STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hmpFlavohemoglobin; Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity). In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (399 aa)    
Predicted Functional Partners:
nsrR
NO-dependent activator of the ResDE regulon; Nitric oxide-responsive transcriptional regulator. It represses the expression of flavohemoprotein hmp and the nitrite reductase nasD. Probably plays a role in the up-regulation of the resDE regulon in the presence of nitric oxide.
 
   
 0.984
nasD
Assimilatory nitrite reductase subunit; Required for nitrite assimilation.
  
  
 0.975
yflK
Putative sulfur carrier; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative carrier.
   
 0.932
resD
Two-component response regulator; Member of the two-component regulatory system ResD/ResE. Required for the expression of resA, ctaA, qcrABC and fnr; activation role in global regulation of aerobic and anaerobic respiration.
   
  
 0.835
resE
Two-component sensor histidine kinase; Member of the two-component regulatory system ResD/ResE involved in the global regulation of aerobic and anaerobic respiration. Probably phosphorylates ResD.
   
  
 0.831
narG
Nitrate reductase (alpha subunit); The alpha chain is the actual site of nitrate reduction.
  
  
 0.761
ykjA
Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function.
   
    0.730
sodA
Superoxide dismutase; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the iron/manganese superoxide dismutase family.
     
 0.696
nasB
Assimilatory nitrate reductase (electron transfer subunit NasB); Required for nitrate assimilation.
  
  
 0.685
fnr
Transcriptional regulator (FNR/CAP family); It is involved in the activation of genes necessary for anaerobic respiration.
  
  
 0.681
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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