node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
glcP | ntdA | BSU10520 | BSU10550 | glucose/mannose:H+ symporter; Can transport glucose, mannose, 2-deoxyglucose and methyl alpha-glucoside, but not galactose. | 3-oxo-glucose-6-phosphate:glutamate aminotransferase; Involved in the biosynthesis of kanosamine (3-amino-3-deoxy- D-glucose), which is known to have antibiotic and antifungal properties, and to be a precursor of the antibiotic neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha,beta-trehalose (NTD)). Catalyzes the reversible pyridoxal phosphate-dependent transamination of 3-dehydro- alpha-D-glucose 6-phosphate to form alpha-D-kanosamine-6-phosphate. It can only use alpha-anomer and glutamate is the only amino donor. | 0.654 |
glcP | ntdB | BSU10520 | BSU10540 | glucose/mannose:H+ symporter; Can transport glucose, mannose, 2-deoxyglucose and methyl alpha-glucoside, but not galactose. | Biosynthesis of neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha, beta-trehalose);hydrolase; Involved in the biosynthesis of kanosamine (3-amino-3-deoxy- D-glucose), which is known to have antibiotic and antifungal properties, and to be a precursor of the antibiotic neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha,beta-trehalose (NTD)). Catalyzes the dephosphorylation of kanosamine 6-phosphate to yield kanosamine. There is a trace amount of activity using glucosamine-6-phosphate. Belongs to the HAD-like hydrolase superfamily. Cof family. | 0.788 |
glcP | ntdC | BSU10520 | BSU10530 | glucose/mannose:H+ symporter; Can transport glucose, mannose, 2-deoxyglucose and methyl alpha-glucoside, but not galactose. | Biosynthesis of neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha,beta-trehalose), dehydrogenase; Involved in the biosynthesis of kanosamine (3-amino-3-deoxy- D-glucose), which is known to have antibiotic and antifungal properties, and to be a precursor of the antibiotic neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha,beta-trehalose (NTD)). Catalyzes the oxidation of glucose 6-phosphate to 3-oxo-D-glucose 6-phosphate. It can only use NAD. | 0.793 |
glcP | yhjM | BSU10520 | BSU10560 | glucose/mannose:H+ symporter; Can transport glucose, mannose, 2-deoxyglucose and methyl alpha-glucoside, but not galactose. | Transcriptional regulator of the ntd operon; Positively regulates the ntdABC operon and negatively regulates its own transcription. Binds to NTD to induce ntdABC transcription. | 0.443 |
ntdA | glcP | BSU10550 | BSU10520 | 3-oxo-glucose-6-phosphate:glutamate aminotransferase; Involved in the biosynthesis of kanosamine (3-amino-3-deoxy- D-glucose), which is known to have antibiotic and antifungal properties, and to be a precursor of the antibiotic neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha,beta-trehalose (NTD)). Catalyzes the reversible pyridoxal phosphate-dependent transamination of 3-dehydro- alpha-D-glucose 6-phosphate to form alpha-D-kanosamine-6-phosphate. It can only use alpha-anomer and glutamate is the only amino donor. | glucose/mannose:H+ symporter; Can transport glucose, mannose, 2-deoxyglucose and methyl alpha-glucoside, but not galactose. | 0.654 |
ntdA | ntdB | BSU10550 | BSU10540 | 3-oxo-glucose-6-phosphate:glutamate aminotransferase; Involved in the biosynthesis of kanosamine (3-amino-3-deoxy- D-glucose), which is known to have antibiotic and antifungal properties, and to be a precursor of the antibiotic neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha,beta-trehalose (NTD)). Catalyzes the reversible pyridoxal phosphate-dependent transamination of 3-dehydro- alpha-D-glucose 6-phosphate to form alpha-D-kanosamine-6-phosphate. It can only use alpha-anomer and glutamate is the only amino donor. | Biosynthesis of neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha, beta-trehalose);hydrolase; Involved in the biosynthesis of kanosamine (3-amino-3-deoxy- D-glucose), which is known to have antibiotic and antifungal properties, and to be a precursor of the antibiotic neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha,beta-trehalose (NTD)). Catalyzes the dephosphorylation of kanosamine 6-phosphate to yield kanosamine. There is a trace amount of activity using glucosamine-6-phosphate. Belongs to the HAD-like hydrolase superfamily. Cof family. | 0.999 |
ntdA | ntdC | BSU10550 | BSU10530 | 3-oxo-glucose-6-phosphate:glutamate aminotransferase; Involved in the biosynthesis of kanosamine (3-amino-3-deoxy- D-glucose), which is known to have antibiotic and antifungal properties, and to be a precursor of the antibiotic neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha,beta-trehalose (NTD)). Catalyzes the reversible pyridoxal phosphate-dependent transamination of 3-dehydro- alpha-D-glucose 6-phosphate to form alpha-D-kanosamine-6-phosphate. It can only use alpha-anomer and glutamate is the only amino donor. | Biosynthesis of neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha,beta-trehalose), dehydrogenase; Involved in the biosynthesis of kanosamine (3-amino-3-deoxy- D-glucose), which is known to have antibiotic and antifungal properties, and to be a precursor of the antibiotic neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha,beta-trehalose (NTD)). Catalyzes the oxidation of glucose 6-phosphate to 3-oxo-D-glucose 6-phosphate. It can only use NAD. | 0.999 |
ntdA | yhjM | BSU10550 | BSU10560 | 3-oxo-glucose-6-phosphate:glutamate aminotransferase; Involved in the biosynthesis of kanosamine (3-amino-3-deoxy- D-glucose), which is known to have antibiotic and antifungal properties, and to be a precursor of the antibiotic neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha,beta-trehalose (NTD)). Catalyzes the reversible pyridoxal phosphate-dependent transamination of 3-dehydro- alpha-D-glucose 6-phosphate to form alpha-D-kanosamine-6-phosphate. It can only use alpha-anomer and glutamate is the only amino donor. | Transcriptional regulator of the ntd operon; Positively regulates the ntdABC operon and negatively regulates its own transcription. Binds to NTD to induce ntdABC transcription. | 0.550 |
ntdA | yugH | BSU10550 | BSU31400 | 3-oxo-glucose-6-phosphate:glutamate aminotransferase; Involved in the biosynthesis of kanosamine (3-amino-3-deoxy- D-glucose), which is known to have antibiotic and antifungal properties, and to be a precursor of the antibiotic neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha,beta-trehalose (NTD)). Catalyzes the reversible pyridoxal phosphate-dependent transamination of 3-dehydro- alpha-D-glucose 6-phosphate to form alpha-D-kanosamine-6-phosphate. It can only use alpha-anomer and glutamate is the only amino donor. | Putative aspartate aminotransferase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. | 0.505 |
ntdB | glcP | BSU10540 | BSU10520 | Biosynthesis of neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha, beta-trehalose);hydrolase; Involved in the biosynthesis of kanosamine (3-amino-3-deoxy- D-glucose), which is known to have antibiotic and antifungal properties, and to be a precursor of the antibiotic neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha,beta-trehalose (NTD)). Catalyzes the dephosphorylation of kanosamine 6-phosphate to yield kanosamine. There is a trace amount of activity using glucosamine-6-phosphate. Belongs to the HAD-like hydrolase superfamily. Cof family. | glucose/mannose:H+ symporter; Can transport glucose, mannose, 2-deoxyglucose and methyl alpha-glucoside, but not galactose. | 0.788 |
ntdB | ntdA | BSU10540 | BSU10550 | Biosynthesis of neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha, beta-trehalose);hydrolase; Involved in the biosynthesis of kanosamine (3-amino-3-deoxy- D-glucose), which is known to have antibiotic and antifungal properties, and to be a precursor of the antibiotic neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha,beta-trehalose (NTD)). Catalyzes the dephosphorylation of kanosamine 6-phosphate to yield kanosamine. There is a trace amount of activity using glucosamine-6-phosphate. Belongs to the HAD-like hydrolase superfamily. Cof family. | 3-oxo-glucose-6-phosphate:glutamate aminotransferase; Involved in the biosynthesis of kanosamine (3-amino-3-deoxy- D-glucose), which is known to have antibiotic and antifungal properties, and to be a precursor of the antibiotic neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha,beta-trehalose (NTD)). Catalyzes the reversible pyridoxal phosphate-dependent transamination of 3-dehydro- alpha-D-glucose 6-phosphate to form alpha-D-kanosamine-6-phosphate. It can only use alpha-anomer and glutamate is the only amino donor. | 0.999 |
ntdB | ntdC | BSU10540 | BSU10530 | Biosynthesis of neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha, beta-trehalose);hydrolase; Involved in the biosynthesis of kanosamine (3-amino-3-deoxy- D-glucose), which is known to have antibiotic and antifungal properties, and to be a precursor of the antibiotic neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha,beta-trehalose (NTD)). Catalyzes the dephosphorylation of kanosamine 6-phosphate to yield kanosamine. There is a trace amount of activity using glucosamine-6-phosphate. Belongs to the HAD-like hydrolase superfamily. Cof family. | Biosynthesis of neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha,beta-trehalose), dehydrogenase; Involved in the biosynthesis of kanosamine (3-amino-3-deoxy- D-glucose), which is known to have antibiotic and antifungal properties, and to be a precursor of the antibiotic neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha,beta-trehalose (NTD)). Catalyzes the oxidation of glucose 6-phosphate to 3-oxo-D-glucose 6-phosphate. It can only use NAD. | 0.996 |
ntdB | yhjM | BSU10540 | BSU10560 | Biosynthesis of neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha, beta-trehalose);hydrolase; Involved in the biosynthesis of kanosamine (3-amino-3-deoxy- D-glucose), which is known to have antibiotic and antifungal properties, and to be a precursor of the antibiotic neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha,beta-trehalose (NTD)). Catalyzes the dephosphorylation of kanosamine 6-phosphate to yield kanosamine. There is a trace amount of activity using glucosamine-6-phosphate. Belongs to the HAD-like hydrolase superfamily. Cof family. | Transcriptional regulator of the ntd operon; Positively regulates the ntdABC operon and negatively regulates its own transcription. Binds to NTD to induce ntdABC transcription. | 0.558 |
ntdB | yugH | BSU10540 | BSU31400 | Biosynthesis of neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha, beta-trehalose);hydrolase; Involved in the biosynthesis of kanosamine (3-amino-3-deoxy- D-glucose), which is known to have antibiotic and antifungal properties, and to be a precursor of the antibiotic neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha,beta-trehalose (NTD)). Catalyzes the dephosphorylation of kanosamine 6-phosphate to yield kanosamine. There is a trace amount of activity using glucosamine-6-phosphate. Belongs to the HAD-like hydrolase superfamily. Cof family. | Putative aspartate aminotransferase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. | 0.404 |
ntdC | glcP | BSU10530 | BSU10520 | Biosynthesis of neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha,beta-trehalose), dehydrogenase; Involved in the biosynthesis of kanosamine (3-amino-3-deoxy- D-glucose), which is known to have antibiotic and antifungal properties, and to be a precursor of the antibiotic neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha,beta-trehalose (NTD)). Catalyzes the oxidation of glucose 6-phosphate to 3-oxo-D-glucose 6-phosphate. It can only use NAD. | glucose/mannose:H+ symporter; Can transport glucose, mannose, 2-deoxyglucose and methyl alpha-glucoside, but not galactose. | 0.793 |
ntdC | ntdA | BSU10530 | BSU10550 | Biosynthesis of neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha,beta-trehalose), dehydrogenase; Involved in the biosynthesis of kanosamine (3-amino-3-deoxy- D-glucose), which is known to have antibiotic and antifungal properties, and to be a precursor of the antibiotic neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha,beta-trehalose (NTD)). Catalyzes the oxidation of glucose 6-phosphate to 3-oxo-D-glucose 6-phosphate. It can only use NAD. | 3-oxo-glucose-6-phosphate:glutamate aminotransferase; Involved in the biosynthesis of kanosamine (3-amino-3-deoxy- D-glucose), which is known to have antibiotic and antifungal properties, and to be a precursor of the antibiotic neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha,beta-trehalose (NTD)). Catalyzes the reversible pyridoxal phosphate-dependent transamination of 3-dehydro- alpha-D-glucose 6-phosphate to form alpha-D-kanosamine-6-phosphate. It can only use alpha-anomer and glutamate is the only amino donor. | 0.999 |
ntdC | ntdB | BSU10530 | BSU10540 | Biosynthesis of neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha,beta-trehalose), dehydrogenase; Involved in the biosynthesis of kanosamine (3-amino-3-deoxy- D-glucose), which is known to have antibiotic and antifungal properties, and to be a precursor of the antibiotic neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha,beta-trehalose (NTD)). Catalyzes the oxidation of glucose 6-phosphate to 3-oxo-D-glucose 6-phosphate. It can only use NAD. | Biosynthesis of neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha, beta-trehalose);hydrolase; Involved in the biosynthesis of kanosamine (3-amino-3-deoxy- D-glucose), which is known to have antibiotic and antifungal properties, and to be a precursor of the antibiotic neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha,beta-trehalose (NTD)). Catalyzes the dephosphorylation of kanosamine 6-phosphate to yield kanosamine. There is a trace amount of activity using glucosamine-6-phosphate. Belongs to the HAD-like hydrolase superfamily. Cof family. | 0.996 |
ntdC | yhjM | BSU10530 | BSU10560 | Biosynthesis of neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha,beta-trehalose), dehydrogenase; Involved in the biosynthesis of kanosamine (3-amino-3-deoxy- D-glucose), which is known to have antibiotic and antifungal properties, and to be a precursor of the antibiotic neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha,beta-trehalose (NTD)). Catalyzes the oxidation of glucose 6-phosphate to 3-oxo-D-glucose 6-phosphate. It can only use NAD. | Transcriptional regulator of the ntd operon; Positively regulates the ntdABC operon and negatively regulates its own transcription. Binds to NTD to induce ntdABC transcription. | 0.610 |
yhjM | glcP | BSU10560 | BSU10520 | Transcriptional regulator of the ntd operon; Positively regulates the ntdABC operon and negatively regulates its own transcription. Binds to NTD to induce ntdABC transcription. | glucose/mannose:H+ symporter; Can transport glucose, mannose, 2-deoxyglucose and methyl alpha-glucoside, but not galactose. | 0.443 |
yhjM | ntdA | BSU10560 | BSU10550 | Transcriptional regulator of the ntd operon; Positively regulates the ntdABC operon and negatively regulates its own transcription. Binds to NTD to induce ntdABC transcription. | 3-oxo-glucose-6-phosphate:glutamate aminotransferase; Involved in the biosynthesis of kanosamine (3-amino-3-deoxy- D-glucose), which is known to have antibiotic and antifungal properties, and to be a precursor of the antibiotic neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha,beta-trehalose (NTD)). Catalyzes the reversible pyridoxal phosphate-dependent transamination of 3-dehydro- alpha-D-glucose 6-phosphate to form alpha-D-kanosamine-6-phosphate. It can only use alpha-anomer and glutamate is the only amino donor. | 0.550 |