node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
estB | yfiJ | BSU08350 | BSU08290 | Extracellular esterase estb; An esterase which preferentially hydrolyzes triacylglyceride substrates with short chain fatty acids (less than C10) with the maximum activity towards tricaprylin (C8:0). Active against p- nitrophenylesters with fatty acid chain lengths from C6 to C18 | Two-component sensor histidine kinase [yfik]; Required for resistance to linearmycins, a family of antibiotic-specialized metabolites produced by some streptomycetes . Member of the two-component regulatory system LnrJ/LnrK, which induces expression of the LnrLMN ABC transporter in response to linearmycins and other polyenes . Acts as a specific sensor for linearmycin, either directly through binding or indirectly through membrane perturbation. Probably activates LnrK by phosphorylation . May also promote biofilm formation | 0.711 |
estB | yfiK | BSU08350 | BSU08300 | Extracellular esterase estb; An esterase which preferentially hydrolyzes triacylglyceride substrates with short chain fatty acids (less than C10) with the maximum activity towards tricaprylin (C8:0). Active against p- nitrophenylesters with fatty acid chain lengths from C6 to C18 | Two-component system, narl family, response regulator; Required for resistance to linearmycins, a family of antibiotic-specialized metabolites produced by some streptomycetes . Member of the two-component regulatory system LnrJ/LnrK, which induces expression of the LnrLMN ABC transporter in response to linearmycins and other polyenes . Probably binds to the promoter region of the lnrLMN operon and directly regulates its expression (Probable). May also promote biofilm formation | 0.727 |
estB | yfiL | BSU08350 | BSU08310 | Extracellular esterase estb; An esterase which preferentially hydrolyzes triacylglyceride substrates with short chain fatty acids (less than C10) with the maximum activity towards tricaprylin (C8:0). Active against p- nitrophenylesters with fatty acid chain lengths from C6 to C18 | ABC-2 type transport system ATP-binding protein; Required for resistance to linearmycins, a family of antibiotic-specialized metabolites produced by some streptomycetes . Part of the ABC transporter complex LnrLMN that probably facilitates linearmycin removal from the membrane. Responsible for energy coupling to the transport system . Also mediates KinC-dependent biofilm morphology | 0.652 |
estB | yfiM | BSU08350 | BSU08320 | Extracellular esterase estb; An esterase which preferentially hydrolyzes triacylglyceride substrates with short chain fatty acids (less than C10) with the maximum activity towards tricaprylin (C8:0). Active against p- nitrophenylesters with fatty acid chain lengths from C6 to C18 | ABC-2 type transport system permease protein; Required for resistance to linearmycins, a family of antibiotic-specialized metabolites produced by some streptomycetes . Part of the ABC transporter complex LnrLMN that probably facilitates linearmycin removal from the membrane. Responsible for the translocation of the substrate across the membrane . Also mediates KinC-dependent biofilm morphology | 0.881 |
estB | yfiN | BSU08350 | BSU08330 | Extracellular esterase estb; An esterase which preferentially hydrolyzes triacylglyceride substrates with short chain fatty acids (less than C10) with the maximum activity towards tricaprylin (C8:0). Active against p- nitrophenylesters with fatty acid chain lengths from C6 to C18 | ABC-2 type transport system permease protein; Required for resistance to linearmycins, a family of antibiotic-specialized metabolites produced by some streptomycetes . Part of the ABC transporter complex LnrLMN that probably facilitates linearmycin removal from the membrane. Responsible for the translocation of the substrate across the membrane . Also mediates KinC-dependent biofilm morphology | 0.713 |
pksJ | pksM | BSU17180 | BSU17200 | Polyketide synthase of type i; Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism | Polyketide synthase pksm; Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism | 0.999 |
pksJ | yfiM | BSU17180 | BSU08320 | Polyketide synthase of type i; Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism | ABC-2 type transport system permease protein; Required for resistance to linearmycins, a family of antibiotic-specialized metabolites produced by some streptomycetes . Part of the ABC transporter complex LnrLMN that probably facilitates linearmycin removal from the membrane. Responsible for the translocation of the substrate across the membrane . Also mediates KinC-dependent biofilm morphology | 0.745 |
pksJ | yfiN | BSU17180 | BSU08330 | Polyketide synthase of type i; Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism | ABC-2 type transport system permease protein; Required for resistance to linearmycins, a family of antibiotic-specialized metabolites produced by some streptomycetes . Part of the ABC transporter complex LnrLMN that probably facilitates linearmycin removal from the membrane. Responsible for the translocation of the substrate across the membrane . Also mediates KinC-dependent biofilm morphology | 0.453 |
pksJ | yvrP | BSU17180 | BSU33280 | Polyketide synthase of type i; Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism | Putative efflux system protein YvrP; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter | 0.603 |
pksJ | yydI | BSU17180 | BSU40150 | Polyketide synthase of type i; Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism | Putative peptide transport system atp-binding protein; Suggested to be part of an ABC transporter complex YydIJ involved in export of the modified peptide YydF (Probable). Responsible for energy coupling to the transport system (By similarity) | 0.406 |
pksM | pksJ | BSU17200 | BSU17180 | Polyketide synthase pksm; Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism | Polyketide synthase of type i; Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism | 0.999 |
pksM | yfiM | BSU17200 | BSU08320 | Polyketide synthase pksm; Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism | ABC-2 type transport system permease protein; Required for resistance to linearmycins, a family of antibiotic-specialized metabolites produced by some streptomycetes . Part of the ABC transporter complex LnrLMN that probably facilitates linearmycin removal from the membrane. Responsible for the translocation of the substrate across the membrane . Also mediates KinC-dependent biofilm morphology | 0.757 |
pksM | yfiN | BSU17200 | BSU08330 | Polyketide synthase pksm; Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism | ABC-2 type transport system permease protein; Required for resistance to linearmycins, a family of antibiotic-specialized metabolites produced by some streptomycetes . Part of the ABC transporter complex LnrLMN that probably facilitates linearmycin removal from the membrane. Responsible for the translocation of the substrate across the membrane . Also mediates KinC-dependent biofilm morphology | 0.542 |
pksM | yvrP | BSU17200 | BSU33280 | Polyketide synthase pksm; Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism | Putative efflux system protein YvrP; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter | 0.638 |
pksM | yydI | BSU17200 | BSU40150 | Polyketide synthase pksm; Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism | Putative peptide transport system atp-binding protein; Suggested to be part of an ABC transporter complex YydIJ involved in export of the modified peptide YydF (Probable). Responsible for energy coupling to the transport system (By similarity) | 0.405 |
sspE | yfiJ | BSU08660 | BSU08290 | Small acid-soluble spore protein e (minor gamma-type sasp); SASP are proteins degraded in the first minutes of spore germination and provide amino acids for both new protein synthesis and metabolism. These proteins may be involved in dormant spore's high resistance to UV light | Two-component sensor histidine kinase [yfik]; Required for resistance to linearmycins, a family of antibiotic-specialized metabolites produced by some streptomycetes . Member of the two-component regulatory system LnrJ/LnrK, which induces expression of the LnrLMN ABC transporter in response to linearmycins and other polyenes . Acts as a specific sensor for linearmycin, either directly through binding or indirectly through membrane perturbation. Probably activates LnrK by phosphorylation . May also promote biofilm formation | 0.583 |
sspE | yfiK | BSU08660 | BSU08300 | Small acid-soluble spore protein e (minor gamma-type sasp); SASP are proteins degraded in the first minutes of spore germination and provide amino acids for both new protein synthesis and metabolism. These proteins may be involved in dormant spore's high resistance to UV light | Two-component system, narl family, response regulator; Required for resistance to linearmycins, a family of antibiotic-specialized metabolites produced by some streptomycetes . Member of the two-component regulatory system LnrJ/LnrK, which induces expression of the LnrLMN ABC transporter in response to linearmycins and other polyenes . Probably binds to the promoter region of the lnrLMN operon and directly regulates its expression (Probable). May also promote biofilm formation | 0.612 |
sspE | yfiL | BSU08660 | BSU08310 | Small acid-soluble spore protein e (minor gamma-type sasp); SASP are proteins degraded in the first minutes of spore germination and provide amino acids for both new protein synthesis and metabolism. These proteins may be involved in dormant spore's high resistance to UV light | ABC-2 type transport system ATP-binding protein; Required for resistance to linearmycins, a family of antibiotic-specialized metabolites produced by some streptomycetes . Part of the ABC transporter complex LnrLMN that probably facilitates linearmycin removal from the membrane. Responsible for energy coupling to the transport system . Also mediates KinC-dependent biofilm morphology | 0.580 |
sspE | yfiM | BSU08660 | BSU08320 | Small acid-soluble spore protein e (minor gamma-type sasp); SASP are proteins degraded in the first minutes of spore germination and provide amino acids for both new protein synthesis and metabolism. These proteins may be involved in dormant spore's high resistance to UV light | ABC-2 type transport system permease protein; Required for resistance to linearmycins, a family of antibiotic-specialized metabolites produced by some streptomycetes . Part of the ABC transporter complex LnrLMN that probably facilitates linearmycin removal from the membrane. Responsible for the translocation of the substrate across the membrane . Also mediates KinC-dependent biofilm morphology | 0.713 |
sspE | yfiN | BSU08660 | BSU08330 | Small acid-soluble spore protein e (minor gamma-type sasp); SASP are proteins degraded in the first minutes of spore germination and provide amino acids for both new protein synthesis and metabolism. These proteins may be involved in dormant spore's high resistance to UV light | ABC-2 type transport system permease protein; Required for resistance to linearmycins, a family of antibiotic-specialized metabolites produced by some streptomycetes . Part of the ABC transporter complex LnrLMN that probably facilitates linearmycin removal from the membrane. Responsible for the translocation of the substrate across the membrane . Also mediates KinC-dependent biofilm morphology | 0.589 |