STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yfmOMetal efflux transporter; Acts to efflux copper or a copper complex. It is possible that YfmO could contribute to copper resistance. Belongs to the major facilitator superfamily. (396 aa)    
Predicted Functional Partners:
yyaN
Putative transcriptional regulator (MerR family); Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator.
      
 0.919
yfmP
Transcriptional regulator (MerR family) of metal efflux transporter expression; Repressor of the yfmOP operon. A mutation in yfmP leads to overexpression of yfmO, probably causing a decrease in cellular copper that is eventually responsible for a reduced copper induction of copZA.
  
  
 0.884
yxaD
Putative transcriptional regulator (MarR family); Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr: putative regulator.
 
    0.757
cueR
Copper efflux transcriptional regulator; Transcriptional activator of the copZA operon.
 
   
 0.573
yraB
Putative transcriptional regulator (MerR family); Transcriptional regulator involved in the response to aldehyde stress. Binds to the promoter region of the adhA-yraA operon, the yraC and its own promoter region; binding is unchanged in the presence of aldehydes.
      
 0.573
czrA
Transcriptional regulator (multiple metal-sensing ArsR-SmtB transcriptional repressors family); Metal-responsive transcriptional regulator that represses transcription of cadA and the czcD-trkA operon by binding specifically to their promoter. Binding of zinc causes the repressor to dissociate from the DNA.
      
 0.485
ycnI
Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function.
  
     0.430
yoaK
Putative membrane protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm: putative membrane component.
  
    0.426
copZ
Copper insertion chaperone and transporter component; Chaperone that serves for the intracellular sequestration and transport of Cu(+). Delivers Cu(+) to the copper-transporting ATPase CopA. Functions in E.coli to transfer Cu(+) to CopA missing its first metal-binding domain.
      
 0.424
yvaC
Putative integral inner membrane protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm: putative membrane component.
  
    0.423
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
Server load: low (26%) [HD]