| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| fnr | hmp | BSU37310 | BSU13040 | Transcriptional regulator (FNR/CAP family); It is involved in the activation of genes necessary for anaerobic respiration. | Flavohemoglobin; Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity). In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. | 0.681 |
| fnr | narG | BSU37310 | BSU37280 | Transcriptional regulator (FNR/CAP family); It is involved in the activation of genes necessary for anaerobic respiration. | Nitrate reductase (alpha subunit); The alpha chain is the actual site of nitrate reduction. | 0.891 |
| fnr | nasD | BSU37310 | BSU03300 | Transcriptional regulator (FNR/CAP family); It is involved in the activation of genes necessary for anaerobic respiration. | Assimilatory nitrite reductase subunit; Required for nitrite assimilation. | 0.796 |
| fnr | nsrR | BSU37310 | BSU09380 | Transcriptional regulator (FNR/CAP family); It is involved in the activation of genes necessary for anaerobic respiration. | NO-dependent activator of the ResDE regulon; Nitric oxide-responsive transcriptional regulator. It represses the expression of flavohemoprotein hmp and the nitrite reductase nasD. Probably plays a role in the up-regulation of the resDE regulon in the presence of nitric oxide. | 0.426 |
| hmp | fnr | BSU13040 | BSU37310 | Flavohemoglobin; Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity). In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. | Transcriptional regulator (FNR/CAP family); It is involved in the activation of genes necessary for anaerobic respiration. | 0.681 |
| hmp | narG | BSU13040 | BSU37280 | Flavohemoglobin; Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity). In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. | Nitrate reductase (alpha subunit); The alpha chain is the actual site of nitrate reduction. | 0.761 |
| hmp | nasB | BSU13040 | BSU03320 | Flavohemoglobin; Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity). In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. | Assimilatory nitrate reductase (electron transfer subunit NasB); Required for nitrate assimilation. | 0.685 |
| hmp | nasD | BSU13040 | BSU03300 | Flavohemoglobin; Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity). In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. | Assimilatory nitrite reductase subunit; Required for nitrite assimilation. | 0.975 |
| hmp | nsrR | BSU13040 | BSU09380 | Flavohemoglobin; Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity). In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. | NO-dependent activator of the ResDE regulon; Nitric oxide-responsive transcriptional regulator. It represses the expression of flavohemoprotein hmp and the nitrite reductase nasD. Probably plays a role in the up-regulation of the resDE regulon in the presence of nitric oxide. | 0.984 |
| hmp | resD | BSU13040 | BSU23120 | Flavohemoglobin; Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity). In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. | Two-component response regulator; Member of the two-component regulatory system ResD/ResE. Required for the expression of resA, ctaA, qcrABC and fnr; activation role in global regulation of aerobic and anaerobic respiration. | 0.835 |
| hmp | resE | BSU13040 | BSU23110 | Flavohemoglobin; Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity). In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. | Two-component sensor histidine kinase; Member of the two-component regulatory system ResD/ResE involved in the global regulation of aerobic and anaerobic respiration. Probably phosphorylates ResD. | 0.831 |
| hmp | sodA | BSU13040 | BSU25020 | Flavohemoglobin; Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity). In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. | Superoxide dismutase; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the iron/manganese superoxide dismutase family. | 0.696 |
| hmp | yflK | BSU13040 | BSU07650 | Flavohemoglobin; Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity). In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. | Putative sulfur carrier; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative carrier. | 0.932 |
| hmp | ykjA | BSU13040 | BSU13060 | Flavohemoglobin; Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity). In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. | 0.730 |
| narG | fnr | BSU37280 | BSU37310 | Nitrate reductase (alpha subunit); The alpha chain is the actual site of nitrate reduction. | Transcriptional regulator (FNR/CAP family); It is involved in the activation of genes necessary for anaerobic respiration. | 0.891 |
| narG | hmp | BSU37280 | BSU13040 | Nitrate reductase (alpha subunit); The alpha chain is the actual site of nitrate reduction. | Flavohemoglobin; Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity). In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. | 0.761 |
| narG | nasB | BSU37280 | BSU03320 | Nitrate reductase (alpha subunit); The alpha chain is the actual site of nitrate reduction. | Assimilatory nitrate reductase (electron transfer subunit NasB); Required for nitrate assimilation. | 0.989 |
| narG | nasD | BSU37280 | BSU03300 | Nitrate reductase (alpha subunit); The alpha chain is the actual site of nitrate reduction. | Assimilatory nitrite reductase subunit; Required for nitrite assimilation. | 0.998 |
| nasB | hmp | BSU03320 | BSU13040 | Assimilatory nitrate reductase (electron transfer subunit NasB); Required for nitrate assimilation. | Flavohemoglobin; Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity). In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. | 0.685 |
| nasB | narG | BSU03320 | BSU37280 | Assimilatory nitrate reductase (electron transfer subunit NasB); Required for nitrate assimilation. | Nitrate reductase (alpha subunit); The alpha chain is the actual site of nitrate reduction. | 0.989 |