node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
estB | yfiJ | BSU08350 | BSU08290 | Secreted esterase / lipase; An esterase which preferentially hydrolyzes triacylglyceride substrates with short chain fatty acids (less than C10) with the maximum activity towards tricaprylin (C8:0). Active against p- nitrophenylesters with fatty acid chain lengths from C6 to C18. | Two-component sensor histidine kinase [YfiK]; Required for resistance to linearmycins, a family of antibiotic-specialized metabolites produced by some streptomycetes. Member of the two-component regulatory system LnrJ/LnrK, which induces expression of the LnrLMN ABC transporter in response to linearmycins and other polyenes. Acts as a specific sensor for linearmycin, either directly through binding or indirectly through membrane perturbation. Probably activates LnrK by phosphorylation. May also promote biofilm formation. | 0.729 |
estB | yfiK | BSU08350 | BSU08300 | Secreted esterase / lipase; An esterase which preferentially hydrolyzes triacylglyceride substrates with short chain fatty acids (less than C10) with the maximum activity towards tricaprylin (C8:0). Active against p- nitrophenylesters with fatty acid chain lengths from C6 to C18. | Two-component response regulator [YfiJ]; Required for resistance to linearmycins, a family of antibiotic-specialized metabolites produced by some streptomycetes. Member of the two-component regulatory system LnrJ/LnrK, which induces expression of the LnrLMN ABC transporter in response to linearmycins and other polyenes. Probably binds to the promoter region of the lnrLMN operon and directly regulates its expression (Probable). May also promote biofilm formation. | 0.589 |
estB | yfiL | BSU08350 | BSU08310 | Secreted esterase / lipase; An esterase which preferentially hydrolyzes triacylglyceride substrates with short chain fatty acids (less than C10) with the maximum activity towards tricaprylin (C8:0). Active against p- nitrophenylesters with fatty acid chain lengths from C6 to C18. | Putative ABC transporter (ATP-binding protein); Required for resistance to linearmycins, a family of antibiotic-specialized metabolites produced by some streptomycetes. Part of the ABC transporter complex LnrLMN that probably facilitates linearmycin removal from the membrane. Responsible for energy coupling to the transport system. Also mediates KinC-dependent biofilm morphology. | 0.482 |
estB | yfiM | BSU08350 | BSU08320 | Secreted esterase / lipase; An esterase which preferentially hydrolyzes triacylglyceride substrates with short chain fatty acids (less than C10) with the maximum activity towards tricaprylin (C8:0). Active against p- nitrophenylesters with fatty acid chain lengths from C6 to C18. | Putative ABC transporter (permease); Required for resistance to linearmycins, a family of antibiotic-specialized metabolites produced by some streptomycetes. Part of the ABC transporter complex LnrLMN that probably facilitates linearmycin removal from the membrane. Responsible for the translocation of the substrate across the membrane. Also mediates KinC-dependent biofilm morphology ; Belongs to the ABC-2 integral membrane protein family. | 0.698 |
estB | yfiN | BSU08350 | BSU08330 | Secreted esterase / lipase; An esterase which preferentially hydrolyzes triacylglyceride substrates with short chain fatty acids (less than C10) with the maximum activity towards tricaprylin (C8:0). Active against p- nitrophenylesters with fatty acid chain lengths from C6 to C18. | Putative ABC transporter (permease); Required for resistance to linearmycins, a family of antibiotic-specialized metabolites produced by some streptomycetes. Part of the ABC transporter complex LnrLMN that probably facilitates linearmycin removal from the membrane. Responsible for the translocation of the substrate across the membrane. Also mediates KinC-dependent biofilm morphology ; Belongs to the ABC-2 integral membrane protein family. | 0.561 |
nfrAB | ydgI | BSU03860 | BSU05660 | NADPH-FMN oxidoreductase (nitroreductase); Reduces FMNH(2) to FMN, with NADH or NADPH as reductant. It also reduces nitroaromatic compounds, quinones, chromates and azo dyes. It could supply the reduced form of FMN to luciferase-like protein and contribute to the degradation of aromatic compounds. Belongs to the flavin oxidoreductase frp family. | Putative dehydrogenase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. | 0.418 |
nfrAB | yfiM | BSU03860 | BSU08320 | NADPH-FMN oxidoreductase (nitroreductase); Reduces FMNH(2) to FMN, with NADH or NADPH as reductant. It also reduces nitroaromatic compounds, quinones, chromates and azo dyes. It could supply the reduced form of FMN to luciferase-like protein and contribute to the degradation of aromatic compounds. Belongs to the flavin oxidoreductase frp family. | Putative ABC transporter (permease); Required for resistance to linearmycins, a family of antibiotic-specialized metabolites produced by some streptomycetes. Part of the ABC transporter complex LnrLMN that probably facilitates linearmycin removal from the membrane. Responsible for the translocation of the substrate across the membrane. Also mediates KinC-dependent biofilm morphology ; Belongs to the ABC-2 integral membrane protein family. | 0.471 |
nfrAB | yfiN | BSU03860 | BSU08330 | NADPH-FMN oxidoreductase (nitroreductase); Reduces FMNH(2) to FMN, with NADH or NADPH as reductant. It also reduces nitroaromatic compounds, quinones, chromates and azo dyes. It could supply the reduced form of FMN to luciferase-like protein and contribute to the degradation of aromatic compounds. Belongs to the flavin oxidoreductase frp family. | Putative ABC transporter (permease); Required for resistance to linearmycins, a family of antibiotic-specialized metabolites produced by some streptomycetes. Part of the ABC transporter complex LnrLMN that probably facilitates linearmycin removal from the membrane. Responsible for the translocation of the substrate across the membrane. Also mediates KinC-dependent biofilm morphology ; Belongs to the ABC-2 integral membrane protein family. | 0.485 |
nfrAB | yvfS | BSU03860 | BSU34080 | NADPH-FMN oxidoreductase (nitroreductase); Reduces FMNH(2) to FMN, with NADH or NADPH as reductant. It also reduces nitroaromatic compounds, quinones, chromates and azo dyes. It could supply the reduced form of FMN to luciferase-like protein and contribute to the degradation of aromatic compounds. Belongs to the flavin oxidoreductase frp family. | Putative ABC transporter (permease); Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. | 0.485 |
sspE | yfiJ | BSU08660 | BSU08290 | Small acid-soluble spore protein (gamma-type SASP); SASP are proteins degraded in the first minutes of spore germination and provide amino acids for both new protein synthesis and metabolism. These proteins may be involved in dormant spore's high resistance to UV light. | Two-component sensor histidine kinase [YfiK]; Required for resistance to linearmycins, a family of antibiotic-specialized metabolites produced by some streptomycetes. Member of the two-component regulatory system LnrJ/LnrK, which induces expression of the LnrLMN ABC transporter in response to linearmycins and other polyenes. Acts as a specific sensor for linearmycin, either directly through binding or indirectly through membrane perturbation. Probably activates LnrK by phosphorylation. May also promote biofilm formation. | 0.401 |
sspE | yfiK | BSU08660 | BSU08300 | Small acid-soluble spore protein (gamma-type SASP); SASP are proteins degraded in the first minutes of spore germination and provide amino acids for both new protein synthesis and metabolism. These proteins may be involved in dormant spore's high resistance to UV light. | Two-component response regulator [YfiJ]; Required for resistance to linearmycins, a family of antibiotic-specialized metabolites produced by some streptomycetes. Member of the two-component regulatory system LnrJ/LnrK, which induces expression of the LnrLMN ABC transporter in response to linearmycins and other polyenes. Probably binds to the promoter region of the lnrLMN operon and directly regulates its expression (Probable). May also promote biofilm formation. | 0.446 |
sspE | yfiM | BSU08660 | BSU08320 | Small acid-soluble spore protein (gamma-type SASP); SASP are proteins degraded in the first minutes of spore germination and provide amino acids for both new protein synthesis and metabolism. These proteins may be involved in dormant spore's high resistance to UV light. | Putative ABC transporter (permease); Required for resistance to linearmycins, a family of antibiotic-specialized metabolites produced by some streptomycetes. Part of the ABC transporter complex LnrLMN that probably facilitates linearmycin removal from the membrane. Responsible for the translocation of the substrate across the membrane. Also mediates KinC-dependent biofilm morphology ; Belongs to the ABC-2 integral membrane protein family. | 0.489 |
sspE | yfiN | BSU08660 | BSU08330 | Small acid-soluble spore protein (gamma-type SASP); SASP are proteins degraded in the first minutes of spore germination and provide amino acids for both new protein synthesis and metabolism. These proteins may be involved in dormant spore's high resistance to UV light. | Putative ABC transporter (permease); Required for resistance to linearmycins, a family of antibiotic-specialized metabolites produced by some streptomycetes. Part of the ABC transporter complex LnrLMN that probably facilitates linearmycin removal from the membrane. Responsible for the translocation of the substrate across the membrane. Also mediates KinC-dependent biofilm morphology ; Belongs to the ABC-2 integral membrane protein family. | 0.424 |
ydfN | yfiM | BSU05480 | BSU08320 | Putative oxidoreductase; Putative nitroreductase that may contribute to the degradation of aromatic compounds. | Putative ABC transporter (permease); Required for resistance to linearmycins, a family of antibiotic-specialized metabolites produced by some streptomycetes. Part of the ABC transporter complex LnrLMN that probably facilitates linearmycin removal from the membrane. Responsible for the translocation of the substrate across the membrane. Also mediates KinC-dependent biofilm morphology ; Belongs to the ABC-2 integral membrane protein family. | 0.471 |
ydfN | yfiN | BSU05480 | BSU08330 | Putative oxidoreductase; Putative nitroreductase that may contribute to the degradation of aromatic compounds. | Putative ABC transporter (permease); Required for resistance to linearmycins, a family of antibiotic-specialized metabolites produced by some streptomycetes. Part of the ABC transporter complex LnrLMN that probably facilitates linearmycin removal from the membrane. Responsible for the translocation of the substrate across the membrane. Also mediates KinC-dependent biofilm morphology ; Belongs to the ABC-2 integral membrane protein family. | 0.488 |
ydfN | yvfS | BSU05480 | BSU34080 | Putative oxidoreductase; Putative nitroreductase that may contribute to the degradation of aromatic compounds. | Putative ABC transporter (permease); Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. | 0.485 |
ydgI | nfrAB | BSU05660 | BSU03860 | Putative dehydrogenase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. | NADPH-FMN oxidoreductase (nitroreductase); Reduces FMNH(2) to FMN, with NADH or NADPH as reductant. It also reduces nitroaromatic compounds, quinones, chromates and azo dyes. It could supply the reduced form of FMN to luciferase-like protein and contribute to the degradation of aromatic compounds. Belongs to the flavin oxidoreductase frp family. | 0.418 |
ydgI | yfiM | BSU05660 | BSU08320 | Putative dehydrogenase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. | Putative ABC transporter (permease); Required for resistance to linearmycins, a family of antibiotic-specialized metabolites produced by some streptomycetes. Part of the ABC transporter complex LnrLMN that probably facilitates linearmycin removal from the membrane. Responsible for the translocation of the substrate across the membrane. Also mediates KinC-dependent biofilm morphology ; Belongs to the ABC-2 integral membrane protein family. | 0.471 |
ydgI | yfiN | BSU05660 | BSU08330 | Putative dehydrogenase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. | Putative ABC transporter (permease); Required for resistance to linearmycins, a family of antibiotic-specialized metabolites produced by some streptomycetes. Part of the ABC transporter complex LnrLMN that probably facilitates linearmycin removal from the membrane. Responsible for the translocation of the substrate across the membrane. Also mediates KinC-dependent biofilm morphology ; Belongs to the ABC-2 integral membrane protein family. | 0.488 |
ydgI | yvfS | BSU05660 | BSU34080 | Putative dehydrogenase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. | Putative ABC transporter (permease); Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. | 0.485 |