STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yeeFPutative dna binding protein; Probable toxic component of a type II toxin-antitoxin (TA) system. The C-terminus (residues 500-669) may have RNase activity and probably inhibits growth. Its toxic effects are probably neutralized by its cognate antitoxin YezG, but not by antitoxins specific to other toxins with the LXG domain (Probable) (669 aa)    
Predicted Functional Partners:
yezG
Conserved hypothetical protein; Probable antitoxin component of a type II toxin-antitoxin (TA) system. Probably neutralizes the ability to inhibit growth of cognate toxin YeeF. Probably does not have antitoxin activity on other toxins with the LXG toxin domain (Probable)
 
 
 
 0.997
rttM
Antitoxin inhibiting rnase rttl; Antitoxin component of a type II toxin-antitoxin (TA) system. Neutralizes the RNase activity of cognate toxin YobL, as well as its ability to inhibit growth upon expression in E.coli. Does not have antitoxin activity on other toxins with the LXG toxin domain
 
   
 0.957
rtbD
Ribonuclease toxin of the rtbd-rtbe toxin-antitoxin system; Toxic component of a type II toxin-antitoxin (TA) system. The C-terminus (residues 409-569) has RNase activity, and inhibits growth upon expression in E.coli. In vitro RNase activity and in vivo growth inhibition are neutralized by cognate antitoxin YxxD, but not by antitoxins specific to other toxins with the LXG domain
 
    
 0.907
rttO
Putative ribonuclease antitoxin; Probable antitoxin component of a type II toxin-antitoxin (TA) system. Probably neutralizes the ability to inhibit growth of cognate toxin YwqJ. Probably does not have antitoxin activity on other toxins with the LXG toxin domain (By similarity)
     
 0.884
rttF
Antitoxin factor of ribonuclease toxin rttg; Antitoxin component of a type II toxin-antitoxin (TA) system. Neutralizes the RNase activity of cognate toxin YqcG, as well as its ability to inhibit growth upon expression in E.coli. Does not have antitoxin activity on other toxins with the LXG toxin domain
     
 0.850
rtbE
Antitoxin factor of the rttd-rtte toxin-antitoxin system; Antitoxin component of a type II toxin-antitoxin (TA) system. Neutralizes the RNase activity of cognate toxin YxiD, as well as its ability to inhibit growth upon expression in E.coli. Does not have antitoxin activity on other toxins with the LXG toxin domain
 
   
 0.821
yabD
Tatd dnase family protein; Uncharacterized metal-dependent hydrolase YabD; Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme
      
 0.781
bacA
Bacilysin biosynthesis protein, dehydratase; Part of the bacABCDEF operon responsible for the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin. Bacilysin is an irreversible inactivator of the glutaminase domain of glucosamine synthetase . BacA is an unusual prephenate decarboxylase that avoids the typical aromatization of the cyclohexadienol ring of prephenate . BacA catalyzes the protonation of prephenate (1-carboxy-4-hydroxy- alpha-oxo-2,5-cyclohexadiene-1-propanoic acid) at C6 position, followed by a decarboxylatio [...]
  
     0.778
spsD
Spore coat polysaccharide biosynthesis protein SpsD; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme
  
     0.765
spsB
Putative dtdp glycosyl/glycerophosphate transferase; Spore coat polysaccharide biosynthesis protein SpsB; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme
  
     0.754
Your Current Organism:
Bacillus subtilis
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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