node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
comA | ydfH | BSU31680 | BSU05410 | Two-component response regulator; Response regulator in the two-component regulatory system ComP/ComA involved in a major quorum response pathway that regulates the development of genetic competence. Regulates directly the expression of over 20 genes, including genes of the srfA operon, degQ, rapA, rapC, rapE, rapF, etc. Regulates indirectly, through the regulation of comK transcription, the expression of late competence genes. | Two-component sensor histidine kinase [YdfI]; Member of the two-component regulatory system YdfH/YdfI. May activate YdfI by phosphorylation. | 0.819 |
desR | ydfH | BSU19200 | BSU05410 | Two-component response regulator [DesK]; Member of the two-component regulatory system DesR/DesK, responsible for cold induction of the des gene coding for the Delta5 acyl-lipid desaturase. | Two-component sensor histidine kinase [YdfI]; Member of the two-component regulatory system YdfH/YdfI. May activate YdfI by phosphorylation. | 0.819 |
liaR | ydfH | BSU33080 | BSU05410 | Two-component response regulator [YvqE] responding to cell wall stress; Member of the two-component regulatory system LiaS/LiaR probably involved in response to a subset of cell wall-active antibiotics that interfere with the lipid II cycle in the cytoplasmic membrane (bacitracin, nisin, ramoplanin and vancomycin). Seems also involved in response to cationic antimicrobial peptides and secretion stress. LiaR regulates the transcription of the liaIHGFSR operon. | Two-component sensor histidine kinase [YdfI]; Member of the two-component regulatory system YdfH/YdfI. May activate YdfI by phosphorylation. | 0.819 |
ureA | ydfH | BSU36660 | BSU05410 | Urease (gamma subunit); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the urease gamma subunit family. | Two-component sensor histidine kinase [YdfI]; Member of the two-component regulatory system YdfH/YdfI. May activate YdfI by phosphorylation. | 0.846 |
ureA | ytzD | BSU36660 | BSU29430 | Urease (gamma subunit); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the urease gamma subunit family. | Hypothetical protein; Evidence 5: No homology to any previously reported sequences; PubMedId: 11423008. | 0.830 |
ydfH | comA | BSU05410 | BSU31680 | Two-component sensor histidine kinase [YdfI]; Member of the two-component regulatory system YdfH/YdfI. May activate YdfI by phosphorylation. | Two-component response regulator; Response regulator in the two-component regulatory system ComP/ComA involved in a major quorum response pathway that regulates the development of genetic competence. Regulates directly the expression of over 20 genes, including genes of the srfA operon, degQ, rapA, rapC, rapE, rapF, etc. Regulates indirectly, through the regulation of comK transcription, the expression of late competence genes. | 0.819 |
ydfH | desR | BSU05410 | BSU19200 | Two-component sensor histidine kinase [YdfI]; Member of the two-component regulatory system YdfH/YdfI. May activate YdfI by phosphorylation. | Two-component response regulator [DesK]; Member of the two-component regulatory system DesR/DesK, responsible for cold induction of the des gene coding for the Delta5 acyl-lipid desaturase. | 0.819 |
ydfH | liaR | BSU05410 | BSU33080 | Two-component sensor histidine kinase [YdfI]; Member of the two-component regulatory system YdfH/YdfI. May activate YdfI by phosphorylation. | Two-component response regulator [YvqE] responding to cell wall stress; Member of the two-component regulatory system LiaS/LiaR probably involved in response to a subset of cell wall-active antibiotics that interfere with the lipid II cycle in the cytoplasmic membrane (bacitracin, nisin, ramoplanin and vancomycin). Seems also involved in response to cationic antimicrobial peptides and secretion stress. LiaR regulates the transcription of the liaIHGFSR operon. | 0.819 |
ydfH | ureA | BSU05410 | BSU36660 | Two-component sensor histidine kinase [YdfI]; Member of the two-component regulatory system YdfH/YdfI. May activate YdfI by phosphorylation. | Urease (gamma subunit); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the urease gamma subunit family. | 0.846 |
ydfH | ydfI | BSU05410 | BSU05420 | Two-component sensor histidine kinase [YdfI]; Member of the two-component regulatory system YdfH/YdfI. May activate YdfI by phosphorylation. | Two-component response regulator [YdfH]; Member of the two-component regulatory system YdfH/YdfI. Regulates the transcription of ydfJ by binding to its promoter region. | 0.997 |
ydfH | yfiK | BSU05410 | BSU08300 | Two-component sensor histidine kinase [YdfI]; Member of the two-component regulatory system YdfH/YdfI. May activate YdfI by phosphorylation. | Two-component response regulator [YfiJ]; Required for resistance to linearmycins, a family of antibiotic-specialized metabolites produced by some streptomycetes. Member of the two-component regulatory system LnrJ/LnrK, which induces expression of the LnrLMN ABC transporter in response to linearmycins and other polyenes. Probably binds to the promoter region of the lnrLMN operon and directly regulates its expression (Probable). May also promote biofilm formation. | 0.819 |
ydfH | yhcZ | BSU05410 | BSU09330 | Two-component sensor histidine kinase [YdfI]; Member of the two-component regulatory system YdfH/YdfI. May activate YdfI by phosphorylation. | Two-component response regulator [YhcY]; Member of the two-component regulatory system YhcY/YhcZ. | 0.819 |
ydfH | ytzD | BSU05410 | BSU29430 | Two-component sensor histidine kinase [YdfI]; Member of the two-component regulatory system YdfH/YdfI. May activate YdfI by phosphorylation. | Hypothetical protein; Evidence 5: No homology to any previously reported sequences; PubMedId: 11423008. | 0.845 |
ydfH | yvfU | BSU05410 | BSU34060 | Two-component sensor histidine kinase [YdfI]; Member of the two-component regulatory system YdfH/YdfI. May activate YdfI by phosphorylation. | Two-component response regulator [YvfT]; Member of the two-component regulatory system YvfT/YvfU. | 0.844 |
ydfH | yxjL | BSU05410 | BSU38910 | Two-component sensor histidine kinase [YdfI]; Member of the two-component regulatory system YdfH/YdfI. May activate YdfI by phosphorylation. | Two-component response regulator [YxjM]; Probable member of the two-component regulatory system YxjM/YxjL. | 0.820 |
ydfI | ydfH | BSU05420 | BSU05410 | Two-component response regulator [YdfH]; Member of the two-component regulatory system YdfH/YdfI. Regulates the transcription of ydfJ by binding to its promoter region. | Two-component sensor histidine kinase [YdfI]; Member of the two-component regulatory system YdfH/YdfI. May activate YdfI by phosphorylation. | 0.997 |
yfiK | ydfH | BSU08300 | BSU05410 | Two-component response regulator [YfiJ]; Required for resistance to linearmycins, a family of antibiotic-specialized metabolites produced by some streptomycetes. Member of the two-component regulatory system LnrJ/LnrK, which induces expression of the LnrLMN ABC transporter in response to linearmycins and other polyenes. Probably binds to the promoter region of the lnrLMN operon and directly regulates its expression (Probable). May also promote biofilm formation. | Two-component sensor histidine kinase [YdfI]; Member of the two-component regulatory system YdfH/YdfI. May activate YdfI by phosphorylation. | 0.819 |
yhcZ | ydfH | BSU09330 | BSU05410 | Two-component response regulator [YhcY]; Member of the two-component regulatory system YhcY/YhcZ. | Two-component sensor histidine kinase [YdfI]; Member of the two-component regulatory system YdfH/YdfI. May activate YdfI by phosphorylation. | 0.819 |
ytzD | ureA | BSU29430 | BSU36660 | Hypothetical protein; Evidence 5: No homology to any previously reported sequences; PubMedId: 11423008. | Urease (gamma subunit); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the urease gamma subunit family. | 0.830 |
ytzD | ydfH | BSU29430 | BSU05410 | Hypothetical protein; Evidence 5: No homology to any previously reported sequences; PubMedId: 11423008. | Two-component sensor histidine kinase [YdfI]; Member of the two-component regulatory system YdfH/YdfI. May activate YdfI by phosphorylation. | 0.845 |