STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
prkASerine protein kinase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the PrkA family. (631 aa)    
Predicted Functional Partners:
spoVR
Involved in spore cortex synthesis (stage V sporulation); Appears to be involved in spore cortex formation.
 
  
 0.997
yhbH
Factor involved in shape determination (sporulation); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type f: factor.
  
 0.996
mgfK
Gluconeogenesis morphogenetic factor; Required for morphogenesis under gluconeogenic growth conditions. Required, in gluconeogenic growth conditions, for the correct localization of PBP1 and hence for displaying a normal rod shape; Belongs to the gluconeogenesis factor family.
      
 0.815
spoIVA
Morphogenetic stage IV sporulation protein; ATPase. Has a role at an early stage in the morphogenesis of the spore coat outer layers. Its ATP hydrolysis is required for proper assembly of the spore coat. Forms a basement layer around the outside surface of the forespore and self-assembles irreversibly into higher order structures by binding and hydrolyzing ATP thus creating a durable and stable platform upon which thereafter morphogenesis of the coat can take place. Required for proper localization of spore coat protein CotE and sporulation-specific proteins including SpoVM.
   
  
 0.776
cotE
Morphogenic spore protein; Morphogenic protein required for the assembly of the outer coat of the endospore. Is also a regulatory protein for the expression of cotA, cotB, cotC, cotH and other genes encoding spore outer coat proteins.
  
    0.766
glgA
Bacterial glycogen (starch) synthase; Synthesizes alpha-1,4-glucan chains using ADP-glucose; Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
   
    0.730
ylaK
Putative phosphate starvation inducible protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative factor; In the C-terminal section; belongs to the PhoH family.
   
  
 0.711
gerQ
Inner spore coat protein; Essential for the localization of CwlJ in the spore coat and for spore germination triggered by calcium and dipicolinic acid (DPA). Its assembly into the spore coat is dependent on the coat morphogenetic proteins CotE and SpoIVA.
  
    0.705
yhbB
Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function.
 
    0.701
katE
Catalase 2; Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide. Involved in sporulation.
   
  
 0.700
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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