node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
gabP | yeaB | BSU06310 | BSU06320 | Gamma-aminobutyrate (GABA) permease; High-affinity uptake system for GABA. Functions also as a low-affinity proline importer; Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family. | Putative cation efflux transporter; Secondary manganese efflux system. May prevent manganese intoxication; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. | 0.653 |
gabP | yeaC | BSU06310 | BSU06330 | Gamma-aminobutyrate (GABA) permease; High-affinity uptake system for GABA. Functions also as a low-affinity proline importer; Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family. | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; Belongs to the MoxR family. | 0.615 |
gabP | yebA | BSU06310 | BSU06350 | Gamma-aminobutyrate (GABA) permease; High-affinity uptake system for GABA. Functions also as a low-affinity proline importer; Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family. | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. | 0.597 |
ldh | yeaB | BSU03050 | BSU06320 | L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. | Putative cation efflux transporter; Secondary manganese efflux system. May prevent manganese intoxication; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. | 0.575 |
mntH | mntR | BSU04360 | BSU24520 | Manganese transporter; H(+)-stimulated, divalent metal cation uptake system. Involved in manganese uptake. Can probably also transport cadmium, cobalt, copper and zinc, but not iron. May be the predominant transporter of manganese during logarithmic phase growth. | Transcriptional regulator (DtxR family); Central regulator of manganese homeostasis that regulates the expression of both manganese uptake and efflux systems. In the presence of high levels of manganese, it mediates repression of the manganese uptake systems MntH and MntABCD and activation of the efflux systems MneP and MneS. Binds with high affinity to the regulatory regions of its target genes. The manganese concentration required for activation of efflux is higher than that for repression of uptake ; Belongs to the DtxR/MntR family. | 0.988 |
mntH | yceF | BSU04360 | BSU02920 | Manganese transporter; H(+)-stimulated, divalent metal cation uptake system. Involved in manganese uptake. Can probably also transport cadmium, cobalt, copper and zinc, but not iron. May be the predominant transporter of manganese during logarithmic phase growth. | Putative stress adaptation transporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. | 0.487 |
mntH | yeaB | BSU04360 | BSU06320 | Manganese transporter; H(+)-stimulated, divalent metal cation uptake system. Involved in manganese uptake. Can probably also transport cadmium, cobalt, copper and zinc, but not iron. May be the predominant transporter of manganese during logarithmic phase growth. | Putative cation efflux transporter; Secondary manganese efflux system. May prevent manganese intoxication; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. | 0.915 |
mntH | ykoY | BSU04360 | BSU13440 | Manganese transporter; H(+)-stimulated, divalent metal cation uptake system. Involved in manganese uptake. Can probably also transport cadmium, cobalt, copper and zinc, but not iron. May be the predominant transporter of manganese during logarithmic phase growth. | Putative transporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. | 0.848 |
mntH | ywlD | BSU04360 | BSU36940 | Manganese transporter; H(+)-stimulated, divalent metal cation uptake system. Involved in manganese uptake. Can probably also transport cadmium, cobalt, copper and zinc, but not iron. May be the predominant transporter of manganese during logarithmic phase growth. | Putative integral inner membrane protein UPF0059 DUF0204 family; Probably functions as a manganese efflux pump. Belongs to the MntP (TC 9.B.29) family. | 0.901 |
mntH | yybP | BSU04360 | BSU40560 | Manganese transporter; H(+)-stimulated, divalent metal cation uptake system. Involved in manganese uptake. Can probably also transport cadmium, cobalt, copper and zinc, but not iron. May be the predominant transporter of manganese during logarithmic phase growth. | Putative lipoprotein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. | 0.745 |
mntR | mntH | BSU24520 | BSU04360 | Transcriptional regulator (DtxR family); Central regulator of manganese homeostasis that regulates the expression of both manganese uptake and efflux systems. In the presence of high levels of manganese, it mediates repression of the manganese uptake systems MntH and MntABCD and activation of the efflux systems MneP and MneS. Binds with high affinity to the regulatory regions of its target genes. The manganese concentration required for activation of efflux is higher than that for repression of uptake ; Belongs to the DtxR/MntR family. | Manganese transporter; H(+)-stimulated, divalent metal cation uptake system. Involved in manganese uptake. Can probably also transport cadmium, cobalt, copper and zinc, but not iron. May be the predominant transporter of manganese during logarithmic phase growth. | 0.988 |
mntR | yeaB | BSU24520 | BSU06320 | Transcriptional regulator (DtxR family); Central regulator of manganese homeostasis that regulates the expression of both manganese uptake and efflux systems. In the presence of high levels of manganese, it mediates repression of the manganese uptake systems MntH and MntABCD and activation of the efflux systems MneP and MneS. Binds with high affinity to the regulatory regions of its target genes. The manganese concentration required for activation of efflux is higher than that for repression of uptake ; Belongs to the DtxR/MntR family. | Putative cation efflux transporter; Secondary manganese efflux system. May prevent manganese intoxication; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. | 0.921 |
mntR | ykoY | BSU24520 | BSU13440 | Transcriptional regulator (DtxR family); Central regulator of manganese homeostasis that regulates the expression of both manganese uptake and efflux systems. In the presence of high levels of manganese, it mediates repression of the manganese uptake systems MntH and MntABCD and activation of the efflux systems MneP and MneS. Binds with high affinity to the regulatory regions of its target genes. The manganese concentration required for activation of efflux is higher than that for repression of uptake ; Belongs to the DtxR/MntR family. | Putative transporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. | 0.849 |
mntR | ywlD | BSU24520 | BSU36940 | Transcriptional regulator (DtxR family); Central regulator of manganese homeostasis that regulates the expression of both manganese uptake and efflux systems. In the presence of high levels of manganese, it mediates repression of the manganese uptake systems MntH and MntABCD and activation of the efflux systems MneP and MneS. Binds with high affinity to the regulatory regions of its target genes. The manganese concentration required for activation of efflux is higher than that for repression of uptake ; Belongs to the DtxR/MntR family. | Putative integral inner membrane protein UPF0059 DUF0204 family; Probably functions as a manganese efflux pump. Belongs to the MntP (TC 9.B.29) family. | 0.941 |
mntR | yybP | BSU24520 | BSU40560 | Transcriptional regulator (DtxR family); Central regulator of manganese homeostasis that regulates the expression of both manganese uptake and efflux systems. In the presence of high levels of manganese, it mediates repression of the manganese uptake systems MntH and MntABCD and activation of the efflux systems MneP and MneS. Binds with high affinity to the regulatory regions of its target genes. The manganese concentration required for activation of efflux is higher than that for repression of uptake ; Belongs to the DtxR/MntR family. | Putative lipoprotein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. | 0.751 |
yceF | mntH | BSU02920 | BSU04360 | Putative stress adaptation transporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. | Manganese transporter; H(+)-stimulated, divalent metal cation uptake system. Involved in manganese uptake. Can probably also transport cadmium, cobalt, copper and zinc, but not iron. May be the predominant transporter of manganese during logarithmic phase growth. | 0.487 |
yceF | yeaB | BSU02920 | BSU06320 | Putative stress adaptation transporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. | Putative cation efflux transporter; Secondary manganese efflux system. May prevent manganese intoxication; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. | 0.890 |
yceF | yybP | BSU02920 | BSU40560 | Putative stress adaptation transporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. | Putative lipoprotein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. | 0.483 |
yeaB | gabP | BSU06320 | BSU06310 | Putative cation efflux transporter; Secondary manganese efflux system. May prevent manganese intoxication; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. | Gamma-aminobutyrate (GABA) permease; High-affinity uptake system for GABA. Functions also as a low-affinity proline importer; Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family. | 0.653 |
yeaB | ldh | BSU06320 | BSU03050 | Putative cation efflux transporter; Secondary manganese efflux system. May prevent manganese intoxication; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. | L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. | 0.575 |