STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yhcRNon specific extracellular endonuclease cleaving RNA and DNA; Sugar-nonspecific endonuclease that yields nucleotide 3'- monophosphate products. No 5'-nucleotidase activity was detected, using 5'-AMP as the substrate, in the presence of diverse divalent metals and with various pH values. (1217 aa)    
Predicted Functional Partners:
srtA
Sortase A; Transpeptidase that anchors surface proteins to the cell wall. Recognizes and modifies its substrate by proteolytic cleavage of a C-terminal sorting signal. Following cleavage, a covalent intermediate is formed via a thioester bond between the sortase and its substrate, which is then transferred and covalently attached to the cell wall (Probable). This sortase recognizes a Leu-Pro-Asp-Thr-Ser/Ala (LPDTS/A) motif. It has two substrates, YhcR and YfkN. Belongs to the bacterial sortase family. Class D subfamily.
  
  
 0.994
yhcY
Two-component sensor histidine kinase [YhcZ]; Member of the two-component regulatory system YhcY/YhcZ. Probably activates YhcZ by phosphorylation.
  
  
 0.787
ywpE
Putative sortase; Seems not to play a major role if any as a sortase.
  
  
 0.782
yncB
DNA nuclease, lipoprotein; Shows DNase activity on double strand DNA. Belongs to the thermonuclease family.
 
   
 0.769
yhcZ
Two-component response regulator [YhcY]; Member of the two-component regulatory system YhcY/YhcZ.
  
  
 0.748
ymfH
Putative processing protease; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme.
  
  
 0.697
yrrN
Putative hydrolase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the peptidase U32 family.
     
 0.690
yhcQ
Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function.
 
     0.628
bsn
Extracellular ribonuclease; Mg(2+)-activated ribonuclease which hydrolyzes RNA apparently nonspecifically into oligonucleotides with 5'-terminal phosphate.
  
  
 0.603
vpr
Extracellular serine protease; Not required for growth or sporulation.
  
  
 0.590
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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