node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
carB | pyrAA | BSU11240 | BSU15510 | Arginine-specific carbamoyl-phosphate synthetase (large subunit); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the CarB family. | Pyrimidine-specific carbamoyl-phosphate synthetase (small subunit, glutaminase subunit); Evidence 2b: Function of strongly homologous gene; enzyme. | 0.999 |
carB | pyrAB | BSU11240 | BSU15520 | Arginine-specific carbamoyl-phosphate synthetase (large subunit); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the CarB family. | Pyrimidine-specific carbamoyl-phosphate synthetase (large subunit); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the CarB family. | 0.904 |
carB | pyrB | BSU11240 | BSU15490 | Arginine-specific carbamoyl-phosphate synthetase (large subunit); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the CarB family. | Aspartate carbamoyltransferase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. | 0.999 |
carB | pyrC | BSU11240 | BSU15500 | Arginine-specific carbamoyl-phosphate synthetase (large subunit); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the CarB family. | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. | 0.997 |
carB | pyrD | BSU11240 | BSU15540 | Arginine-specific carbamoyl-phosphate synthetase (large subunit); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the CarB family. | Dihydroorotate dehydrogenase (catalytic subunit); Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor. | 0.976 |
carB | pyrE | BSU11240 | BSU15560 | Arginine-specific carbamoyl-phosphate synthetase (large subunit); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the CarB family. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.957 |
carB | pyrF | BSU11240 | BSU15550 | Arginine-specific carbamoyl-phosphate synthetase (large subunit); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the CarB family. | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.952 |
carB | pyrK | BSU11240 | BSU15530 | Arginine-specific carbamoyl-phosphate synthetase (large subunit); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the CarB family. | Dihydroorotate dehydrogenase (electron transfer subunit); Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD subunit to the ultimate electron acceptor NAD(+); Belongs to the PyrK family. | 0.920 |
carB | pyrP | BSU11240 | BSU15480 | Arginine-specific carbamoyl-phosphate synthetase (large subunit); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the CarB family. | Uracil permease; Transport of uracil in the cell; Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily. | 0.782 |
carB | pyrR | BSU11240 | BSU15470 | Arginine-specific carbamoyl-phosphate synthetase (large subunit); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the CarB family. | Transcriptional attenuator and uracil phosphoribosyltransferase activity; Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes; Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. | 0.915 |
pyrAA | carB | BSU15510 | BSU11240 | Pyrimidine-specific carbamoyl-phosphate synthetase (small subunit, glutaminase subunit); Evidence 2b: Function of strongly homologous gene; enzyme. | Arginine-specific carbamoyl-phosphate synthetase (large subunit); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the CarB family. | 0.999 |
pyrAA | pyrAB | BSU15510 | BSU15520 | Pyrimidine-specific carbamoyl-phosphate synthetase (small subunit, glutaminase subunit); Evidence 2b: Function of strongly homologous gene; enzyme. | Pyrimidine-specific carbamoyl-phosphate synthetase (large subunit); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the CarB family. | 0.999 |
pyrAA | pyrB | BSU15510 | BSU15490 | Pyrimidine-specific carbamoyl-phosphate synthetase (small subunit, glutaminase subunit); Evidence 2b: Function of strongly homologous gene; enzyme. | Aspartate carbamoyltransferase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. | 0.999 |
pyrAA | pyrC | BSU15510 | BSU15500 | Pyrimidine-specific carbamoyl-phosphate synthetase (small subunit, glutaminase subunit); Evidence 2b: Function of strongly homologous gene; enzyme. | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. | 0.999 |
pyrAA | pyrD | BSU15510 | BSU15540 | Pyrimidine-specific carbamoyl-phosphate synthetase (small subunit, glutaminase subunit); Evidence 2b: Function of strongly homologous gene; enzyme. | Dihydroorotate dehydrogenase (catalytic subunit); Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor. | 0.999 |
pyrAA | pyrE | BSU15510 | BSU15560 | Pyrimidine-specific carbamoyl-phosphate synthetase (small subunit, glutaminase subunit); Evidence 2b: Function of strongly homologous gene; enzyme. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.999 |
pyrAA | pyrF | BSU15510 | BSU15550 | Pyrimidine-specific carbamoyl-phosphate synthetase (small subunit, glutaminase subunit); Evidence 2b: Function of strongly homologous gene; enzyme. | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.999 |
pyrAA | pyrK | BSU15510 | BSU15530 | Pyrimidine-specific carbamoyl-phosphate synthetase (small subunit, glutaminase subunit); Evidence 2b: Function of strongly homologous gene; enzyme. | Dihydroorotate dehydrogenase (electron transfer subunit); Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD subunit to the ultimate electron acceptor NAD(+); Belongs to the PyrK family. | 0.999 |
pyrAA | pyrP | BSU15510 | BSU15480 | Pyrimidine-specific carbamoyl-phosphate synthetase (small subunit, glutaminase subunit); Evidence 2b: Function of strongly homologous gene; enzyme. | Uracil permease; Transport of uracil in the cell; Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily. | 0.993 |
pyrAA | pyrR | BSU15510 | BSU15470 | Pyrimidine-specific carbamoyl-phosphate synthetase (small subunit, glutaminase subunit); Evidence 2b: Function of strongly homologous gene; enzyme. | Transcriptional attenuator and uracil phosphoribosyltransferase activity; Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes; Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. | 0.966 |