node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
abrB | kinB | BSU00370 | BSU31450 | Transcriptional regulator for transition state genes; Ambiactive repressor and activator of the transcription of genes expressed during the transition state between vegetative growth and the onset of stationary phase and sporulation. It controls the expression of genes spovG and tycA. AbrB binds to the tycA promoter region at two A- and T-rich sites, it may be the sole repressor of tycA transcription; To B.subtilis Abh and SpoVT. | Two-component sensor histidine kinase; Phosphorylates the sporulation-regulatory proteins spo0A and spo0F. Spo0F is required for the KinB activity. | 0.751 |
abrB | kinD | BSU00370 | BSU13660 | Transcriptional regulator for transition state genes; Ambiactive repressor and activator of the transcription of genes expressed during the transition state between vegetative growth and the onset of stationary phase and sporulation. It controls the expression of genes spovG and tycA. AbrB binds to the tycA promoter region at two A- and T-rich sites, it may be the sole repressor of tycA transcription; To B.subtilis Abh and SpoVT. | Histidine kinase phosphorylating Spo0A; Phosphorylates the sporulation-regulatory protein spo0F and, to a minor extent, is responsible for heterogeneous expression of spo0A during logarithmical growth. Also phosphorylates spo0A under biofilm growth conditions. | 0.565 |
abrB | kinE | BSU00370 | BSU13530 | Transcriptional regulator for transition state genes; Ambiactive repressor and activator of the transcription of genes expressed during the transition state between vegetative growth and the onset of stationary phase and sporulation. It controls the expression of genes spovG and tycA. AbrB binds to the tycA promoter region at two A- and T-rich sites, it may be the sole repressor of tycA transcription; To B.subtilis Abh and SpoVT. | Two-component sensor histidine kinase; Phosphorylates the sporulation-regulatory protein spo0A under biofilm growth conditions. Also able to weakly phosphorylate spo0F. | 0.680 |
abrB | resD | BSU00370 | BSU23120 | Transcriptional regulator for transition state genes; Ambiactive repressor and activator of the transcription of genes expressed during the transition state between vegetative growth and the onset of stationary phase and sporulation. It controls the expression of genes spovG and tycA. AbrB binds to the tycA promoter region at two A- and T-rich sites, it may be the sole repressor of tycA transcription; To B.subtilis Abh and SpoVT. | Two-component response regulator; Member of the two-component regulatory system ResD/ResE. Required for the expression of resA, ctaA, qcrABC and fnr; activation role in global regulation of aerobic and anaerobic respiration. | 0.680 |
abrB | spo0A | BSU00370 | BSU24220 | Transcriptional regulator for transition state genes; Ambiactive repressor and activator of the transcription of genes expressed during the transition state between vegetative growth and the onset of stationary phase and sporulation. It controls the expression of genes spovG and tycA. AbrB binds to the tycA promoter region at two A- and T-rich sites, it may be the sole repressor of tycA transcription; To B.subtilis Abh and SpoVT. | Response regulator; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with Spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. Repressor of abrB, activator of the spoIIa operon. Binds the DNA sequence 5'-TGNCGAA-3' (0A box). | 0.995 |
abrB | spo0B | BSU00370 | BSU27930 | Transcriptional regulator for transition state genes; Ambiactive repressor and activator of the transcription of genes expressed during the transition state between vegetative growth and the onset of stationary phase and sporulation. It controls the expression of genes spovG and tycA. AbrB binds to the tycA promoter region at two A- and T-rich sites, it may be the sole repressor of tycA transcription; To B.subtilis Abh and SpoVT. | Sporulation initiation phosphotransferase; Key element in the phosphorelay regulating sporulation initiation. Acts on spo0A. Mediates reversible phosphoryl transfer from spo0F to spo0A. | 0.767 |
abrB | spo0E | BSU00370 | BSU13640 | Transcriptional regulator for transition state genes; Ambiactive repressor and activator of the transcription of genes expressed during the transition state between vegetative growth and the onset of stationary phase and sporulation. It controls the expression of genes spovG and tycA. AbrB binds to the tycA promoter region at two A- and T-rich sites, it may be the sole repressor of tycA transcription; To B.subtilis Abh and SpoVT. | Negative regulatory phosphatase acting on Spo0A-P (sporulation); Aspartyl-phosphate phosphatase which specifically dephosphorylates the sporulation transcription factor Spo0A-P and negatively regulates the sporulation initiation pathway in order to control the proper timing of sporulation. Belongs to the spo0E family. | 0.759 |
abrB | spo0F | BSU00370 | BSU37130 | Transcriptional regulator for transition state genes; Ambiactive repressor and activator of the transcription of genes expressed during the transition state between vegetative growth and the onset of stationary phase and sporulation. It controls the expression of genes spovG and tycA. AbrB binds to the tycA promoter region at two A- and T-rich sites, it may be the sole repressor of tycA transcription; To B.subtilis Abh and SpoVT. | Two-component response regulator; Key element in the phosphorelay regulating sporulation initiation. Phosphorylation of spo0B during sporulation initiation. | 0.848 |
kinB | abrB | BSU31450 | BSU00370 | Two-component sensor histidine kinase; Phosphorylates the sporulation-regulatory proteins spo0A and spo0F. Spo0F is required for the KinB activity. | Transcriptional regulator for transition state genes; Ambiactive repressor and activator of the transcription of genes expressed during the transition state between vegetative growth and the onset of stationary phase and sporulation. It controls the expression of genes spovG and tycA. AbrB binds to the tycA promoter region at two A- and T-rich sites, it may be the sole repressor of tycA transcription; To B.subtilis Abh and SpoVT. | 0.751 |
kinB | kinD | BSU31450 | BSU13660 | Two-component sensor histidine kinase; Phosphorylates the sporulation-regulatory proteins spo0A and spo0F. Spo0F is required for the KinB activity. | Histidine kinase phosphorylating Spo0A; Phosphorylates the sporulation-regulatory protein spo0F and, to a minor extent, is responsible for heterogeneous expression of spo0A during logarithmical growth. Also phosphorylates spo0A under biofilm growth conditions. | 0.738 |
kinB | kinE | BSU31450 | BSU13530 | Two-component sensor histidine kinase; Phosphorylates the sporulation-regulatory proteins spo0A and spo0F. Spo0F is required for the KinB activity. | Two-component sensor histidine kinase; Phosphorylates the sporulation-regulatory protein spo0A under biofilm growth conditions. Also able to weakly phosphorylate spo0F. | 0.699 |
kinB | phoP | BSU31450 | BSU29110 | Two-component sensor histidine kinase; Phosphorylates the sporulation-regulatory proteins spo0A and spo0F. Spo0F is required for the KinB activity. | Two-component response regulator; Member of the two-component regulatory system PhoP/PhoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase. | 0.853 |
kinB | resD | BSU31450 | BSU23120 | Two-component sensor histidine kinase; Phosphorylates the sporulation-regulatory proteins spo0A and spo0F. Spo0F is required for the KinB activity. | Two-component response regulator; Member of the two-component regulatory system ResD/ResE. Required for the expression of resA, ctaA, qcrABC and fnr; activation role in global regulation of aerobic and anaerobic respiration. | 0.886 |
kinB | spo0A | BSU31450 | BSU24220 | Two-component sensor histidine kinase; Phosphorylates the sporulation-regulatory proteins spo0A and spo0F. Spo0F is required for the KinB activity. | Response regulator; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with Spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. Repressor of abrB, activator of the spoIIa operon. Binds the DNA sequence 5'-TGNCGAA-3' (0A box). | 0.976 |
kinB | spo0B | BSU31450 | BSU27930 | Two-component sensor histidine kinase; Phosphorylates the sporulation-regulatory proteins spo0A and spo0F. Spo0F is required for the KinB activity. | Sporulation initiation phosphotransferase; Key element in the phosphorelay regulating sporulation initiation. Acts on spo0A. Mediates reversible phosphoryl transfer from spo0F to spo0A. | 0.919 |
kinB | spo0E | BSU31450 | BSU13640 | Two-component sensor histidine kinase; Phosphorylates the sporulation-regulatory proteins spo0A and spo0F. Spo0F is required for the KinB activity. | Negative regulatory phosphatase acting on Spo0A-P (sporulation); Aspartyl-phosphate phosphatase which specifically dephosphorylates the sporulation transcription factor Spo0A-P and negatively regulates the sporulation initiation pathway in order to control the proper timing of sporulation. Belongs to the spo0E family. | 0.681 |
kinB | spo0F | BSU31450 | BSU37130 | Two-component sensor histidine kinase; Phosphorylates the sporulation-regulatory proteins spo0A and spo0F. Spo0F is required for the KinB activity. | Two-component response regulator; Key element in the phosphorelay regulating sporulation initiation. Phosphorylation of spo0B during sporulation initiation. | 0.998 |
kinD | abrB | BSU13660 | BSU00370 | Histidine kinase phosphorylating Spo0A; Phosphorylates the sporulation-regulatory protein spo0F and, to a minor extent, is responsible for heterogeneous expression of spo0A during logarithmical growth. Also phosphorylates spo0A under biofilm growth conditions. | Transcriptional regulator for transition state genes; Ambiactive repressor and activator of the transcription of genes expressed during the transition state between vegetative growth and the onset of stationary phase and sporulation. It controls the expression of genes spovG and tycA. AbrB binds to the tycA promoter region at two A- and T-rich sites, it may be the sole repressor of tycA transcription; To B.subtilis Abh and SpoVT. | 0.565 |
kinD | kinB | BSU13660 | BSU31450 | Histidine kinase phosphorylating Spo0A; Phosphorylates the sporulation-regulatory protein spo0F and, to a minor extent, is responsible for heterogeneous expression of spo0A during logarithmical growth. Also phosphorylates spo0A under biofilm growth conditions. | Two-component sensor histidine kinase; Phosphorylates the sporulation-regulatory proteins spo0A and spo0F. Spo0F is required for the KinB activity. | 0.738 |
kinD | kinE | BSU13660 | BSU13530 | Histidine kinase phosphorylating Spo0A; Phosphorylates the sporulation-regulatory protein spo0F and, to a minor extent, is responsible for heterogeneous expression of spo0A during logarithmical growth. Also phosphorylates spo0A under biofilm growth conditions. | Two-component sensor histidine kinase; Phosphorylates the sporulation-regulatory protein spo0A under biofilm growth conditions. Also able to weakly phosphorylate spo0F. | 0.641 |