STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
spoVKMother cell sporulation ATPase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type cp: cell process. (322 aa)    
Predicted Functional Partners:
acuC
Protein deacetylase; Role in growth and sporulation on acetoin or butanediol. Involved in the breakdown of these compounds used as a carbon source; Belongs to the histone deacetylase family.
   
 0.905
dnaN
DNA polymerase III (beta subunit); Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation o [...]
  
 
 0.863
holB
DNA polymerase III delta' subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria.
   
 0.762
htpG
Class III heat-shock protein (molecular chaperone); Molecular chaperone. Has ATPase activity.
   
 0.717
glpK
Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family.
   
  0.707
spoIVB
Regulatory membrane-associated serine protease; Plays a central role in the sigma-K checkpoint which coordinates gene expression during the later stages of spore formation. The protease is activated by trans cleavage of the zymogen precursor producing SpoIVB-45 kDa. This undergoes further trimming by cis cleavage to form SpoIVB-43 kDa and SpoIVB-42 kDa. The protease then cleaves the C-terminus of the SpoIVFA metalloprotease activating the latter.
 
  
 0.644
yqfC
Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; PubMedId: 12662922.
  
  
 0.638
spoIIID
Transcriptional regulator; This protein regulates the transcription of sigK, which encodes mother cell chamber RNA polymerase sigma-factor (sigma K).
  
  
 0.622
ylbJ
Putative factor required for spore cortex formation; Required for spore cortex formation.
  
  
 0.612
ymxH
Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; Belongs to the YlmC/YmxH family.
 
    0.607
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
Server load: low (28%) [HD]