| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| copZ | cueR | BSU33510 | BSU09560 | Copper insertion chaperone and transporter component; Chaperone that serves for the intracellular sequestration and transport of Cu(+). Delivers Cu(+) to the copper-transporting ATPase CopA. Functions in E.coli to transfer Cu(+) to CopA missing its first metal-binding domain. | Copper efflux transcriptional regulator; Transcriptional activator of the copZA operon. | 0.919 |
| copZ | ycnI | BSU33510 | BSU03940 | Copper insertion chaperone and transporter component; Chaperone that serves for the intracellular sequestration and transport of Cu(+). Delivers Cu(+) to the copper-transporting ATPase CopA. Functions in E.coli to transfer Cu(+) to CopA missing its first metal-binding domain. | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. | 0.788 |
| copZ | yfmO | BSU33510 | BSU07400 | Copper insertion chaperone and transporter component; Chaperone that serves for the intracellular sequestration and transport of Cu(+). Delivers Cu(+) to the copper-transporting ATPase CopA. Functions in E.coli to transfer Cu(+) to CopA missing its first metal-binding domain. | Metal efflux transporter; Acts to efflux copper or a copper complex. It is possible that YfmO could contribute to copper resistance. Belongs to the major facilitator superfamily. | 0.454 |
| copZ | yfmP | BSU33510 | BSU07390 | Copper insertion chaperone and transporter component; Chaperone that serves for the intracellular sequestration and transport of Cu(+). Delivers Cu(+) to the copper-transporting ATPase CopA. Functions in E.coli to transfer Cu(+) to CopA missing its first metal-binding domain. | Transcriptional regulator (MerR family) of metal efflux transporter expression; Repressor of the yfmOP operon. A mutation in yfmP leads to overexpression of yfmO, probably causing a decrease in cellular copper that is eventually responsible for a reduced copper induction of copZA. | 0.542 |
| copZ | yyaN | BSU33510 | BSU40800 | Copper insertion chaperone and transporter component; Chaperone that serves for the intracellular sequestration and transport of Cu(+). Delivers Cu(+) to the copper-transporting ATPase CopA. Functions in E.coli to transfer Cu(+) to CopA missing its first metal-binding domain. | Putative transcriptional regulator (MerR family); Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. | 0.623 |
| cueR | copZ | BSU09560 | BSU33510 | Copper efflux transcriptional regulator; Transcriptional activator of the copZA operon. | Copper insertion chaperone and transporter component; Chaperone that serves for the intracellular sequestration and transport of Cu(+). Delivers Cu(+) to the copper-transporting ATPase CopA. Functions in E.coli to transfer Cu(+) to CopA missing its first metal-binding domain. | 0.919 |
| cueR | yfmO | BSU09560 | BSU07400 | Copper efflux transcriptional regulator; Transcriptional activator of the copZA operon. | Metal efflux transporter; Acts to efflux copper or a copper complex. It is possible that YfmO could contribute to copper resistance. Belongs to the major facilitator superfamily. | 0.579 |
| cueR | yfmP | BSU09560 | BSU07390 | Copper efflux transcriptional regulator; Transcriptional activator of the copZA operon. | Transcriptional regulator (MerR family) of metal efflux transporter expression; Repressor of the yfmOP operon. A mutation in yfmP leads to overexpression of yfmO, probably causing a decrease in cellular copper that is eventually responsible for a reduced copper induction of copZA. | 0.619 |
| cueR | yyaN | BSU09560 | BSU40800 | Copper efflux transcriptional regulator; Transcriptional activator of the copZA operon. | Putative transcriptional regulator (MerR family); Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. | 0.831 |
| ycnI | copZ | BSU03940 | BSU33510 | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. | Copper insertion chaperone and transporter component; Chaperone that serves for the intracellular sequestration and transport of Cu(+). Delivers Cu(+) to the copper-transporting ATPase CopA. Functions in E.coli to transfer Cu(+) to CopA missing its first metal-binding domain. | 0.788 |
| ycnI | yfmO | BSU03940 | BSU07400 | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. | Metal efflux transporter; Acts to efflux copper or a copper complex. It is possible that YfmO could contribute to copper resistance. Belongs to the major facilitator superfamily. | 0.430 |
| ycnI | yoaK | BSU03940 | BSU18640 | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. | Putative membrane protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm: putative membrane component. | 0.492 |
| yfmN | yfmO | BSU07410 | BSU07400 | Hypothetical protein; Evidence 5: No homology to any previously reported sequences. | Metal efflux transporter; Acts to efflux copper or a copper complex. It is possible that YfmO could contribute to copper resistance. Belongs to the major facilitator superfamily. | 0.426 |
| yfmO | copZ | BSU07400 | BSU33510 | Metal efflux transporter; Acts to efflux copper or a copper complex. It is possible that YfmO could contribute to copper resistance. Belongs to the major facilitator superfamily. | Copper insertion chaperone and transporter component; Chaperone that serves for the intracellular sequestration and transport of Cu(+). Delivers Cu(+) to the copper-transporting ATPase CopA. Functions in E.coli to transfer Cu(+) to CopA missing its first metal-binding domain. | 0.454 |
| yfmO | cueR | BSU07400 | BSU09560 | Metal efflux transporter; Acts to efflux copper or a copper complex. It is possible that YfmO could contribute to copper resistance. Belongs to the major facilitator superfamily. | Copper efflux transcriptional regulator; Transcriptional activator of the copZA operon. | 0.579 |
| yfmO | ycnI | BSU07400 | BSU03940 | Metal efflux transporter; Acts to efflux copper or a copper complex. It is possible that YfmO could contribute to copper resistance. Belongs to the major facilitator superfamily. | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. | 0.430 |
| yfmO | yfmN | BSU07400 | BSU07410 | Metal efflux transporter; Acts to efflux copper or a copper complex. It is possible that YfmO could contribute to copper resistance. Belongs to the major facilitator superfamily. | Hypothetical protein; Evidence 5: No homology to any previously reported sequences. | 0.426 |
| yfmO | yfmP | BSU07400 | BSU07390 | Metal efflux transporter; Acts to efflux copper or a copper complex. It is possible that YfmO could contribute to copper resistance. Belongs to the major facilitator superfamily. | Transcriptional regulator (MerR family) of metal efflux transporter expression; Repressor of the yfmOP operon. A mutation in yfmP leads to overexpression of yfmO, probably causing a decrease in cellular copper that is eventually responsible for a reduced copper induction of copZA. | 0.970 |
| yfmO | yoaK | BSU07400 | BSU18640 | Metal efflux transporter; Acts to efflux copper or a copper complex. It is possible that YfmO could contribute to copper resistance. Belongs to the major facilitator superfamily. | Putative membrane protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm: putative membrane component. | 0.429 |
| yfmO | yraB | BSU07400 | BSU27000 | Metal efflux transporter; Acts to efflux copper or a copper complex. It is possible that YfmO could contribute to copper resistance. Belongs to the major facilitator superfamily. | Putative transcriptional regulator (MerR family); Transcriptional regulator involved in the response to aldehyde stress. Binds to the promoter region of the adhA-yraA operon, the yraC and its own promoter region; binding is unchanged in the presence of aldehydes. | 0.633 |
