STRING protein interaction network
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
protein homology
Your Input:
Gene Fusion
gsiBGlucose starvation-inducible protein b; Involved in an adaptive response to nutrient deprivation other than sporulation (123 aa)    
Predicted Functional Partners:
General stress protein A; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme
50S ribosomal protein L25/general stress protein Ctc; Not required for exponential growth; probably functions in vegetatively growing cells, maybe required for accurate translation under stress conditions
Putative lipid kinase bmru; May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG). In fact, is not able to exhibit diacylglycerol kinase activity in vitro
Ribosome-associated sigma 54 modulation protein; Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth. May not be the only factor implicated . Might negatively regulate the activity of the sigma-54 factor (SigL)
Conserved hypothetical protein; Uncharacterized protein YdbA; Evidence 4: Homologs of previously reported genes of unknown function
Putative nad(p)-dependent dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family
Conserved hypothetical protein; Belongs to the D-lyxose ketol-isomerase family
Putative oxidoreductase; Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily
Rna polymerase sigma-37 factor (sigma(b)); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Sigma B is not essential for sporulation; rather it is required for maximal expression of ctc and csbA which are transcribed in the early stationary phase under conditions inimical to sporulation. May play a role in the ability of the bacterium to adapt to various stresses but is not essential for its survival under these conditions. Positively regulates expression of its own operon
Conserved hypothetical protein; UPF0410 protein YdaS; Evidence 4: Homologs of previously reported genes of unknown function
Your Current Organism:
Bacillus subtilis
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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