node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cimH | citT | BSU38770 | BSU07590 | citrate/malate/H+ symporter; Proton motive force-driven secondary transporter that catalyzes the uptake of both citrate and malate. Appears to be an electroneutral proton-solute symporter; the number of protons transported is equal to the valence of the transported anions. Is strictly stereoselective, translocating only the (S)-enantiomer of malate. | Two-component response regulator; Member of the two-component regulatory system CitT/CitS. Regulates the expression of the citM-yflN operon. Phosphorylated CitT binds to the citM promoter to activate the transcription of the citM- yflN operon. | 0.714 |
cimH | dctR | BSU38770 | BSU04460 | citrate/malate/H+ symporter; Proton motive force-driven secondary transporter that catalyzes the uptake of both citrate and malate. Appears to be an electroneutral proton-solute symporter; the number of protons transported is equal to the valence of the transported anions. Is strictly stereoselective, translocating only the (S)-enantiomer of malate. | Two-component response regulator; Member of the two-component regulatory system DctS/DctR. Essential for expression of dctP. | 0.465 |
cimH | dctS | BSU38770 | BSU04450 | citrate/malate/H+ symporter; Proton motive force-driven secondary transporter that catalyzes the uptake of both citrate and malate. Appears to be an electroneutral proton-solute symporter; the number of protons transported is equal to the valence of the transported anions. Is strictly stereoselective, translocating only the (S)-enantiomer of malate. | Two-component sensor histidine kinase; Member of the two-component regulatory system DctS/DctR. Probably activates DctR by phosphorylation (By similarity). Essential for expression of dctP. | 0.463 |
cimH | yufM | BSU38770 | BSU31530 | citrate/malate/H+ symporter; Proton motive force-driven secondary transporter that catalyzes the uptake of both citrate and malate. Appears to be an electroneutral proton-solute symporter; the number of protons transported is equal to the valence of the transported anions. Is strictly stereoselective, translocating only the (S)-enantiomer of malate. | Two-component response regulator [YufL]; Member of a two-component regulatory system MalK/MalR. Activates transcription of maeA, maeN and yflS in presence of malate by binding to their promoter region. | 0.695 |
citT | cimH | BSU07590 | BSU38770 | Two-component response regulator; Member of the two-component regulatory system CitT/CitS. Regulates the expression of the citM-yflN operon. Phosphorylated CitT binds to the citM promoter to activate the transcription of the citM- yflN operon. | citrate/malate/H+ symporter; Proton motive force-driven secondary transporter that catalyzes the uptake of both citrate and malate. Appears to be an electroneutral proton-solute symporter; the number of protons transported is equal to the valence of the transported anions. Is strictly stereoselective, translocating only the (S)-enantiomer of malate. | 0.714 |
citT | dctS | BSU07590 | BSU04450 | Two-component response regulator; Member of the two-component regulatory system CitT/CitS. Regulates the expression of the citM-yflN operon. Phosphorylated CitT binds to the citM promoter to activate the transcription of the citM- yflN operon. | Two-component sensor histidine kinase; Member of the two-component regulatory system DctS/DctR. Probably activates DctR by phosphorylation (By similarity). Essential for expression of dctP. | 0.867 |
citT | maeN | BSU07590 | BSU31580 | Two-component response regulator; Member of the two-component regulatory system CitT/CitS. Regulates the expression of the citM-yflN operon. Phosphorylated CitT binds to the citM promoter to activate the transcription of the citM- yflN operon. | Na+/malate symporter; Acts as a Na(+)-malate symporter, as it catalyzes malate- dependent uptake of Na(+) and Na(+)-dependent uptake of malate. | 0.491 |
citT | yflP | BSU07590 | BSU07600 | Two-component response regulator; Member of the two-component regulatory system CitT/CitS. Regulates the expression of the citM-yflN operon. Phosphorylated CitT binds to the citM promoter to activate the transcription of the citM- yflN operon. | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; Belongs to the UPF0065 (bug) family. | 0.968 |
dctB | dctP | BSU04440 | BSU04470 | C4-dicarboxylate binding protein; Part of the binding-protein-dependent transport system for uptake of C4-dicarboxylates. Responsible for growth on fumarate and succinate but not malate. Is not directly involved in C4-dicarboxylate uptake, but plays a sensory role in the DctS/DctR two-component system which regulates the expression of the dctA C4-dicarboxylate transporter; Belongs to the bacterial solute-binding protein 7 family. | C4-dicarboxylate transport protein; Responsible for the transport of succinate and fumarate, but not malate, across the membrane. | 0.916 |
dctB | dctR | BSU04440 | BSU04460 | C4-dicarboxylate binding protein; Part of the binding-protein-dependent transport system for uptake of C4-dicarboxylates. Responsible for growth on fumarate and succinate but not malate. Is not directly involved in C4-dicarboxylate uptake, but plays a sensory role in the DctS/DctR two-component system which regulates the expression of the dctA C4-dicarboxylate transporter; Belongs to the bacterial solute-binding protein 7 family. | Two-component response regulator; Member of the two-component regulatory system DctS/DctR. Essential for expression of dctP. | 0.912 |
dctB | dctS | BSU04440 | BSU04450 | C4-dicarboxylate binding protein; Part of the binding-protein-dependent transport system for uptake of C4-dicarboxylates. Responsible for growth on fumarate and succinate but not malate. Is not directly involved in C4-dicarboxylate uptake, but plays a sensory role in the DctS/DctR two-component system which regulates the expression of the dctA C4-dicarboxylate transporter; Belongs to the bacterial solute-binding protein 7 family. | Two-component sensor histidine kinase; Member of the two-component regulatory system DctS/DctR. Probably activates DctR by phosphorylation (By similarity). Essential for expression of dctP. | 0.991 |
dctB | yflP | BSU04440 | BSU07600 | C4-dicarboxylate binding protein; Part of the binding-protein-dependent transport system for uptake of C4-dicarboxylates. Responsible for growth on fumarate and succinate but not malate. Is not directly involved in C4-dicarboxylate uptake, but plays a sensory role in the DctS/DctR two-component system which regulates the expression of the dctA C4-dicarboxylate transporter; Belongs to the bacterial solute-binding protein 7 family. | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; Belongs to the UPF0065 (bug) family. | 0.505 |
dctP | dctB | BSU04470 | BSU04440 | C4-dicarboxylate transport protein; Responsible for the transport of succinate and fumarate, but not malate, across the membrane. | C4-dicarboxylate binding protein; Part of the binding-protein-dependent transport system for uptake of C4-dicarboxylates. Responsible for growth on fumarate and succinate but not malate. Is not directly involved in C4-dicarboxylate uptake, but plays a sensory role in the DctS/DctR two-component system which regulates the expression of the dctA C4-dicarboxylate transporter; Belongs to the bacterial solute-binding protein 7 family. | 0.916 |
dctP | dctR | BSU04470 | BSU04460 | C4-dicarboxylate transport protein; Responsible for the transport of succinate and fumarate, but not malate, across the membrane. | Two-component response regulator; Member of the two-component regulatory system DctS/DctR. Essential for expression of dctP. | 0.769 |
dctP | dctS | BSU04470 | BSU04450 | C4-dicarboxylate transport protein; Responsible for the transport of succinate and fumarate, but not malate, across the membrane. | Two-component sensor histidine kinase; Member of the two-component regulatory system DctS/DctR. Probably activates DctR by phosphorylation (By similarity). Essential for expression of dctP. | 0.951 |
dctR | cimH | BSU04460 | BSU38770 | Two-component response regulator; Member of the two-component regulatory system DctS/DctR. Essential for expression of dctP. | citrate/malate/H+ symporter; Proton motive force-driven secondary transporter that catalyzes the uptake of both citrate and malate. Appears to be an electroneutral proton-solute symporter; the number of protons transported is equal to the valence of the transported anions. Is strictly stereoselective, translocating only the (S)-enantiomer of malate. | 0.465 |
dctR | dctB | BSU04460 | BSU04440 | Two-component response regulator; Member of the two-component regulatory system DctS/DctR. Essential for expression of dctP. | C4-dicarboxylate binding protein; Part of the binding-protein-dependent transport system for uptake of C4-dicarboxylates. Responsible for growth on fumarate and succinate but not malate. Is not directly involved in C4-dicarboxylate uptake, but plays a sensory role in the DctS/DctR two-component system which regulates the expression of the dctA C4-dicarboxylate transporter; Belongs to the bacterial solute-binding protein 7 family. | 0.912 |
dctR | dctP | BSU04460 | BSU04470 | Two-component response regulator; Member of the two-component regulatory system DctS/DctR. Essential for expression of dctP. | C4-dicarboxylate transport protein; Responsible for the transport of succinate and fumarate, but not malate, across the membrane. | 0.769 |
dctR | dctS | BSU04460 | BSU04450 | Two-component response regulator; Member of the two-component regulatory system DctS/DctR. Essential for expression of dctP. | Two-component sensor histidine kinase; Member of the two-component regulatory system DctS/DctR. Probably activates DctR by phosphorylation (By similarity). Essential for expression of dctP. | 0.999 |
dctR | maeN | BSU04460 | BSU31580 | Two-component response regulator; Member of the two-component regulatory system DctS/DctR. Essential for expression of dctP. | Na+/malate symporter; Acts as a Na(+)-malate symporter, as it catalyzes malate- dependent uptake of Na(+) and Na(+)-dependent uptake of malate. | 0.488 |