STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
topBDNA topoisomerase III; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA su [...] (727 aa)    
Predicted Functional Partners:
recQ
ATP-dependent DNA helicase; Probable DNA helicase. Required in synaptic and/or post- synaptic stages of recombination. Probably has overlapping function with RecQ (AC O34748). It probably acts to help generate ss-DNA from ds-DNA breaks.
 
 0.995
rtbI
Ribonuclease toxin of toxin-antitoxin systems RttI-RttJ; Probable DNA helicase. Required for DNA repair and intramolecular recombination; probably has overlapping function with RecS (AC P50729). It probably acts to help generate ss-DNA from ds-DNA breaks; Belongs to the helicase family. RecQ subfamily.
 
 0.982
leuS
leucyl-tRNA synthetase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the class-I aminoacyl-tRNA synthetase family.
   
 
 0.939
ssbB
Single-strand DNA-binding protein; Not essential for replication of the chromosome, but is required for optimal competence. Binds ssDNA, binding is facilitated by DprA, acts as an accessory factor for homologous DNA strand exchange.
  
 
 0.927
ssbA
Single-strand DNA-binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. Has a 20-fold higher affinity for ssDNA than SsbB; SsbA and DprA activate the homologuos DNA strand exchange function of RecA-ATP.
  
 
 0.922
gltA
Glutamate synthase (large subunit); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the glutamate synthase family.
  
  
 0.911
rpoA
RNA polymerase (alpha subunit); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
  
 
 0.842
lrpC
Transcriptional regulator (Lrp/AsnC family); Transcriptional regulator with a possible role in regulation of amino acid metabolism. Plays a role in the growth phase transition.
  
  
 0.805
spcB
Chromosome condensation and segregation factor; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves; Belongs to the ScpB family.
  
  
 0.734
yrhO
Putative transcriptional regulator; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr: putative regulator.
   
    0.730
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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