STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ydfHTwo-component system, narl family, sensor histidine kinase ydfh; Member of the two-component regulatory system YdfH/YdfI. May activate YdfI by phosphorylation (407 aa)    
Predicted Functional Partners:
ydfI
Two-component system, narl family, response regulator ydfi; Member of the two-component regulatory system YdfH/YdfI. Regulates the transcription of ydfJ by binding to its promoter region
 0.998
ureA
Urease (gamma subunit); Belongs to the urease gamma subunit family
      
 0.900
ybdK
Two-component sensor histidine kinase [ybdj]; Member of the two-component regulatory system YbdK/YbdJ. Probably activates YbdJ by phosphorylation
    
 
 0.898
ybdJ
Two-component system, ompr family, response regulator; Member of the two-component regulatory system YbdK/YbdJ
 
  
 
 0.894
ytzD
Uncharacterized protein YtzD; Evidence 5: No homology to any previously reported sequences; PubMedId: 11423008
      
 0.881
liaR
Two-component response regulator [yvqe] responding to cell wall stress; Member of the two-component regulatory system LiaS/LiaR probably involved in response to a subset of cell wall-active antibiotics that interfere with the lipid II cycle in the cytoplasmic membrane (bacitracin, nisin, ramoplanin and vancomycin). Seems also involved in response to cationic antimicrobial peptides and secretion stress. LiaR regulates the transcription of the liaIHGFSR operon
 
 0.831
comA
Two-component system, narl family, competent response regulator coma; Response regulator in the two-component regulatory system ComP/ComA involved in a major quorum response pathway that regulates the development of genetic competence. Regulates directly the expression of over 20 genes, including genes of the srfA operon, degQ, rapA, rapC, rapE, rapF, etc. Regulates indirectly, through the regulation of comK transcription, the expression of late competence genes
 
 0.797
yhcZ
Two-component system, narl family, response regulator; Member of the two-component regulatory system YhcY/YhcZ
 
 0.782
yxjL
Two-component system, narl family, response regulator; Probable member of the two-component regulatory system YxjM/YxjL
 
 0.772
yfiK
Two-component system, narl family, response regulator; Required for resistance to linearmycins, a family of antibiotic-specialized metabolites produced by some streptomycetes . Member of the two-component regulatory system LnrJ/LnrK, which induces expression of the LnrLMN ABC transporter in response to linearmycins and other polyenes . Probably binds to the promoter region of the lnrLMN operon and directly regulates its expression (Probable). May also promote biofilm formation
 
 0.771
Your Current Organism:
Bacillus subtilis
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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