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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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[Homology]
Score
yloBP-type calcium transport ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (890 aa)    
Predicted Functional Partners:
yfkE
Putative H+/Ca2+ antiporter; Ca(+)/H(+) antiporter that extrudes calcium in exchange for external protons. Does not transport sodium or potassium. Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. Cation/proton exchanger (CAX) subfamily.
 
 
 0.943
yfjQ
Putative divalent cation transport protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter.
  
  
 0.921
yloA
Putative persistent RNA/DNA binding protein; Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. Selectively binds tRNA(Ala)(UGC), which is presumably the sole source of tRNA(Ala) used for Ala tailing directed by this protein. May add between 1 and at least 8 Ala residues; detection of the Ala tail requires either deletion of clpP or its inhibition. Binds to 50S ribosomal [...]
   
 
 0.809
yqxL
Putative CorA-type Mg(2+) transporter; Mediates influx of magnesium ions. Alternates between open and closed states. Activated by low cytoplasmic Mg(2+) levels. Inactive when cytoplasmic Mg(2+) levels are high. May also mediate uptake of Co(2+).
 
  
 0.729
yloC
Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; Belongs to the UPF0701 family.
       0.710
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
   
 
 0.699
rpoZ
Omega subunit of RNA polymerase; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).
     
 0.675
sapB
Membrane component; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type ph: phenotype.
 
 
 0.656
ylzA
Conserved hypothetical protein; Regulates the biosynthesis of the extracellular matrix and the biofilm formation. Activates the transcription of the matrix biosynthesis operons eps and tapA-sipW- tasA. Also activates expression of the opuA operon, involved in osmoprotection. Acts by binding specifically to the promoter region of the target genes. Acts in parallel to the pathway that governs SinR derepression. Required for endosporulation.
       0.631
spoIVFB
Membrane metalloprotease; Implicated in the coupling of mother cell to forespore gene expression. Required for spore formation. Processes the pro-sigma K factor.
 
    0.610
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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