Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
nfsBNAD(P)H-flavin oxidoreductase (nitroreductase); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the nitroreductase family. (221 aa)    
Predicted Functional Partners:
ywrO
Nitroreductase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme.
  
  
 0.817
yorD
Hypothetical protein; Evidence 5: No homology to any previously reported sequences.
      
 0.749
pnbA
Para-nitrobenzyl esterase (intracellular esterase B); Catalyzes hydrolysis of several beta-lactam antibiotic PNB esters to the corresponding free acid and PNB alcohol; Belongs to the type-B carboxylesterase/lipase family.
      
 0.718
treR
Transcriptional regulator (GntR family); Repressor for the trePA operon. It is able to bind trehalose- 6-phosphate.
 
  
 0.714
nfrAB
NADPH-FMN oxidoreductase (nitroreductase); Reduces FMNH(2) to FMN, with NADH or NADPH as reductant. It also reduces nitroaromatic compounds, quinones, chromates and azo dyes. It could supply the reduced form of FMN to luciferase-like protein and contribute to the degradation of aromatic compounds. Belongs to the flavin oxidoreductase frp family.
   
  
 0.670
nfrAA
FMN-containing NADPH-linked nitro/flavin reductase; Reduces FMNH(2) to FMN, with NADPH as reductant. It also reduces nitroaromatic compounds, quinones and azo dyes.
   
  
 0.642
yfmJ
Putative oxidoreductase; Putative quinone oxidoreductase that may contribute to the degradation of aromatic compounds; Belongs to the NADP-dependent oxidoreductase L4BD family.
      
 0.633
treA
Trehalose-6-phosphate hydrolase; Hydrolyzes trehalose-6-phosphate to glucose and glucose 6- phosphate. Can also very effectively hydrolyzes p-nitrophenyl-alpha-D- glucopyranoside, but not lactose, maltose, sucrose or sucrose-6- phosphate. Trehalose is also hydrolyzed, but to a much smaller extent than trehalose-6-phosphate; Belongs to the glycosyl hydrolase 13 family.
  
  
 0.585
yybR
Putative transcriptional regulator; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr: putative regulator.
     
 0.556
birA
Biotin acetyl-CoA-carboxylase ligase and biotin regulon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.
  
    0.534
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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