Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
pepFEvidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. (670 aa)    
Predicted Functional Partners:
pepT
Peptidase T (tripeptidase); Cleaves the N-terminal amino acid of tripeptides. Belongs to the peptidase M20B family.
  
  
 0.957
coiA
Protein involved in establishment of DNA transport in competence; Required for optimal transformation.
  
  
 0.877
ykvY
Putative Xaa-Pro dipeptidase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
   
  
 0.827
dtpT
Di-tripeptide-proton ABC symporter; Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; Product type t: transporter.
  
  
 0.767
yusZ
Oligoendopeptidase; Evidence 7: Gene remnant; Product type e: enzyme; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
     
 0.734
pepA
Leucyl aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides (By similarity).
  
  
 0.698
pcp
Pyrrolidone-carboxylate peptidase; Removes 5-oxoproline from various penultimate amino acid residues except L-proline; Belongs to the peptidase C15 family.
   
  
 0.649
ampS
Aminopeptidase; Metal-dependent exopeptidase; Belongs to the peptidase M29 family.
 
  
 0.594
mecA
Adaptor protein controlling oligomerization of the AAA+ protein ClpC; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC.
  
  
 0.588
ccpA
Transcriptional regulator (Lacl family); Global transcriptional regulator of carbon catabolite repression (CCR) and carbon catabolite activation (CCA), which ensures optimal energy usage under diverse conditions. Interacts with either P- Ser-HPr or P-Ser-Crh, leading to the formation of a complex that binds to DNA at the catabolite-response elements (cre). Binding to DNA allows activation or repression of many different genes and operons.
    
   0.587
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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