| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| bst | dinB | BSU08390 | BSU05630 | Bacillithiol S-transferase; Possible metal-dependent hydrolase; Belongs to the metal hydrolase YfiT family. | Nuclease inhibitor; Evidence 2b: Function of strongly homologous gene; regulator. | 0.869 |
| bst | yjoA | BSU08390 | BSU12410 | Bacillithiol S-transferase; Possible metal-dependent hydrolase; Belongs to the metal hydrolase YfiT family. | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. | 0.742 |
| dinB | bst | BSU05630 | BSU08390 | Nuclease inhibitor; Evidence 2b: Function of strongly homologous gene; regulator. | Bacillithiol S-transferase; Possible metal-dependent hydrolase; Belongs to the metal hydrolase YfiT family. | 0.869 |
| dinB | lexA | BSU05630 | BSU17850 | Nuclease inhibitor; Evidence 2b: Function of strongly homologous gene; regulator. | Transcriptional repressor of the SOS regulon; Represses dinA, dinB, dinC, recA genes and itself by binding to the 14 bp palindromic sequence 5'-CGAACNNNNGTTCG-3'; some genes have a tandem consensus sequence and their binding is cooperative. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair; autocleavage is maximal at pH 11 in the absence of RecA and ssDNA. | 0.758 |
| dinB | recA | BSU05630 | BSU16940 | Nuclease inhibitor; Evidence 2b: Function of strongly homologous gene; regulator. | Multifunctional SOS repair factor; Multifunctional protein involved in homologous recombination, DNA repair and competence. Can catalyze the hydrolysis of (d)ATP in the presence of single-stranded DNA; prefers dATP at least in vitro, catalyzes the dATP-dependent uptake of single- stranded DNA by duplex DNA, and the dATP-dependent hybridization of homologous single-stranded DNAs (strand exchange). RecA-ATP cannot catalyze homologous DNA strand exchange; SsbA and DprA activate strand exchange by RecA-ATP. It interacts with LexA causing its activation and leading to its autocatalytic clea [...] | 0.785 |
| dinB | tagC | BSU05630 | BSU35770 | Nuclease inhibitor; Evidence 2b: Function of strongly homologous gene; regulator. | Putative polyglycerol phosphate assembly and export protein (teichoic acid biosynthesis); Unknown. Might be involved in poly(glycerol phosphate) teichoic acid biosynthesis. | 0.963 |
| dinB | uvrB | BSU05630 | BSU35170 | Nuclease inhibitor; Evidence 2b: Function of strongly homologous gene; regulator. | Excinuclease ABC (subunit B); The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociat [...] | 0.726 |
| dinB | yhaZ | BSU05630 | BSU09810 | Nuclease inhibitor; Evidence 2b: Function of strongly homologous gene; regulator. | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; PubMedId: 16267290. | 0.687 |
| dinB | yhjD | BSU05630 | BSU10470 | Nuclease inhibitor; Evidence 2b: Function of strongly homologous gene; regulator. | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; PubMedId: 16267290. | 0.566 |
| dinB | yjoA | BSU05630 | BSU12410 | Nuclease inhibitor; Evidence 2b: Function of strongly homologous gene; regulator. | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. | 0.717 |
| dinB | yneA | BSU05630 | BSU17860 | Nuclease inhibitor; Evidence 2b: Function of strongly homologous gene; regulator. | Cell division inhibitor; Inhibits cell division during the SOS response. Affects a later stage of the cell division protein assembly, after the assembly of the Z ring, by probably suppressing recruitment of FtsL and/or DivIC to the division machinery (By similarity). | 0.835 |
| dinB | yneB | BSU05630 | BSU17870 | Nuclease inhibitor; Evidence 2b: Function of strongly homologous gene; regulator. | Putative cell division protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type cp: cell process. | 0.785 |
| lexA | dinB | BSU17850 | BSU05630 | Transcriptional repressor of the SOS regulon; Represses dinA, dinB, dinC, recA genes and itself by binding to the 14 bp palindromic sequence 5'-CGAACNNNNGTTCG-3'; some genes have a tandem consensus sequence and their binding is cooperative. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair; autocleavage is maximal at pH 11 in the absence of RecA and ssDNA. | Nuclease inhibitor; Evidence 2b: Function of strongly homologous gene; regulator. | 0.758 |
| lexA | recA | BSU17850 | BSU16940 | Transcriptional repressor of the SOS regulon; Represses dinA, dinB, dinC, recA genes and itself by binding to the 14 bp palindromic sequence 5'-CGAACNNNNGTTCG-3'; some genes have a tandem consensus sequence and their binding is cooperative. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair; autocleavage is maximal at pH 11 in the absence of RecA and ssDNA. | Multifunctional SOS repair factor; Multifunctional protein involved in homologous recombination, DNA repair and competence. Can catalyze the hydrolysis of (d)ATP in the presence of single-stranded DNA; prefers dATP at least in vitro, catalyzes the dATP-dependent uptake of single- stranded DNA by duplex DNA, and the dATP-dependent hybridization of homologous single-stranded DNAs (strand exchange). RecA-ATP cannot catalyze homologous DNA strand exchange; SsbA and DprA activate strand exchange by RecA-ATP. It interacts with LexA causing its activation and leading to its autocatalytic clea [...] | 0.999 |
| lexA | tagC | BSU17850 | BSU35770 | Transcriptional repressor of the SOS regulon; Represses dinA, dinB, dinC, recA genes and itself by binding to the 14 bp palindromic sequence 5'-CGAACNNNNGTTCG-3'; some genes have a tandem consensus sequence and their binding is cooperative. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair; autocleavage is maximal at pH 11 in the absence of RecA and ssDNA. | Putative polyglycerol phosphate assembly and export protein (teichoic acid biosynthesis); Unknown. Might be involved in poly(glycerol phosphate) teichoic acid biosynthesis. | 0.760 |
| lexA | uvrB | BSU17850 | BSU35170 | Transcriptional repressor of the SOS regulon; Represses dinA, dinB, dinC, recA genes and itself by binding to the 14 bp palindromic sequence 5'-CGAACNNNNGTTCG-3'; some genes have a tandem consensus sequence and their binding is cooperative. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair; autocleavage is maximal at pH 11 in the absence of RecA and ssDNA. | Excinuclease ABC (subunit B); The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociat [...] | 0.932 |
| lexA | yhaZ | BSU17850 | BSU09810 | Transcriptional repressor of the SOS regulon; Represses dinA, dinB, dinC, recA genes and itself by binding to the 14 bp palindromic sequence 5'-CGAACNNNNGTTCG-3'; some genes have a tandem consensus sequence and their binding is cooperative. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair; autocleavage is maximal at pH 11 in the absence of RecA and ssDNA. | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; PubMedId: 16267290. | 0.488 |
| lexA | yneA | BSU17850 | BSU17860 | Transcriptional repressor of the SOS regulon; Represses dinA, dinB, dinC, recA genes and itself by binding to the 14 bp palindromic sequence 5'-CGAACNNNNGTTCG-3'; some genes have a tandem consensus sequence and their binding is cooperative. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair; autocleavage is maximal at pH 11 in the absence of RecA and ssDNA. | Cell division inhibitor; Inhibits cell division during the SOS response. Affects a later stage of the cell division protein assembly, after the assembly of the Z ring, by probably suppressing recruitment of FtsL and/or DivIC to the division machinery (By similarity). | 0.972 |
| lexA | yneB | BSU17850 | BSU17870 | Transcriptional repressor of the SOS regulon; Represses dinA, dinB, dinC, recA genes and itself by binding to the 14 bp palindromic sequence 5'-CGAACNNNNGTTCG-3'; some genes have a tandem consensus sequence and their binding is cooperative. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair; autocleavage is maximal at pH 11 in the absence of RecA and ssDNA. | Putative cell division protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type cp: cell process. | 0.894 |
| recA | dinB | BSU16940 | BSU05630 | Multifunctional SOS repair factor; Multifunctional protein involved in homologous recombination, DNA repair and competence. Can catalyze the hydrolysis of (d)ATP in the presence of single-stranded DNA; prefers dATP at least in vitro, catalyzes the dATP-dependent uptake of single- stranded DNA by duplex DNA, and the dATP-dependent hybridization of homologous single-stranded DNAs (strand exchange). RecA-ATP cannot catalyze homologous DNA strand exchange; SsbA and DprA activate strand exchange by RecA-ATP. It interacts with LexA causing its activation and leading to its autocatalytic clea [...] | Nuclease inhibitor; Evidence 2b: Function of strongly homologous gene; regulator. | 0.785 |
