node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cimH | citH | BSU38770 | BSU39060 | citrate/malate/H+ symporter; Proton motive force-driven secondary transporter that catalyzes the uptake of both citrate and malate. Appears to be an electroneutral proton-solute symporter; the number of protons transported is equal to the valence of the transported anions. Is strictly stereoselective, translocating only the (S)-enantiomer of malate. | Secondary transporter of divalent metal ions/citrate complexes; Transports the free citrate anion. Probably cotransports citrate and at least three or four protons. The citrate uptake is inhibited by the presence of magnesium ions; Belongs to the CitM (TC 2.A.11) transporter family. | 0.681 |
cimH | citS | BSU38770 | BSU07580 | citrate/malate/H+ symporter; Proton motive force-driven secondary transporter that catalyzes the uptake of both citrate and malate. Appears to be an electroneutral proton-solute symporter; the number of protons transported is equal to the valence of the transported anions. Is strictly stereoselective, translocating only the (S)-enantiomer of malate. | Two-component sensor histidine kinase; Member of the two-component regulatory system CitT/CitS. Regulates the expression of the citM-yflN operon. Functions probably as a membrane-associated protein kinase that phosphorylates CitT in response to environmental citrate or Mg(2+)-citrate complex. | 0.897 |
cimH | citT | BSU38770 | BSU07590 | citrate/malate/H+ symporter; Proton motive force-driven secondary transporter that catalyzes the uptake of both citrate and malate. Appears to be an electroneutral proton-solute symporter; the number of protons transported is equal to the valence of the transported anions. Is strictly stereoselective, translocating only the (S)-enantiomer of malate. | Two-component response regulator; Member of the two-component regulatory system CitT/CitS. Regulates the expression of the citM-yflN operon. Phosphorylated CitT binds to the citM promoter to activate the transcription of the citM- yflN operon. | 0.714 |
cimH | dctR | BSU38770 | BSU04460 | citrate/malate/H+ symporter; Proton motive force-driven secondary transporter that catalyzes the uptake of both citrate and malate. Appears to be an electroneutral proton-solute symporter; the number of protons transported is equal to the valence of the transported anions. Is strictly stereoselective, translocating only the (S)-enantiomer of malate. | Two-component response regulator; Member of the two-component regulatory system DctS/DctR. Essential for expression of dctP. | 0.465 |
cimH | yflS | BSU38770 | BSU07570 | citrate/malate/H+ symporter; Proton motive force-driven secondary transporter that catalyzes the uptake of both citrate and malate. Appears to be an electroneutral proton-solute symporter; the number of protons transported is equal to the valence of the transported anions. Is strictly stereoselective, translocating only the (S)-enantiomer of malate. | 2-oxoglutarate/malate transporter; Might be a malate transporter. | 0.506 |
cimH | yufM | BSU38770 | BSU31530 | citrate/malate/H+ symporter; Proton motive force-driven secondary transporter that catalyzes the uptake of both citrate and malate. Appears to be an electroneutral proton-solute symporter; the number of protons transported is equal to the valence of the transported anions. Is strictly stereoselective, translocating only the (S)-enantiomer of malate. | Two-component response regulator [YufL]; Member of a two-component regulatory system MalK/MalR. Activates transcription of maeA, maeN and yflS in presence of malate by binding to their promoter region. | 0.695 |
citH | cimH | BSU39060 | BSU38770 | Secondary transporter of divalent metal ions/citrate complexes; Transports the free citrate anion. Probably cotransports citrate and at least three or four protons. The citrate uptake is inhibited by the presence of magnesium ions; Belongs to the CitM (TC 2.A.11) transporter family. | citrate/malate/H+ symporter; Proton motive force-driven secondary transporter that catalyzes the uptake of both citrate and malate. Appears to be an electroneutral proton-solute symporter; the number of protons transported is equal to the valence of the transported anions. Is strictly stereoselective, translocating only the (S)-enantiomer of malate. | 0.681 |
citH | citS | BSU39060 | BSU07580 | Secondary transporter of divalent metal ions/citrate complexes; Transports the free citrate anion. Probably cotransports citrate and at least three or four protons. The citrate uptake is inhibited by the presence of magnesium ions; Belongs to the CitM (TC 2.A.11) transporter family. | Two-component sensor histidine kinase; Member of the two-component regulatory system CitT/CitS. Regulates the expression of the citM-yflN operon. Functions probably as a membrane-associated protein kinase that phosphorylates CitT in response to environmental citrate or Mg(2+)-citrate complex. | 0.849 |
citH | citT | BSU39060 | BSU07590 | Secondary transporter of divalent metal ions/citrate complexes; Transports the free citrate anion. Probably cotransports citrate and at least three or four protons. The citrate uptake is inhibited by the presence of magnesium ions; Belongs to the CitM (TC 2.A.11) transporter family. | Two-component response regulator; Member of the two-component regulatory system CitT/CitS. Regulates the expression of the citM-yflN operon. Phosphorylated CitT binds to the citM promoter to activate the transcription of the citM- yflN operon. | 0.507 |
citS | cimH | BSU07580 | BSU38770 | Two-component sensor histidine kinase; Member of the two-component regulatory system CitT/CitS. Regulates the expression of the citM-yflN operon. Functions probably as a membrane-associated protein kinase that phosphorylates CitT in response to environmental citrate or Mg(2+)-citrate complex. | citrate/malate/H+ symporter; Proton motive force-driven secondary transporter that catalyzes the uptake of both citrate and malate. Appears to be an electroneutral proton-solute symporter; the number of protons transported is equal to the valence of the transported anions. Is strictly stereoselective, translocating only the (S)-enantiomer of malate. | 0.897 |
citS | citH | BSU07580 | BSU39060 | Two-component sensor histidine kinase; Member of the two-component regulatory system CitT/CitS. Regulates the expression of the citM-yflN operon. Functions probably as a membrane-associated protein kinase that phosphorylates CitT in response to environmental citrate or Mg(2+)-citrate complex. | Secondary transporter of divalent metal ions/citrate complexes; Transports the free citrate anion. Probably cotransports citrate and at least three or four protons. The citrate uptake is inhibited by the presence of magnesium ions; Belongs to the CitM (TC 2.A.11) transporter family. | 0.849 |
citS | citT | BSU07580 | BSU07590 | Two-component sensor histidine kinase; Member of the two-component regulatory system CitT/CitS. Regulates the expression of the citM-yflN operon. Functions probably as a membrane-associated protein kinase that phosphorylates CitT in response to environmental citrate or Mg(2+)-citrate complex. | Two-component response regulator; Member of the two-component regulatory system CitT/CitS. Regulates the expression of the citM-yflN operon. Phosphorylated CitT binds to the citM promoter to activate the transcription of the citM- yflN operon. | 0.999 |
citS | dctR | BSU07580 | BSU04460 | Two-component sensor histidine kinase; Member of the two-component regulatory system CitT/CitS. Regulates the expression of the citM-yflN operon. Functions probably as a membrane-associated protein kinase that phosphorylates CitT in response to environmental citrate or Mg(2+)-citrate complex. | Two-component response regulator; Member of the two-component regulatory system DctS/DctR. Essential for expression of dctP. | 0.864 |
citS | ydhC | BSU07580 | BSU05700 | Two-component sensor histidine kinase; Member of the two-component regulatory system CitT/CitS. Regulates the expression of the citM-yflN operon. Functions probably as a membrane-associated protein kinase that phosphorylates CitT in response to environmental citrate or Mg(2+)-citrate complex. | Putative transcriptional regulator (GntR family); Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr: putative regulator. | 0.754 |
citS | yflN | BSU07580 | BSU07620 | Two-component sensor histidine kinase; Member of the two-component regulatory system CitT/CitS. Regulates the expression of the citM-yflN operon. Functions probably as a membrane-associated protein kinase that phosphorylates CitT in response to environmental citrate or Mg(2+)-citrate complex. | Putative metal-dependent hydrolase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the metallo-beta-lactamase superfamily. | 0.788 |
citS | yflP | BSU07580 | BSU07600 | Two-component sensor histidine kinase; Member of the two-component regulatory system CitT/CitS. Regulates the expression of the citM-yflN operon. Functions probably as a membrane-associated protein kinase that phosphorylates CitT in response to environmental citrate or Mg(2+)-citrate complex. | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; Belongs to the UPF0065 (bug) family. | 0.977 |
citS | yflS | BSU07580 | BSU07570 | Two-component sensor histidine kinase; Member of the two-component regulatory system CitT/CitS. Regulates the expression of the citM-yflN operon. Functions probably as a membrane-associated protein kinase that phosphorylates CitT in response to environmental citrate or Mg(2+)-citrate complex. | 2-oxoglutarate/malate transporter; Might be a malate transporter. | 0.902 |
citS | yufM | BSU07580 | BSU31530 | Two-component sensor histidine kinase; Member of the two-component regulatory system CitT/CitS. Regulates the expression of the citM-yflN operon. Functions probably as a membrane-associated protein kinase that phosphorylates CitT in response to environmental citrate or Mg(2+)-citrate complex. | Two-component response regulator [YufL]; Member of a two-component regulatory system MalK/MalR. Activates transcription of maeA, maeN and yflS in presence of malate by binding to their promoter region. | 0.864 |
citS | ywhA | BSU07580 | BSU37550 | Two-component sensor histidine kinase; Member of the two-component regulatory system CitT/CitS. Regulates the expression of the citM-yflN operon. Functions probably as a membrane-associated protein kinase that phosphorylates CitT in response to environmental citrate or Mg(2+)-citrate complex. | Putative transcriptional regulator (MarR family); Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr: putative regulator. | 0.753 |
citT | cimH | BSU07590 | BSU38770 | Two-component response regulator; Member of the two-component regulatory system CitT/CitS. Regulates the expression of the citM-yflN operon. Phosphorylated CitT binds to the citM promoter to activate the transcription of the citM- yflN operon. | citrate/malate/H+ symporter; Proton motive force-driven secondary transporter that catalyzes the uptake of both citrate and malate. Appears to be an electroneutral proton-solute symporter; the number of protons transported is equal to the valence of the transported anions. Is strictly stereoselective, translocating only the (S)-enantiomer of malate. | 0.714 |