STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pksAPutative transcriptional regulator; Transcriptional regulation of the polyketide synthase operon. (205 aa)    
Predicted Functional Partners:
ymcC
Putative integral inner membrane protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm: putative membrane component.
 
    0.911
kduI
4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase, 5-keto-4-deoxyuronate isomerase; Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate.
   
    0.755
pksB
Putative hydrolase; Probably involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism; Belongs to the metallo-beta-lactamase superfamily.
  
    0.528
comN
Post-transcriptional regulator; Required for post-transcription initiation control of the comE operon. Promotes the accumulation of its target comE mRNA to septal and polar sites.
  
    0.505
yfhF
Putative nucleotide binding protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf: putative factor; Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.
  
    0.485
mntR
Transcriptional regulator (DtxR family); Central regulator of manganese homeostasis that regulates the expression of both manganese uptake and efflux systems. In the presence of high levels of manganese, it mediates repression of the manganese uptake systems MntH and MntABCD and activation of the efflux systems MneP and MneS. Binds with high affinity to the regulatory regions of its target genes. The manganese concentration required for activation of efflux is higher than that for repression of uptake ; Belongs to the DtxR/MntR family.
   
    0.478
yqeB
Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function.
  
     0.478
yvbH
Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function.
  
    0.478
mntC
Manganese ABC transporter (permease); Probably part of the ABC transporter complex MntABCD involved in manganese import. Probably responsible for the translocation of the substrate across the membrane; Belongs to the ABC-3 integral membrane protein family.
   
    0.463
tmrB
ATP-binding tunicamycin resistance protein; Involved in the resistance to tunicamycin. Binds ATP.
  
    0.445
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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