Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
rapIResponse regulator aspartate phosphatase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type r: regulator; Belongs to the RAP family. (391 aa)    
Predicted Functional Partners:
phrI
Secreted regulator of the activity of phosphatase RapI; Inhibitor of the activity of phosphatase RapI.
  
  
 0.996
immR
Phage element (ICEBs1)transcriptional regulator (Xre family); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type h: extrachromosomal origin.
   
  
 0.984
yddM
Putative helicase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme.
  
  
 0.975
sacV
Transcriptional regulator; Required for the excision of the integrative and conjugative element ICEBs1. Excision of ICEBs1 requires two sites, attL and attR, at the left and right ends of the integrated ICEBs1.
   
  
 0.914
ydcR
Putative replication protein; Probable DNA relaxase involved in the transfer of the integrative and conjugative element ICEBs1. Required for the transfer of ICEBs1. Probably mediates conjugation of ICEBs1 by nicking at oriT on the conjugative element and facilitates the translocation of a single strand of ICEBs1 DNA through a transmembrane conjugation pore into the recipient cell; Belongs to the plasmid replication initiation factor family.
   
  
 0.913
yddJ
Putative lipoprotein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp: lipoprotein.
   
  
 0.878
yddK
Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function.
  
  
 0.866
spo0F
Two-component response regulator; Key element in the phosphorelay regulating sporulation initiation. Phosphorylation of spo0B during sporulation initiation.
   
 
 0.844
immA
Site-specific protease cleaving ImmR; Involved in the regulation of horizontal gene transfer through the integrative and conjugative element ICEBs1. Required for degradation of the ICEBs1 repressor protein ImmR/YdcN.
   
  
 0.791
phrF
Secreted regulator of the activity of phosphatase RapF; Inhibitor of the activity of phosphatase RapF; Belongs to the phr family.
      
 0.782
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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