Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ylaDanti-YlaC sigma factor; Anti-sigma factor for YlaC; Belongs to the zinc-associated anti-sigma factor (ZAS) superfamily. (97 aa)    
Predicted Functional Partners:
ylaC
RNA polymerase ECF-type sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor contributes to oxidative stress resistance.
  
  
 0.986
ylaB
Hypothetical protein; Evidence 5: No homology to any previously reported sequences; PubMedId: 16501307.
  
  
 0.948
ylaA
Hypothetical protein; Evidence 5: No homology to any previously reported sequences; PubMedId: 16501307.
  
  
 0.940
dctB
C4-dicarboxylate binding protein; Part of the binding-protein-dependent transport system for uptake of C4-dicarboxylates. Responsible for growth on fumarate and succinate but not malate. Is not directly involved in C4-dicarboxylate uptake, but plays a sensory role in the DctS/DctR two-component system which regulates the expression of the dctA C4-dicarboxylate transporter; Belongs to the bacterial solute-binding protein 7 family.
   
 
 0.740
yxlC
sigma-Y antisigma factor; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type r: regulator.
      
 0.718
sigZ
RNA polymerase ECF(extracytoplasmic function)-type sigma factor (sigma-Z); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
  
  
 0.601
sigY
RNA polymerase ECF (extracytoplasmic function)-type sigma factor (sigma-Y); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Positively regulates the expression of the sigY-yxlCDEFG operon upon nitrogen starvation. Also positively regulates ybgB.
     
 0.471
sigV
RNA polymerase ECF(extracytoplasmic function)-type sigma factor (sigma(V)); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Positively regulates the expression of proteins involved in stress responses against bacitracin, paraquat and tellurite. Belongs to the sigma-70 factor family. ECF subfamily.
  
  
 0.433
nprE
Extracellular neutral metalloprotease; Extracellular zinc metalloprotease; Belongs to the peptidase M4 family.
       0.419
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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