node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
bacE | rapA | BSU37700 | BSU12430 | Efflux protein for bacilysin excretion, self-protection against bacilysin; Part of the bacilysin biosynthesis operon. May be involved in self-resistance to bacilysin by permitting efflux of this antibiotic. | Response regulator aspartate phosphatase; Prevents sporulation by dephosphorylating Spo0F. Belongs to the RAP family. | 0.560 |
bceB | rapA | BSU30370 | BSU12430 | ABC transporter (permease); Part of the ABC transporter complex BceAB (TC 3.A.1.123.5) involved in bacitracin export; Belongs to the ABC-4 integral membrane protein family. | Response regulator aspartate phosphatase; Prevents sporulation by dephosphorylating Spo0F. Belongs to the RAP family. | 0.545 |
bceB | ybxI | BSU30370 | BSU02090 | ABC transporter (permease); Part of the ABC transporter complex BceAB (TC 3.A.1.123.5) involved in bacitracin export; Belongs to the ABC-4 integral membrane protein family. | Exported beta-lactamase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. | 0.913 |
comA | rapA | BSU31680 | BSU12430 | Two-component response regulator; Response regulator in the two-component regulatory system ComP/ComA involved in a major quorum response pathway that regulates the development of genetic competence. Regulates directly the expression of over 20 genes, including genes of the srfA operon, degQ, rapA, rapC, rapE, rapF, etc. Regulates indirectly, through the regulation of comK transcription, the expression of late competence genes. | Response regulator aspartate phosphatase; Prevents sporulation by dephosphorylating Spo0F. Belongs to the RAP family. | 0.687 |
phrA | rapA | BSU12440 | BSU12430 | Secreted inhibitor of the activity of phosphatase RapA; Inhibitor of the activity of phosphatase RapA. | Response regulator aspartate phosphatase; Prevents sporulation by dephosphorylating Spo0F. Belongs to the RAP family. | 0.999 |
phrA | spo0F | BSU12440 | BSU37130 | Secreted inhibitor of the activity of phosphatase RapA; Inhibitor of the activity of phosphatase RapA. | Two-component response regulator; Key element in the phosphorelay regulating sporulation initiation. Phosphorylation of spo0B during sporulation initiation. | 0.921 |
phrA | yydF | BSU12440 | BSU40180 | Secreted inhibitor of the activity of phosphatase RapA; Inhibitor of the activity of phosphatase RapA. | Peptide controlling LiaRS; Suggested to be the precursor for an exported, modified peptide that has antimicrobial and/or signaling properties. Synthesis requires YydG and YydH; the peptide is proposed to be exported by the YydIJ transporter. In the absence of the transporter, the modified peptide activates the LiaRS two-component regulatory system, possibly by eliciting cell envelope stress. This activation can occur in trans in cocultured cells lacking either the transporter or the whole operon. | 0.501 |
rapA | bacE | BSU12430 | BSU37700 | Response regulator aspartate phosphatase; Prevents sporulation by dephosphorylating Spo0F. Belongs to the RAP family. | Efflux protein for bacilysin excretion, self-protection against bacilysin; Part of the bacilysin biosynthesis operon. May be involved in self-resistance to bacilysin by permitting efflux of this antibiotic. | 0.560 |
rapA | bceB | BSU12430 | BSU30370 | Response regulator aspartate phosphatase; Prevents sporulation by dephosphorylating Spo0F. Belongs to the RAP family. | ABC transporter (permease); Part of the ABC transporter complex BceAB (TC 3.A.1.123.5) involved in bacitracin export; Belongs to the ABC-4 integral membrane protein family. | 0.545 |
rapA | comA | BSU12430 | BSU31680 | Response regulator aspartate phosphatase; Prevents sporulation by dephosphorylating Spo0F. Belongs to the RAP family. | Two-component response regulator; Response regulator in the two-component regulatory system ComP/ComA involved in a major quorum response pathway that regulates the development of genetic competence. Regulates directly the expression of over 20 genes, including genes of the srfA operon, degQ, rapA, rapC, rapE, rapF, etc. Regulates indirectly, through the regulation of comK transcription, the expression of late competence genes. | 0.687 |
rapA | phrA | BSU12430 | BSU12440 | Response regulator aspartate phosphatase; Prevents sporulation by dephosphorylating Spo0F. Belongs to the RAP family. | Secreted inhibitor of the activity of phosphatase RapA; Inhibitor of the activity of phosphatase RapA. | 0.999 |
rapA | spo0F | BSU12430 | BSU37130 | Response regulator aspartate phosphatase; Prevents sporulation by dephosphorylating Spo0F. Belongs to the RAP family. | Two-component response regulator; Key element in the phosphorelay regulating sporulation initiation. Phosphorylation of spo0B during sporulation initiation. | 0.964 |
rapA | xtmA | BSU12430 | BSU12570 | Response regulator aspartate phosphatase; Prevents sporulation by dephosphorylating Spo0F. Belongs to the RAP family. | PBSX defective prophage terminase (small subunit); Functions as a terminase; To B.subtilis YqaS and B.subtilis phage SPP1 terminase small subunit. | 0.566 |
rapA | yaaC | BSU12430 | BSU00080 | Response regulator aspartate phosphatase; Prevents sporulation by dephosphorylating Spo0F. Belongs to the RAP family. | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. | 0.508 |
rapA | ybxI | BSU12430 | BSU02090 | Response regulator aspartate phosphatase; Prevents sporulation by dephosphorylating Spo0F. Belongs to the RAP family. | Exported beta-lactamase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. | 0.626 |
rapA | ydaH | BSU12430 | BSU04230 | Response regulator aspartate phosphatase; Prevents sporulation by dephosphorylating Spo0F. Belongs to the RAP family. | Putative integral inner membrane protein; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. May serve as a defense mechanism against naturally occurring MurJ antagonists. | 0.505 |
rapA | yydF | BSU12430 | BSU40180 | Response regulator aspartate phosphatase; Prevents sporulation by dephosphorylating Spo0F. Belongs to the RAP family. | Peptide controlling LiaRS; Suggested to be the precursor for an exported, modified peptide that has antimicrobial and/or signaling properties. Synthesis requires YydG and YydH; the peptide is proposed to be exported by the YydIJ transporter. In the absence of the transporter, the modified peptide activates the LiaRS two-component regulatory system, possibly by eliciting cell envelope stress. This activation can occur in trans in cocultured cells lacking either the transporter or the whole operon. | 0.524 |
spo0F | phrA | BSU37130 | BSU12440 | Two-component response regulator; Key element in the phosphorelay regulating sporulation initiation. Phosphorylation of spo0B during sporulation initiation. | Secreted inhibitor of the activity of phosphatase RapA; Inhibitor of the activity of phosphatase RapA. | 0.921 |
spo0F | rapA | BSU37130 | BSU12430 | Two-component response regulator; Key element in the phosphorelay regulating sporulation initiation. Phosphorylation of spo0B during sporulation initiation. | Response regulator aspartate phosphatase; Prevents sporulation by dephosphorylating Spo0F. Belongs to the RAP family. | 0.964 |
xtmA | rapA | BSU12570 | BSU12430 | PBSX defective prophage terminase (small subunit); Functions as a terminase; To B.subtilis YqaS and B.subtilis phage SPP1 terminase small subunit. | Response regulator aspartate phosphatase; Prevents sporulation by dephosphorylating Spo0F. Belongs to the RAP family. | 0.566 |