STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yfiMABC-2 type transport system permease protein; Required for resistance to linearmycins, a family of antibiotic-specialized metabolites produced by some streptomycetes . Part of the ABC transporter complex LnrLMN that probably facilitates linearmycin removal from the membrane. Responsible for the translocation of the substrate across the membrane . Also mediates KinC-dependent biofilm morphology (396 aa)    
Predicted Functional Partners:
yfiL
ABC-2 type transport system ATP-binding protein; Required for resistance to linearmycins, a family of antibiotic-specialized metabolites produced by some streptomycetes . Part of the ABC transporter complex LnrLMN that probably facilitates linearmycin removal from the membrane. Responsible for energy coupling to the transport system . Also mediates KinC-dependent biofilm morphology
 
 
 0.993
yfiJ
Two-component sensor histidine kinase [yfik]; Required for resistance to linearmycins, a family of antibiotic-specialized metabolites produced by some streptomycetes . Member of the two-component regulatory system LnrJ/LnrK, which induces expression of the LnrLMN ABC transporter in response to linearmycins and other polyenes . Acts as a specific sensor for linearmycin, either directly through binding or indirectly through membrane perturbation. Probably activates LnrK by phosphorylation . May also promote biofilm formation
 
   
 0.988
yfiK
Two-component system, narl family, response regulator; Required for resistance to linearmycins, a family of antibiotic-specialized metabolites produced by some streptomycetes . Member of the two-component regulatory system LnrJ/LnrK, which induces expression of the LnrLMN ABC transporter in response to linearmycins and other polyenes . Probably binds to the promoter region of the lnrLMN operon and directly regulates its expression (Probable). May also promote biofilm formation
 
   
 0.963
yfiN
ABC-2 type transport system permease protein; Required for resistance to linearmycins, a family of antibiotic-specialized metabolites produced by some streptomycetes . Part of the ABC transporter complex LnrLMN that probably facilitates linearmycin removal from the membrane. Responsible for the translocation of the substrate across the membrane . Also mediates KinC-dependent biofilm morphology
 
 
0.955
estB
Extracellular esterase estb; An esterase which preferentially hydrolyzes triacylglyceride substrates with short chain fatty acids (less than C10) with the maximum activity towards tricaprylin (C8:0). Active against p- nitrophenylesters with fatty acid chain lengths from C6 to C18
      
 0.881
ponA
Peptidoglycan glycosyltransferase (penicillin-binding proteins 1a and 1b); Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits)
  
  
 0.782
pksM
Polyketide synthase pksm; Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism
     
 0.757
pksJ
Polyketide synthase of type i; Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism
     
 0.745
sspE
Small acid-soluble spore protein e (minor gamma-type sasp); SASP are proteins degraded in the first minutes of spore germination and provide amino acids for both new protein synthesis and metabolism. These proteins may be involved in dormant spore's high resistance to UV light
      
 0.713
ydgH
Putative drug exporter of the rnd superfamily; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MmpL subfamily
     
 0.577
Your Current Organism:
Bacillus subtilis
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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