| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| pit | spoIISA | BSU12840 | BSU12830 | Low-affinity inorganic phosphate transporter; Low-affinity inorganic phosphate transport; Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family. Pit subfamily. | Two-component apoptosis factor (toxin/antitoxin system); Toxic component of a type II toxin-antitoxin (TA) system. Its toxic activity is neutralized by cognate antitoxin SpoIISB. Expression in the absence of SpoIISB permits sporulation to stage II, when plasmolysis zones and holes in the peptidoglycan layer are observed, resulting in cell death. Lethal when synthesized during vegetative growth in the absence of SpoIISB. In E.coli both the membrane bound and soluble domain are required in cis for toxin activity. | 0.516 |
| pit | spoIISB | BSU12840 | BSU12820 | Low-affinity inorganic phosphate transporter; Low-affinity inorganic phosphate transport; Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family. Pit subfamily. | Two-component apoptotic control system component B (antitoxin); Antitoxin component of a type II toxin-antitoxin (TA) system. Antitoxin that binds cognate toxin SpoIISA and neutralizes its toxic activity; unlike most antitoxins it does not seem to be highly labile upon expression in E.coli. | 0.516 |
| pit | ykaA | BSU12840 | BSU12850 | Low-affinity inorganic phosphate transporter; Low-affinity inorganic phosphate transport; Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family. Pit subfamily. | Putative Pit accessory protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative factor; Belongs to the UPF0111 family. | 0.994 |
| spoIISA | pit | BSU12830 | BSU12840 | Two-component apoptosis factor (toxin/antitoxin system); Toxic component of a type II toxin-antitoxin (TA) system. Its toxic activity is neutralized by cognate antitoxin SpoIISB. Expression in the absence of SpoIISB permits sporulation to stage II, when plasmolysis zones and holes in the peptidoglycan layer are observed, resulting in cell death. Lethal when synthesized during vegetative growth in the absence of SpoIISB. In E.coli both the membrane bound and soluble domain are required in cis for toxin activity. | Low-affinity inorganic phosphate transporter; Low-affinity inorganic phosphate transport; Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family. Pit subfamily. | 0.516 |
| spoIISA | spoIISB | BSU12830 | BSU12820 | Two-component apoptosis factor (toxin/antitoxin system); Toxic component of a type II toxin-antitoxin (TA) system. Its toxic activity is neutralized by cognate antitoxin SpoIISB. Expression in the absence of SpoIISB permits sporulation to stage II, when plasmolysis zones and holes in the peptidoglycan layer are observed, resulting in cell death. Lethal when synthesized during vegetative growth in the absence of SpoIISB. In E.coli both the membrane bound and soluble domain are required in cis for toxin activity. | Two-component apoptotic control system component B (antitoxin); Antitoxin component of a type II toxin-antitoxin (TA) system. Antitoxin that binds cognate toxin SpoIISA and neutralizes its toxic activity; unlike most antitoxins it does not seem to be highly labile upon expression in E.coli. | 0.999 |
| spoIISA | spoVIF | BSU12830 | BSU11810 | Two-component apoptosis factor (toxin/antitoxin system); Toxic component of a type II toxin-antitoxin (TA) system. Its toxic activity is neutralized by cognate antitoxin SpoIISB. Expression in the absence of SpoIISB permits sporulation to stage II, when plasmolysis zones and holes in the peptidoglycan layer are observed, resulting in cell death. Lethal when synthesized during vegetative growth in the absence of SpoIISB. In E.coli both the membrane bound and soluble domain are required in cis for toxin activity. | Sporulation-specific protein needed for heat resistance; Transcription factor involved in spore coat assembly and spore resistance. Regulates the transcription of at least cgeA, cotG and cotS. | 0.408 |
| spoIISA | ycgB | BSU12830 | BSU03030 | Two-component apoptosis factor (toxin/antitoxin system); Toxic component of a type II toxin-antitoxin (TA) system. Its toxic activity is neutralized by cognate antitoxin SpoIISB. Expression in the absence of SpoIISB permits sporulation to stage II, when plasmolysis zones and holes in the peptidoglycan layer are observed, resulting in cell death. Lethal when synthesized during vegetative growth in the absence of SpoIISB. In E.coli both the membrane bound and soluble domain are required in cis for toxin activity. | Putative integral inner membrane protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm: putative membrane component. | 0.689 |
| spoIISA | yitR | BSU12830 | BSU11090 | Two-component apoptosis factor (toxin/antitoxin system); Toxic component of a type II toxin-antitoxin (TA) system. Its toxic activity is neutralized by cognate antitoxin SpoIISB. Expression in the absence of SpoIISB permits sporulation to stage II, when plasmolysis zones and holes in the peptidoglycan layer are observed, resulting in cell death. Lethal when synthesized during vegetative growth in the absence of SpoIISB. In E.coli both the membrane bound and soluble domain are required in cis for toxin activity. | Hypothetical protein; Evidence 5: No homology to any previously reported sequences. | 0.572 |
| spoIISA | yitS | BSU12830 | BSU11110 | Two-component apoptosis factor (toxin/antitoxin system); Toxic component of a type II toxin-antitoxin (TA) system. Its toxic activity is neutralized by cognate antitoxin SpoIISB. Expression in the absence of SpoIISB permits sporulation to stage II, when plasmolysis zones and holes in the peptidoglycan layer are observed, resulting in cell death. Lethal when synthesized during vegetative growth in the absence of SpoIISB. In E.coli both the membrane bound and soluble domain are required in cis for toxin activity. | Conserved hypothetical protein; May bind long-chain fatty acids, such as palmitate, and may play a role in lipid transport or fatty acid metabolism. | 0.494 |
| spoIISA | yjcD | BSU12830 | BSU11820 | Two-component apoptosis factor (toxin/antitoxin system); Toxic component of a type II toxin-antitoxin (TA) system. Its toxic activity is neutralized by cognate antitoxin SpoIISB. Expression in the absence of SpoIISB permits sporulation to stage II, when plasmolysis zones and holes in the peptidoglycan layer are observed, resulting in cell death. Lethal when synthesized during vegetative growth in the absence of SpoIISB. In E.coli both the membrane bound and soluble domain are required in cis for toxin activity. | Putative ATP-dependent DNA helicase; May be involved in the generation of recombinogenic substrates for the subsequent action of RecA. | 0.686 |
| spoIISA | ykaA | BSU12830 | BSU12850 | Two-component apoptosis factor (toxin/antitoxin system); Toxic component of a type II toxin-antitoxin (TA) system. Its toxic activity is neutralized by cognate antitoxin SpoIISB. Expression in the absence of SpoIISB permits sporulation to stage II, when plasmolysis zones and holes in the peptidoglycan layer are observed, resulting in cell death. Lethal when synthesized during vegetative growth in the absence of SpoIISB. In E.coli both the membrane bound and soluble domain are required in cis for toxin activity. | Putative Pit accessory protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative factor; Belongs to the UPF0111 family. | 0.519 |
| spoIISA | ywrE | BSU12830 | BSU36090 | Two-component apoptosis factor (toxin/antitoxin system); Toxic component of a type II toxin-antitoxin (TA) system. Its toxic activity is neutralized by cognate antitoxin SpoIISB. Expression in the absence of SpoIISB permits sporulation to stage II, when plasmolysis zones and holes in the peptidoglycan layer are observed, resulting in cell death. Lethal when synthesized during vegetative growth in the absence of SpoIISB. In E.coli both the membrane bound and soluble domain are required in cis for toxin activity. | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. | 0.560 |
| spoIISA | ywrJ | BSU12830 | BSU36040 | Two-component apoptosis factor (toxin/antitoxin system); Toxic component of a type II toxin-antitoxin (TA) system. Its toxic activity is neutralized by cognate antitoxin SpoIISB. Expression in the absence of SpoIISB permits sporulation to stage II, when plasmolysis zones and holes in the peptidoglycan layer are observed, resulting in cell death. Lethal when synthesized during vegetative growth in the absence of SpoIISB. In E.coli both the membrane bound and soluble domain are required in cis for toxin activity. | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; PubMedId: 14762006. | 0.482 |
| spoIISB | pit | BSU12820 | BSU12840 | Two-component apoptotic control system component B (antitoxin); Antitoxin component of a type II toxin-antitoxin (TA) system. Antitoxin that binds cognate toxin SpoIISA and neutralizes its toxic activity; unlike most antitoxins it does not seem to be highly labile upon expression in E.coli. | Low-affinity inorganic phosphate transporter; Low-affinity inorganic phosphate transport; Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family. Pit subfamily. | 0.516 |
| spoIISB | spoIISA | BSU12820 | BSU12830 | Two-component apoptotic control system component B (antitoxin); Antitoxin component of a type II toxin-antitoxin (TA) system. Antitoxin that binds cognate toxin SpoIISA and neutralizes its toxic activity; unlike most antitoxins it does not seem to be highly labile upon expression in E.coli. | Two-component apoptosis factor (toxin/antitoxin system); Toxic component of a type II toxin-antitoxin (TA) system. Its toxic activity is neutralized by cognate antitoxin SpoIISB. Expression in the absence of SpoIISB permits sporulation to stage II, when plasmolysis zones and holes in the peptidoglycan layer are observed, resulting in cell death. Lethal when synthesized during vegetative growth in the absence of SpoIISB. In E.coli both the membrane bound and soluble domain are required in cis for toxin activity. | 0.999 |
| spoIISB | spoVIF | BSU12820 | BSU11810 | Two-component apoptotic control system component B (antitoxin); Antitoxin component of a type II toxin-antitoxin (TA) system. Antitoxin that binds cognate toxin SpoIISA and neutralizes its toxic activity; unlike most antitoxins it does not seem to be highly labile upon expression in E.coli. | Sporulation-specific protein needed for heat resistance; Transcription factor involved in spore coat assembly and spore resistance. Regulates the transcription of at least cgeA, cotG and cotS. | 0.490 |
| spoIISB | ycgB | BSU12820 | BSU03030 | Two-component apoptotic control system component B (antitoxin); Antitoxin component of a type II toxin-antitoxin (TA) system. Antitoxin that binds cognate toxin SpoIISA and neutralizes its toxic activity; unlike most antitoxins it does not seem to be highly labile upon expression in E.coli. | Putative integral inner membrane protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm: putative membrane component. | 0.762 |
| spoIISB | yitR | BSU12820 | BSU11090 | Two-component apoptotic control system component B (antitoxin); Antitoxin component of a type II toxin-antitoxin (TA) system. Antitoxin that binds cognate toxin SpoIISA and neutralizes its toxic activity; unlike most antitoxins it does not seem to be highly labile upon expression in E.coli. | Hypothetical protein; Evidence 5: No homology to any previously reported sequences. | 0.712 |
| spoIISB | yitS | BSU12820 | BSU11110 | Two-component apoptotic control system component B (antitoxin); Antitoxin component of a type II toxin-antitoxin (TA) system. Antitoxin that binds cognate toxin SpoIISA and neutralizes its toxic activity; unlike most antitoxins it does not seem to be highly labile upon expression in E.coli. | Conserved hypothetical protein; May bind long-chain fatty acids, such as palmitate, and may play a role in lipid transport or fatty acid metabolism. | 0.683 |
| spoIISB | yjcD | BSU12820 | BSU11820 | Two-component apoptotic control system component B (antitoxin); Antitoxin component of a type II toxin-antitoxin (TA) system. Antitoxin that binds cognate toxin SpoIISA and neutralizes its toxic activity; unlike most antitoxins it does not seem to be highly labile upon expression in E.coli. | Putative ATP-dependent DNA helicase; May be involved in the generation of recombinogenic substrates for the subsequent action of RecA. | 0.757 |
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