STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yitOPutative integral inner membrane protein with HTTM domain; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm: putative membrane component. (309 aa)    
Predicted Functional Partners:
yitP
Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; PubMedId: 6289325.
  
  
 0.993
yitM
Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function.
  
  
 0.982
sdpA
Export of killing factor; Required for the maturation of SdpC to SDP. Not required for SdpC signal peptide cleavage, secretion from the cell or disulfide bond formation.
  
  
 0.847
yizB
Putative DNA/RNA binding protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf: putative factor.
  
  
 0.842
fruK
Fructose-1-phosphate kinase; Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; Product type e: enzyme.
  
    0.733
yitR
Hypothetical protein; Evidence 5: No homology to any previously reported sequences.
     
 0.716
yitQ
Hypothetical protein; Evidence 5: No homology to any previously reported sequences.
     
 0.686
nprB
Extracellular neutral protease B; Protease able to cleave casein in vitro. Belongs to the peptidase M4 family.
  
  
 0.670
pksJ
Polyketide synthase of type I; Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism.
  
  
 0.523
spbC
Killing factor SdpC; Produces a 42-residue extracellular sporulation delaying protein (SDP) that collapses the proton motive force (probably both the membrane potential and pH gradient) across the cell membrane, which leads to autolysis; may form a proton channel. Induces the lysis of other B.subtilis cells that have not entered the sporulation pathway, inducing cannibalism to provide a source of nutrients to support sporulation, and at the same time delaying commitment to the energetically expensive and irreversible onset of sporulation. Addition of SDP to liquid cultures halts growth [...]
  
  
 0.509
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.