STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ntdA3-oxo-glucose-6-phosphate:glutamate aminotransferase; Involved in the biosynthesis of kanosamine (3-amino-3-deoxy- D-glucose), which is known to have antibiotic and antifungal properties, and to be a precursor of the antibiotic neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha,beta-trehalose (NTD)). Catalyzes the reversible pyridoxal phosphate-dependent transamination of 3-dehydro- alpha-D-glucose 6-phosphate to form alpha-D-kanosamine-6-phosphate. It can only use alpha-anomer and glutamate is the only amino donor. (441 aa)    
Predicted Functional Partners:
ntdC
Biosynthesis of neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha,beta-trehalose), dehydrogenase; Involved in the biosynthesis of kanosamine (3-amino-3-deoxy- D-glucose), which is known to have antibiotic and antifungal properties, and to be a precursor of the antibiotic neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha,beta-trehalose (NTD)). Catalyzes the oxidation of glucose 6-phosphate to 3-oxo-D-glucose 6-phosphate. It can only use NAD.
 
 
 0.999
ntdB
Biosynthesis of neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha, beta-trehalose);hydrolase; Involved in the biosynthesis of kanosamine (3-amino-3-deoxy- D-glucose), which is known to have antibiotic and antifungal properties, and to be a precursor of the antibiotic neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha,beta-trehalose (NTD)). Catalyzes the dephosphorylation of kanosamine 6-phosphate to yield kanosamine. There is a trace amount of activity using glucosamine-6-phosphate. Belongs to the HAD-like hydrolase superfamily. Cof family.
  
 
 0.999
epsC
Putative UDP-sugar epimerase; Involved in biofilm formation; Belongs to the polysaccharide synthase family.
  
 0.886
epsM
Putative O-acetyltransferase; Catalyzes the conversion of UDP-2,4,6-trideoxy-2-acetamido-4- amino glucose to UDP-2,4,6-trideoxy-2,4-diacetamido glucose, commonly known as UDP-N,N'-diacetylbacillosamine (UDP-diNAcBac). Belongs to the transferase hexapeptide repeat family.
  
 0.789
spsE
Putative phosphoenolpyruvate-sugar pyruvyltransferase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
 
  
 0.706
spsJ
dTDP-glucose 4,6-dehydratase; Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6- deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction.
 
  
 0.705
spsG
Putative glycosyltransferase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; To M.jannaschii MJ1062.
 
  
 0.681
glcP
glucose/mannose:H+ symporter; Can transport glucose, mannose, 2-deoxyglucose and methyl alpha-glucoside, but not galactose.
  
    0.654
spsF
Putative glycosyltransferase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme.
 
   
 0.654
mnaA
UDP-N-acetylmannosamine 2-epimerase; Catalyzes the conversion of UDP-N-acetylglucosamine into UDP- N-acetylmannosamine, a precursor of the teichoic acid linkage unit.
  
  
 0.653
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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