node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
folEA | folEB | BSU22780 | BSU03340 | GTP cyclohydrolase I; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the GTP cyclohydrolase I family. | GTP cyclohydrolase I; Converts GTP to 7,8-dihydroneopterin triphosphate. Belongs to the GTP cyclohydrolase IV family. | 0.992 |
folEA | phoB | BSU22780 | BSU05740 | GTP cyclohydrolase I; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the GTP cyclohydrolase I family. | Alkaline phosphatase III; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the alkaline phosphatase family. | 0.901 |
folEA | phoD | BSU22780 | BSU02620 | GTP cyclohydrolase I; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the GTP cyclohydrolase I family. | Alkaline phosphatase D; Evidence 1a: Function experimentally demonstrated in the studied strain; enzyme. | 0.926 |
folEA | queA | BSU22780 | BSU27720 | GTP cyclohydrolase I; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the GTP cyclohydrolase I family. | S-adenosylmethionine tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | 0.727 |
folEA | queC | BSU22780 | BSU13720 | GTP cyclohydrolase I; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the GTP cyclohydrolase I family. | Pre-queuosine 0 synthase; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Uses ammonia as nitrogen donor. | 0.831 |
folEA | queD | BSU22780 | BSU13730 | GTP cyclohydrolase I; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the GTP cyclohydrolase I family. | 6-carboxy-5,6,7,8-tetrahydropterin synthase; Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde. Belongs to the PTPS family. QueD subfamily. | 0.998 |
folEA | queE | BSU22780 | BSU13740 | GTP cyclohydrolase I; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the GTP cyclohydrolase I family. | 7-carboxy-7-deazaguanine synthase; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.940 |
folEA | queF | BSU22780 | BSU13750 | GTP cyclohydrolase I; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the GTP cyclohydrolase I family. | NADPH-dependent 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1), a late step in the queuosine pathway; Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | 0.881 |
folEA | queG | BSU22780 | BSU08910 | GTP cyclohydrolase I; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the GTP cyclohydrolase I family. | Epoxyqueuosine reductase; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). | 0.775 |
folEA | tgt | BSU22780 | BSU27710 | GTP cyclohydrolase I; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the GTP cyclohydrolase I family. | tRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...] | 0.745 |
folEB | folEA | BSU03340 | BSU22780 | GTP cyclohydrolase I; Converts GTP to 7,8-dihydroneopterin triphosphate. Belongs to the GTP cyclohydrolase IV family. | GTP cyclohydrolase I; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the GTP cyclohydrolase I family. | 0.992 |
folEB | phoB | BSU03340 | BSU05740 | GTP cyclohydrolase I; Converts GTP to 7,8-dihydroneopterin triphosphate. Belongs to the GTP cyclohydrolase IV family. | Alkaline phosphatase III; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the alkaline phosphatase family. | 0.900 |
folEB | phoD | BSU03340 | BSU02620 | GTP cyclohydrolase I; Converts GTP to 7,8-dihydroneopterin triphosphate. Belongs to the GTP cyclohydrolase IV family. | Alkaline phosphatase D; Evidence 1a: Function experimentally demonstrated in the studied strain; enzyme. | 0.900 |
folEB | queD | BSU03340 | BSU13730 | GTP cyclohydrolase I; Converts GTP to 7,8-dihydroneopterin triphosphate. Belongs to the GTP cyclohydrolase IV family. | 6-carboxy-5,6,7,8-tetrahydropterin synthase; Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde. Belongs to the PTPS family. QueD subfamily. | 0.944 |
phoB | folEA | BSU05740 | BSU22780 | Alkaline phosphatase III; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the alkaline phosphatase family. | GTP cyclohydrolase I; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the GTP cyclohydrolase I family. | 0.901 |
phoB | folEB | BSU05740 | BSU03340 | Alkaline phosphatase III; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the alkaline phosphatase family. | GTP cyclohydrolase I; Converts GTP to 7,8-dihydroneopterin triphosphate. Belongs to the GTP cyclohydrolase IV family. | 0.900 |
phoB | phoD | BSU05740 | BSU02620 | Alkaline phosphatase III; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the alkaline phosphatase family. | Alkaline phosphatase D; Evidence 1a: Function experimentally demonstrated in the studied strain; enzyme. | 0.988 |
phoB | queD | BSU05740 | BSU13730 | Alkaline phosphatase III; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the alkaline phosphatase family. | 6-carboxy-5,6,7,8-tetrahydropterin synthase; Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde. Belongs to the PTPS family. QueD subfamily. | 0.900 |
phoD | folEA | BSU02620 | BSU22780 | Alkaline phosphatase D; Evidence 1a: Function experimentally demonstrated in the studied strain; enzyme. | GTP cyclohydrolase I; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the GTP cyclohydrolase I family. | 0.926 |
phoD | folEB | BSU02620 | BSU03340 | Alkaline phosphatase D; Evidence 1a: Function experimentally demonstrated in the studied strain; enzyme. | GTP cyclohydrolase I; Converts GTP to 7,8-dihydroneopterin triphosphate. Belongs to the GTP cyclohydrolase IV family. | 0.900 |