node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
comA | phrF | BSU31680 | BSU37470 | Two-component response regulator; Response regulator in the two-component regulatory system ComP/ComA involved in a major quorum response pathway that regulates the development of genetic competence. Regulates directly the expression of over 20 genes, including genes of the srfA operon, degQ, rapA, rapC, rapE, rapF, etc. Regulates indirectly, through the regulation of comK transcription, the expression of late competence genes. | Secreted regulator of the activity of phosphatase RapF; Inhibitor of the activity of phosphatase RapF; Belongs to the phr family. | 0.483 |
comA | rapH | BSU31680 | BSU06830 | Two-component response regulator; Response regulator in the two-component regulatory system ComP/ComA involved in a major quorum response pathway that regulates the development of genetic competence. Regulates directly the expression of over 20 genes, including genes of the srfA operon, degQ, rapA, rapC, rapE, rapF, etc. Regulates indirectly, through the regulation of comK transcription, the expression of late competence genes. | Response regulator aspartate phosphatase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the RAP family. | 0.903 |
comA | srfAA | BSU31680 | BSU03480 | Two-component response regulator; Response regulator in the two-component regulatory system ComP/ComA involved in a major quorum response pathway that regulates the development of genetic competence. Regulates directly the expression of over 20 genes, including genes of the srfA operon, degQ, rapA, rapC, rapE, rapF, etc. Regulates indirectly, through the regulation of comK transcription, the expression of late competence genes. | Surfactin synthetase; This protein is a multifunctional enzyme able to activate and polymerize the amino acids Leu, Glu, Asp and Val. Activation sites for these AA consist of individual domains. | 0.432 |
degU | rapH | BSU35490 | BSU06830 | Two-component response regulator; Member of the two-component regulatory system DegS/DegU, which plays an important role in the transition growth phase. Involved in the control of expression of different cellular functions, including production of degradative enzymes such as the neutral and alkaline proteases, flagellum formation, biofilm formation, and competence for DNA uptake. Positively or negatively regulates expression of many different genes. The phosphorylated form is required for synthesis of degradative enzymes, flagellum formation and biofilm formation. The unphosphorylated [...] | Response regulator aspartate phosphatase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the RAP family. | 0.901 |
degU | rghRA | BSU35490 | BSU33660 | Two-component response regulator; Member of the two-component regulatory system DegS/DegU, which plays an important role in the transition growth phase. Involved in the control of expression of different cellular functions, including production of degradative enzymes such as the neutral and alkaline proteases, flagellum formation, biofilm formation, and competence for DNA uptake. Positively or negatively regulates expression of many different genes. The phosphorylated form is required for synthesis of degradative enzymes, flagellum formation and biofilm formation. The unphosphorylated [...] | Transcriptional repressor; Represses the expression of yvaM and both rapG and rapH. Binds directly to the promoter regions of yvaM, rapG and rapH. | 0.489 |
phrA | phrC | BSU12440 | BSU03780 | Secreted inhibitor of the activity of phosphatase RapA; Inhibitor of the activity of phosphatase RapA. | Phosphatase RapC inhibitor; Inhibitor of the activity of phosphatase RapC; Belongs to the phr family. | 0.917 |
phrA | phrF | BSU12440 | BSU37470 | Secreted inhibitor of the activity of phosphatase RapA; Inhibitor of the activity of phosphatase RapA. | Secreted regulator of the activity of phosphatase RapF; Inhibitor of the activity of phosphatase RapF; Belongs to the phr family. | 0.776 |
phrA | phrH | BSU12440 | BSU06839 | Secreted inhibitor of the activity of phosphatase RapA; Inhibitor of the activity of phosphatase RapA. | Hexapeptide inhibitor of regulatory cascade; Inhibitor of the activity of phosphatase RapH. May inhibit the rapH promoter after import into the cytoplasm. | 0.825 |
phrA | phrI | BSU12440 | BSU05020 | Secreted inhibitor of the activity of phosphatase RapA; Inhibitor of the activity of phosphatase RapA. | Secreted regulator of the activity of phosphatase RapI; Inhibitor of the activity of phosphatase RapI. | 0.680 |
phrA | rapH | BSU12440 | BSU06830 | Secreted inhibitor of the activity of phosphatase RapA; Inhibitor of the activity of phosphatase RapA. | Response regulator aspartate phosphatase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the RAP family. | 0.580 |
phrA | spo0F | BSU12440 | BSU37130 | Secreted inhibitor of the activity of phosphatase RapA; Inhibitor of the activity of phosphatase RapA. | Two-component response regulator; Key element in the phosphorelay regulating sporulation initiation. Phosphorylation of spo0B during sporulation initiation. | 0.921 |
phrC | phrA | BSU03780 | BSU12440 | Phosphatase RapC inhibitor; Inhibitor of the activity of phosphatase RapC; Belongs to the phr family. | Secreted inhibitor of the activity of phosphatase RapA; Inhibitor of the activity of phosphatase RapA. | 0.917 |
phrC | phrF | BSU03780 | BSU37470 | Phosphatase RapC inhibitor; Inhibitor of the activity of phosphatase RapC; Belongs to the phr family. | Secreted regulator of the activity of phosphatase RapF; Inhibitor of the activity of phosphatase RapF; Belongs to the phr family. | 0.941 |
phrC | phrH | BSU03780 | BSU06839 | Phosphatase RapC inhibitor; Inhibitor of the activity of phosphatase RapC; Belongs to the phr family. | Hexapeptide inhibitor of regulatory cascade; Inhibitor of the activity of phosphatase RapH. May inhibit the rapH promoter after import into the cytoplasm. | 0.630 |
phrC | phrI | BSU03780 | BSU05020 | Phosphatase RapC inhibitor; Inhibitor of the activity of phosphatase RapC; Belongs to the phr family. | Secreted regulator of the activity of phosphatase RapI; Inhibitor of the activity of phosphatase RapI. | 0.581 |
phrC | rapH | BSU03780 | BSU06830 | Phosphatase RapC inhibitor; Inhibitor of the activity of phosphatase RapC; Belongs to the phr family. | Response regulator aspartate phosphatase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the RAP family. | 0.746 |
phrC | spo0F | BSU03780 | BSU37130 | Phosphatase RapC inhibitor; Inhibitor of the activity of phosphatase RapC; Belongs to the phr family. | Two-component response regulator; Key element in the phosphorelay regulating sporulation initiation. Phosphorylation of spo0B during sporulation initiation. | 0.712 |
phrC | srfAA | BSU03780 | BSU03480 | Phosphatase RapC inhibitor; Inhibitor of the activity of phosphatase RapC; Belongs to the phr family. | Surfactin synthetase; This protein is a multifunctional enzyme able to activate and polymerize the amino acids Leu, Glu, Asp and Val. Activation sites for these AA consist of individual domains. | 0.840 |
phrF | comA | BSU37470 | BSU31680 | Secreted regulator of the activity of phosphatase RapF; Inhibitor of the activity of phosphatase RapF; Belongs to the phr family. | Two-component response regulator; Response regulator in the two-component regulatory system ComP/ComA involved in a major quorum response pathway that regulates the development of genetic competence. Regulates directly the expression of over 20 genes, including genes of the srfA operon, degQ, rapA, rapC, rapE, rapF, etc. Regulates indirectly, through the regulation of comK transcription, the expression of late competence genes. | 0.483 |
phrF | phrA | BSU37470 | BSU12440 | Secreted regulator of the activity of phosphatase RapF; Inhibitor of the activity of phosphatase RapF; Belongs to the phr family. | Secreted inhibitor of the activity of phosphatase RapA; Inhibitor of the activity of phosphatase RapA. | 0.776 |