STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yknWHypothetical protein; Part of an unusual four-component transporter, which is required for protection against the killing factor SdpC (sporulation- delaying protein). Has a role in the assembly of the YknXYZ complex (231 aa)    
Predicted Functional Partners:
yknX
Hlyd family secretion protein; Part of an unusual four-component transporter, which is required for protection against the killing factor SdpC (sporulation- delaying protein)
 
   
 0.997
yknZ
Putative abc transport system permease protein; Part of an unusual four-component transporter, which is required for protection against the killing factor SdpC (sporulation- delaying protein)
 
   
 0.996
yknY
Putative abc transport system atp-binding protein; Part of an unusual four-component transporter, which is required for protection against the killing factor SdpC (sporulation- delaying protein)
 
   
 0.995
spbC
Killing factor sdpc; Produces a 42-residue extracellular sporulation delaying protein (SDP) that collapses the proton motive force (probably both the membrane potential and pH gradient) across the cell membrane, which leads to autolysis; may form a proton channel . Induces the lysis of other B.subtilis cells that have not entered the sporulation pathway, inducing cannibalism to provide a source of nutrients to support sporulation, and at the same time delaying commitment to the energetically expensive and irreversible onset of sporulation . Addition of SDP to liquid cultures halts grow [...]
      
 0.902
yknV
Uncharacterized ABC transporter ATP-binding protein YknV; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter
     
 0.808
yknU
Uncharacterized ABC transporter ATP-binding protein YknU; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter
     
 0.802
sdpI
Integral membrane regulator of autophagy; Immunity protein that provides protection for the cell against the toxic effects of SDP, its own SdpC-derived killing factor, and that functions as a receptor/signal transduction protein as well. Once SDP accumulates in the extracellular milieu, SdpI binds to SDP, causing sequestration of SdpR at the bacterial membrane
      
 0.730
cca
Trna nucleotidyltransferase (cca-adding enzyme); Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Has no poly(A) polymerase activity
      
 0.722
ygaO
Uncharacterized lipoprotein YgaO; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm: putative membrane component
  
     0.721
yfiG
Putative metabolite transport protein YfiG; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter
      
 0.713
Your Current Organism:
Bacillus subtilis
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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