Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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ydfJPutative proton metabolite efflux transporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MmpL subfamily. (724 aa)    
Predicted Functional Partners:
ydfI
Two-component response regulator [YdfH]; Member of the two-component regulatory system YdfH/YdfI. Regulates the transcription of ydfJ by binding to its promoter region.
  
  
 0.917
ytxK
Putative nucleic acid methyltransferase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; To type I restriction system adenine methylases.
      
 0.909
paiA
Polyamine N-acetyltransferase; Involved in the protection against polyamine toxicity by regulating their concentration. Also could be involved in the negative control of sporulation as well as production of degradative enzymes such as alpha-amylase, levansucrase and alkaline phosphatase. Catalyzes the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to an acceptor substrate and releases both CoA and the acetylated product. It possesses N1-acetyltransferase activity toward polyamine substrates including spermidine, spermine, aminopropylcadaverine, norspermidine, homospermidine [...]
      
 0.637
trmB
tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
  
  
 0.555
feuA
Iron hydroxamate-binding lipoprotein; Involved in the uptake of iron. Belongs to the bacterial solute-binding protein 8 family.
  
   
 0.540
ydfH
Two-component sensor histidine kinase [YdfI]; Member of the two-component regulatory system YdfH/YdfI. May activate YdfI by phosphorylation.
  
    0.528
epsJ
Putative glycosyl transferase; May be involved in the production of the exopolysaccharide (EPS) component of the extracellular matrix during biofilm formation. EPS is responsible for the adhesion of chains of cells into bundles; Belongs to the glycosyltransferase 2 family.
      
 0.519
pksJ
Polyketide synthase of type I; Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism.
   
 
 0.490
ctpA
Carboxy-terminal processing protease; Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; enzyme.
     
 0.489
glnQ
Glutamine ABC transporter (ATP-binding protein); Part of the ABC transporter complex GlnHMPQ involved in glutamine transport. Probably responsible for energy coupling to the transport system (By similarity).
   
  
 0.486
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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