STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
spoVRInvolved in spore cortex synthesis (stage V sporulation); Appears to be involved in spore cortex formation. (468 aa)    
Predicted Functional Partners:
prkA
Serine protein kinase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the PrkA family.
 
  
 0.997
yhbH
Factor involved in shape determination (sporulation); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type f: factor.
 
  
 0.991
spoVS
Stage V sporulation protein S; Induced early in sporulation under the control of sigma-H. Interferes with sporulation at an early stage. Seems to play a positive role in allowing cells to progress beyond stage V of sporulation.
   
  
 0.788
spoVFB
Spore dipicolinate synthase subunit B; Together with DpaA, catalyzes the conversion of dihydrodipicolinate to dipicolinate (DPA), which constitutes up to 10% of the dry weight of the spore.
  
  
 0.771
spoIIID
Transcriptional regulator; This protein regulates the transcription of sigK, which encodes mother cell chamber RNA polymerase sigma-factor (sigma K).
   
  
 0.731
cotE
Morphogenic spore protein; Morphogenic protein required for the assembly of the outer coat of the endospore. Is also a regulatory protein for the expression of cotA, cotB, cotC, cotH and other genes encoding spore outer coat proteins.
  
  
 0.712
gerQ
Inner spore coat protein; Essential for the localization of CwlJ in the spore coat and for spore germination triggered by calcium and dipicolinic acid (DPA). Its assembly into the spore coat is dependent on the coat morphogenetic proteins CotE and SpoIVA.
  
    0.701
yhbB
Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function.
 
    0.680
spmB
Spore maturation protein; Involved in spore core dehydration; might be involved in the transport of something into or out of the forespore or could be required for some modification of the cortex peptidoglycan structure; Belongs to the SpmB family.
   
  
 0.673
yknT
Hypothetical protein; Evidence 5: No homology to any previously reported sequences; PubMedId: 15383836, 15743949.
   
  
 0.671
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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