node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
apt | gmk | BSU27610 | BSU15680 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.968 |
apt | guaA | BSU27610 | BSU06360 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP synthetase; Catalyzes the synthesis of GMP from XMP. | 0.993 |
apt | hprT | BSU27610 | BSU00680 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Hypoxanthine-guanine phosphoribosyltransferase; Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; Product type e: enzyme. | 0.987 |
apt | rsh | BSU27610 | BSU27600 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GTP pyrophosphokinase (RelA/SpoT); In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp, it is probably the hydrolysis activity that is required for optimal growth (Probable); Belongs to the RelA/SpoT family. | 0.579 |
apt | xpt | BSU27610 | BSU22070 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so that it can be reused for RNA or DNA synthesis; Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily. | 0.967 |
glpF | gmk | BSU09280 | BSU15680 | Glycerol permease; Glycerol enters the cell via the glycerol diffusion facilitator protein. This membrane protein facilitates the movement of glycerol across the cytoplasmic membrane; Belongs to the MIP/aquaporin (TC 1.A.8) family. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.956 |
glpF | tpiA | BSU09280 | BSU33920 | Glycerol permease; Glycerol enters the cell via the glycerol diffusion facilitator protein. This membrane protein facilitates the movement of glycerol across the cytoplasmic membrane; Belongs to the MIP/aquaporin (TC 1.A.8) family. | Triose phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. | 0.939 |
gmk | apt | BSU15680 | BSU27610 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.968 |
gmk | glpF | BSU15680 | BSU09280 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Glycerol permease; Glycerol enters the cell via the glycerol diffusion facilitator protein. This membrane protein facilitates the movement of glycerol across the cytoplasmic membrane; Belongs to the MIP/aquaporin (TC 1.A.8) family. | 0.956 |
gmk | guaA | BSU15680 | BSU06360 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | GMP synthetase; Catalyzes the synthesis of GMP from XMP. | 0.987 |
gmk | hprT | BSU15680 | BSU00680 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Hypoxanthine-guanine phosphoribosyltransferase; Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; Product type e: enzyme. | 0.978 |
gmk | pyk | BSU15680 | BSU29180 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Pyruvate kinase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; In the C-terminal section; belongs to the PEP-utilizing enzyme family. | 0.953 |
gmk | rpoZ | BSU15680 | BSU15690 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Omega subunit of RNA polymerase; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity). | 0.996 |
gmk | rsh | BSU15680 | BSU27600 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | GTP pyrophosphokinase (RelA/SpoT); In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp, it is probably the hydrolysis activity that is required for optimal growth (Probable); Belongs to the RelA/SpoT family. | 0.952 |
gmk | tpiA | BSU15680 | BSU33920 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Triose phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. | 0.958 |
gmk | xpt | BSU15680 | BSU22070 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so that it can be reused for RNA or DNA synthesis; Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily. | 0.961 |
gmk | ylzA | BSU15680 | BSU15670 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Conserved hypothetical protein; Regulates the biosynthesis of the extracellular matrix and the biofilm formation. Activates the transcription of the matrix biosynthesis operons eps and tapA-sipW- tasA. Also activates expression of the opuA operon, involved in osmoprotection. Acts by binding specifically to the promoter region of the target genes. Acts in parallel to the pathway that governs SinR derepression. Required for endosporulation. | 0.978 |
guaA | apt | BSU06360 | BSU27610 | GMP synthetase; Catalyzes the synthesis of GMP from XMP. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.993 |
guaA | gmk | BSU06360 | BSU15680 | GMP synthetase; Catalyzes the synthesis of GMP from XMP. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.987 |
guaA | hprT | BSU06360 | BSU00680 | GMP synthetase; Catalyzes the synthesis of GMP from XMP. | Hypoxanthine-guanine phosphoribosyltransferase; Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; Product type e: enzyme. | 0.986 |