STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ynaEConserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (213 aa)    
Predicted Functional Partners:
yktD
Conserved hypothetical protein; May be involved in polyketide synthesis.
      
 0.919
ynaF
Hypothetical protein; Evidence 5: No homology to any previously reported sequences.
  
    0.818
ynaG
Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function.
  
    0.729
ribC
Bifunctional riboflavin kinase FAD synthase; Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD.
      
 0.680
ynaI
Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; To L.lactis TrpF C-terminal region.
  
    0.602
thiF
Adenylate transferase and sulfur transferase (thiamine biosynthesis); Catalyzes the adenylation by ATP of the carboxyl group of the C-terminal glycine of sulfur carrier protein ThiS; Belongs to the HesA/MoeB/ThiF family.
      
 0.572
rttL
Phage toxin ribonuclease; Toxic component of a type II toxin-antitoxin (TA) system. The C-terminus (residues 449-600) has RNase activity, and inhibits growth upon expression in E.coli. In vitro RNase activity and in vivo growth inhibition are neutralized by cognate antitoxin YobK, but not by antitoxins specific to other toxins with the LXG domain.
   
    0.501
mmsA
Methylmalonate-semialdehyde dehydrogenase; Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively.
      
 0.489
iolR
Transcriptional regulator (DeoR family); Iol operon repressor.
      
 0.487
rapI
Response regulator aspartate phosphatase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type r: regulator; Belongs to the RAP family.
      
 0.480
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
Server load: low (40%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.