palindrome. Belongs to the SorC transcriptional regulatory family. | Putative reductase or disulfide isomerase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. | 0.639 |
| mtlD | ycnL | BSU03990 | BSU03970 | Mannitol-1-phosphate dehydrogenase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. | Putative reductase or disulfide isomerase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. | 0.540 |
| mtlD | ycsA | BSU03990 | BSU04000 | Mannitol-1-phosphate dehydrogenase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. | Putative tartrate dehydrogenase; Has multiple catalytic activities. Apart from catalyzing the oxidation of (+)-tartrate to oxaloglycolate, also converts meso- tartrate to D-glycerate and catalyzes the oxidative decarboxylation of D-malate to pyruvate; Belongs to the isocitrate and isopropylmalate dehydrogenases family. | 0.698 |
| mtlD | ycsN | BSU03990 | BSU04150 | Mannitol-1-phosphate dehydrogenase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. | Putative oxidoreductase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily. | 0.417 |
| ycnI | csoR | BSU03940 | BSU33520 | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. | Repressor of copper utilisation proteins; Copper-sensitive repressor that has a key role in copper homeostasis. Negatively regulates expression of the copZA operon and of ycnJ. In the absence of copper ions, binds with high affinity to the copZA promoter and represses the transcription. In the presence of copper ions, CsoR binds Cu(1+), which significantly decreases its DNA binding affinity and leads to the transcription of the genes. | 0.755 |
| ycnI | deoR | BSU03940 | BSU39430 | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. | Transcriptional regulator; Negative regulator of the dra-nupC-pdp operon. DeoR binds cooperatively to the operator DNA, which consists of a palindrome and a direct repeat sequence located 3' to the palindrome. Belongs to the SorC transcriptional regulatory family. | 0.557 |
| ycnI | ycnJ | BSU03940 | BSU03950 | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. | Putative copper import protein; Involved in uptake of extracellular oxidized copper under copper-limiting conditions; In the N-terminal section; belongs to the CopC family. | 0.999 |
| ycnI | ycnK | BSU03940 | BSU03960 | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. | Putative transcriptional regulator (DeoR family); May act as a negative transcriptional regulator of ycnJ in the presence of copper. May use copper as a corepressor. | 0.998 |
| ycnI | ycnL | BSU03940 | BSU03970 | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. | Putative reductase or disulfide isomerase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. | 0.946 |
| ycnJ | csoR | BSU03950 | BSU33520 | Putative copper import protein; Involved in uptake of extracellular oxidized copper under copper-limiting conditions; In the N-terminal section; belongs to the CopC family. | Repressor of copper utilisation proteins; Copper-sensitive repressor that has a key role in copper homeostasis. Negatively regulates expression of the copZA operon and of ycnJ. In the absence of copper ions, binds with high affinity to the copZA promoter and represses the transcription. In the presence of copper ions, CsoR binds Cu(1+), which significantly decreases its DNA binding affinity and leads to the transcription of the genes. | 0.920 |
| ycnJ | deoR | BSU03950 | BSU39430 | Putative copper import protein; Involved in uptake of extracellular oxidized copper under copper-limiting conditions; In the N-terminal section; belongs to the CopC family. | Transcriptional regulator; Negative regulator of the dra-nupC-pdp operon. DeoR binds cooperatively to the operator DNA, which consists of a palindrome and a direct repeat sequence located 3' to the palindrome. Belongs to the SorC transcriptional regulatory family. | 0.559 |
| ycnJ | ycnI | BSU03950 | BSU03940 | Putative copper import protein; Involved in uptake of extracellular oxidized copper under copper-limiting conditions; In the N-terminal section; belongs to the CopC family. | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. | 0.999 |
| ycnJ | ycnK | BSU03950 | BSU03960 | Putative copper import protein; Involved in uptake of extracellular oxidized copper under copper-limiting conditions; In the N-terminal section; belongs to the CopC family. | Putative transcriptional regulator (DeoR family); May act as a negative transcriptional regulator of ycnJ in the presence of copper. May use copper as a corepressor. | 0.998 |
