STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
yfiRTranscriptional regulator (TetR/AcrR family); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type r: regulator. (205 aa)    
Predicted Functional Partners:
ycnC
Putative transcriptional regulator (TetR/AcrR family); Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr: putative regulator.
   
  
 0.903
yfiS
Putative efflux transporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter.
 
    0.835
yugK
Putative NADH-dependent butanol dehydrogenase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme.
      
 0.743
ykoH
Two-component sensor histidine kinase [YkoG]; Probable member of the two-component regulatory system YkoH/YkoG. Potentially phosphorylates YkoG.
      
 0.740
yflL
Putative acylphosphatase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the acylphosphatase family.
   
  
 0.578
bst
Bacillithiol S-transferase; Possible metal-dependent hydrolase; Belongs to the metal hydrolase YfiT family.
  
    0.553
fadR
Transcriptional regulator of fatty acids degradation (TetR/AcrR family); Transcriptional regulator in fatty acid degradation. Represses transcription of genes required for fatty acid transport and beta-oxidation, including acdA, fadA, fadB, fadE, fadF, fadG, fadH, fadM, fadN, lcfA and lcfB. Binding of FadR to DNA is specifically inhibited by long chain fatty acyl-CoA compounds of 14-20 carbon atoms in length.
  
    0.496
kamA
Lysine 2,3-aminomutase; Catalyzes the interconversion of L-alpha-lysine and L-beta- lysine; Belongs to the radical SAM superfamily. KamA family.
      
 0.450
helD
DNA 3'-5' helicase IV; Catalyzes the unwinding of duplex DNA in the 3' to 5' direction; this reaction is dependent on the hydrolysis of ATP.
      
 0.410
braB
Branched-chain amino acid-Na+ symporter; Component of the transport system for branched-chain amino acids (leucine, isoleucine and valine) Which is coupled to a proton motive force.
      
 0.408
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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