STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mntHH(+)-stimulated, divalent metal cation uptake system. Involved in manganese uptake. Can probably also transport cadmium, cobalt, copper and zinc, but not iron. May be the predominant transporter of manganese during logarithmic phase growth (425 aa)    
Predicted Functional Partners:
mntR
Transcriptional regulator (dtxr family); Central regulator of manganese homeostasis that regulates the expression of both manganese uptake and efflux systems . In the presence of high levels of manganese, it mediates repression of the manganese uptake systems MntH and MntABCD and activation of the efflux systems MneP and MneS. Binds with high affinity to the regulatory regions of its target genes . The manganese concentration required for activation of efflux is higher than that for repression of uptake
 
   
 0.979
mntC
Manganese/zinc/iron transport system permease protein; Probably part of the ABC transporter complex MntABCD involved in manganese import. Probably responsible for the translocation of the substrate across the membrane
  
  
 0.961
mgtE
Magnesium transporter mgte; Acts as a magnesium transporter
     
 0.825
mntA
Manganese/zinc/iron transport system substrate-binding protein; Probably part of the ABC transporter complex MntABCD involved in manganese import
  
  
 0.810
hemH
Protoporphyrin/coproporphyrin ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX
  
  
 0.796
sodA
Superoxide dismutase, fe-mn family; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems
   
  
 0.791
mntB
Manganese/zinc/iron transport system atp- binding protein; Probably part of the ABC transporter complex MntABCD involved in manganese import. Probably responsible for energy coupling to the transport system
  
  
 0.771
ywlD
Putative integral inner membrane protein upf0059 duf0204 family; Probably functions as a manganese efflux pump
      
 0.695
panE
2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
      
 0.634
yoeA
Probable multidrug resistance protein YoeA; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter
  
  
 0.592
Your Current Organism:
Bacillus subtilis
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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