STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
kinCTwo-component sensor histidine kinase; Phosphorylates the sporulation-regulatory protein spo0A. (428 aa)    
Predicted Functional Partners:
spo0F
Two-component response regulator; Key element in the phosphorelay regulating sporulation initiation. Phosphorylation of spo0B during sporulation initiation.
  
  
 0.998
spo0A
Response regulator; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with Spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. Repressor of abrB, activator of the spoIIa operon. Binds the DNA sequence 5'-TGNCGAA-3' (0A box).
  
  
 0.994
tapA
Lipoprotein for biofilm formation; Required for biofilm formation. Required for the proper anchoring and polymerization of TasA amyloid fibers at the cell surface. Is also a minor component of TasA fibers.
   
  
 0.913
spo0B
Sporulation initiation phosphotransferase; Key element in the phosphorelay regulating sporulation initiation. Acts on spo0A. Mediates reversible phosphoryl transfer from spo0F to spo0A.
   
  
 0.906
ycbM
Two-component sensor histidine kinase [YcbL]; Member of the two-component regulatory system YcbM/YcbL. Probably activates YcbL by phosphorylation.
 
    0.888
ytvA
Blue light GTP-binding receptor; Exhibits the same spectroscopical features and blue-light induced photochemistry as plants phototropins, with the reversible formation of a blue-shifted photoproduct, assigned to an FMN-cysteine thiol adduct. Although it is a positive regulator in the activation of the environmental signaling branch of the general stress transcription factor sigma-B, its precise role is undetermined.
 
    
0.881
epsA
Modulator of protein tyrosine kinase EpsB; Evidence 2b: Function of strongly homologous gene; regulator.
      
 0.848
sipW
Type I signal peptidase; Required for the cleavage of the signal sequence of TasA and TapA, which are involved in biofilm formation. Belongs to the peptidase S26B family.
      
 0.846
cheR
Methyl-accepting chemotaxis proteins (MCPs) methyltransferase; Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP. CheR is responsible for the chemotactic adaptation to repellents.
 
 
    0.837
ykqA
Conserved hypothetical protein; Putative gamma-glutamylcyclotransferase.
  
    0.813
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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