| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| arsR | copZ | BSU25810 | BSU33510 | Transcriptional regulator (ArsR family); Transcriptional repressor for the ars operon. | Copper insertion chaperone and transporter component; Chaperone that serves for the intracellular sequestration and transport of Cu(+). Delivers Cu(+) to the copper-transporting ATPase CopA. Functions in E.coli to transfer Cu(+) to CopA missing its first metal-binding domain. | 0.567 |
| arsR | csoR | BSU25810 | BSU33520 | Transcriptional regulator (ArsR family); Transcriptional repressor for the ars operon. | Repressor of copper utilisation proteins; Copper-sensitive repressor that has a key role in copper homeostasis. Negatively regulates expression of the copZA operon and of ycnJ. In the absence of copper ions, binds with high affinity to the copZA promoter and represses the transcription. In the presence of copper ions, CsoR binds Cu(1+), which significantly decreases its DNA binding affinity and leads to the transcription of the genes. | 0.923 |
| arsR | cueR | BSU25810 | BSU09560 | Transcriptional regulator (ArsR family); Transcriptional repressor for the ars operon. | Copper efflux transcriptional regulator; Transcriptional activator of the copZA operon. | 0.849 |
| arsR | czrA | BSU25810 | BSU19120 | Transcriptional regulator (ArsR family); Transcriptional repressor for the ars operon. | Transcriptional regulator (multiple metal-sensing ArsR-SmtB transcriptional repressors family); Metal-responsive transcriptional regulator that represses transcription of cadA and the czcD-trkA operon by binding specifically to their promoter. Binding of zinc causes the repressor to dissociate from the DNA. | 0.992 |
| arsR | ycnJ | BSU25810 | BSU03950 | Transcriptional regulator (ArsR family); Transcriptional repressor for the ars operon. | Putative copper import protein; Involved in uptake of extracellular oxidized copper under copper-limiting conditions; In the N-terminal section; belongs to the CopC family. | 0.572 |
| bltR | bmrR | BSU26580 | BSU24020 | Transcriptional regulator; Activates transcription of the blt gene in response to structurally dissimilar drugs. | Transcriptional regulator (MerR family); Activates transcription of the bmr gene in response to structurally dissimilar drugs. Binds rhodamine as an inducer. | 0.706 |
| bltR | cueR | BSU26580 | BSU09560 | Transcriptional regulator; Activates transcription of the blt gene in response to structurally dissimilar drugs. | Copper efflux transcriptional regulator; Transcriptional activator of the copZA operon. | 0.935 |
| bltR | mta | BSU26580 | BSU36600 | Transcriptional regulator; Activates transcription of the blt gene in response to structurally dissimilar drugs. | Transcriptional regulator (MerR family); Global transcriptional regulator that activates transcription of bmr and blt by binding directly to their promoter. Stimulates also the expression of the mta gene itself, ydfK and ymfE. | 0.649 |
| bltR | yyaN | BSU26580 | BSU40800 | Transcriptional regulator; Activates transcription of the blt gene in response to structurally dissimilar drugs. | Putative transcriptional regulator (MerR family); Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. | 0.464 |
| bmrR | bltR | BSU24020 | BSU26580 | Transcriptional regulator (MerR family); Activates transcription of the bmr gene in response to structurally dissimilar drugs. Binds rhodamine as an inducer. | Transcriptional regulator; Activates transcription of the blt gene in response to structurally dissimilar drugs. | 0.706 |
| bmrR | cueR | BSU24020 | BSU09560 | Transcriptional regulator (MerR family); Activates transcription of the bmr gene in response to structurally dissimilar drugs. Binds rhodamine as an inducer. | Copper efflux transcriptional regulator; Transcriptional activator of the copZA operon. | 0.942 |
| bmrR | czrA | BSU24020 | BSU19120 | Transcriptional regulator (MerR family); Activates transcription of the bmr gene in response to structurally dissimilar drugs. Binds rhodamine as an inducer. | Transcriptional regulator (multiple metal-sensing ArsR-SmtB transcriptional repressors family); Metal-responsive transcriptional regulator that represses transcription of cadA and the czcD-trkA operon by binding specifically to their promoter. Binding of zinc causes the repressor to dissociate from the DNA. | 0.433 |
| bmrR | mta | BSU24020 | BSU36600 | Transcriptional regulator (MerR family); Activates transcription of the bmr gene in response to structurally dissimilar drugs. Binds rhodamine as an inducer. | Transcriptional regulator (MerR family); Global transcriptional regulator that activates transcription of bmr and blt by binding directly to their promoter. Stimulates also the expression of the mta gene itself, ydfK and ymfE. | 0.975 |
| copZ | arsR | BSU33510 | BSU25810 | Copper insertion chaperone and transporter component; Chaperone that serves for the intracellular sequestration and transport of Cu(+). Delivers Cu(+) to the copper-transporting ATPase CopA. Functions in E.coli to transfer Cu(+) to CopA missing its first metal-binding domain. | Transcriptional regulator (ArsR family); Transcriptional repressor for the ars operon. | 0.567 |
| copZ | csoR | BSU33510 | BSU33520 | Copper insertion chaperone and transporter component; Chaperone that serves for the intracellular sequestration and transport of Cu(+). Delivers Cu(+) to the copper-transporting ATPase CopA. Functions in E.coli to transfer Cu(+) to CopA missing its first metal-binding domain. | Repressor of copper utilisation proteins; Copper-sensitive repressor that has a key role in copper homeostasis. Negatively regulates expression of the copZA operon and of ycnJ. In the absence of copper ions, binds with high affinity to the copZA promoter and represses the transcription. In the presence of copper ions, CsoR binds Cu(1+), which significantly decreases its DNA binding affinity and leads to the transcription of the genes. | 0.997 |
| copZ | cueR | BSU33510 | BSU09560 | Copper insertion chaperone and transporter component; Chaperone that serves for the intracellular sequestration and transport of Cu(+). Delivers Cu(+) to the copper-transporting ATPase CopA. Functions in E.coli to transfer Cu(+) to CopA missing its first metal-binding domain. | Copper efflux transcriptional regulator; Transcriptional activator of the copZA operon. | 0.928 |
| copZ | czrA | BSU33510 | BSU19120 | Copper insertion chaperone and transporter component; Chaperone that serves for the intracellular sequestration and transport of Cu(+). Delivers Cu(+) to the copper-transporting ATPase CopA. Functions in E.coli to transfer Cu(+) to CopA missing its first metal-binding domain. | Transcriptional regulator (multiple metal-sensing ArsR-SmtB transcriptional repressors family); Metal-responsive transcriptional regulator that represses transcription of cadA and the czcD-trkA operon by binding specifically to their promoter. Binding of zinc causes the repressor to dissociate from the DNA. | 0.558 |
| copZ | ycnJ | BSU33510 | BSU03950 | Copper insertion chaperone and transporter component; Chaperone that serves for the intracellular sequestration and transport of Cu(+). Delivers Cu(+) to the copper-transporting ATPase CopA. Functions in E.coli to transfer Cu(+) to CopA missing its first metal-binding domain. | Putative copper import protein; Involved in uptake of extracellular oxidized copper under copper-limiting conditions; In the N-terminal section; belongs to the CopC family. | 0.944 |
| copZ | yyaN | BSU33510 | BSU40800 | Copper insertion chaperone and transporter component; Chaperone that serves for the intracellular sequestration and transport of Cu(+). Delivers Cu(+) to the copper-transporting ATPase CopA. Functions in E.coli to transfer Cu(+) to CopA missing its first metal-binding domain. | Putative transcriptional regulator (MerR family); Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. | 0.622 |
| csoR | arsR | BSU33520 | BSU25810 | Repressor of copper utilisation proteins; Copper-sensitive repressor that has a key role in copper homeostasis. Negatively regulates expression of the copZA operon and of ycnJ. In the absence of copper ions, binds with high affinity to the copZA promoter and represses the transcription. In the presence of copper ions, CsoR binds Cu(1+), which significantly decreases its DNA binding affinity and leads to the transcription of the genes. | Transcriptional regulator (ArsR family); Transcriptional repressor for the ars operon. | 0.923 |
STRING v12.5 is now available!
