STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ylaCRNA polymerase ECF-type sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor contributes to oxidative stress resistance. (173 aa)    
Predicted Functional Partners:
ylaD
anti-YlaC sigma factor; Anti-sigma factor for YlaC; Belongs to the zinc-associated anti-sigma factor (ZAS) superfamily.
  
  
 0.985
ylaB
Hypothetical protein; Evidence 5: No homology to any previously reported sequences; PubMedId: 16501307.
  
  
 0.983
ylaA
Hypothetical protein; Evidence 5: No homology to any previously reported sequences; PubMedId: 16501307.
  
  
 0.979
sigY
RNA polymerase ECF (extracytoplasmic function)-type sigma factor (sigma-Y); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Positively regulates the expression of the sigY-yxlCDEFG operon upon nitrogen starvation. Also positively regulates ybgB.
  
   
 0.964
yxlC
sigma-Y antisigma factor; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type r: regulator.
      
 0.631
rpoC
RNA polymerase (beta' subunit); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.582
yvcR
Putative ABC transporter (ATP-binding protein); Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter; Belongs to the ABC transporter superfamily.
   
  
 0.574
rpoB
RNA polymerase (beta subunit); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.532
ysmA
Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function.
     
 0.512
sigZ
RNA polymerase ECF(extracytoplasmic function)-type sigma factor (sigma-Z); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
  
  
0.501
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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